Detalhe da pesquisa
1.
Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors.
Bioorg Med Chem Lett
; 23(23): 6228-33, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24157366
2.
The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors.
Bioorg Med Chem Lett
; 22(1): 658-65, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22079761
3.
The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species.
J Lipid Res
; 52(6): 1150-1161, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21415123
4.
Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors.
Bioorg Med Chem Lett
; 21(5): 1299-305, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21315588
5.
Potential mechanism of enhanced postprandial glucagon-like peptide-1 release following treatment with a diacylglycerol acyltransferase 1 inhibitor.
Pharmacol Res Perspect
; 3(6): e00193, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27022467
6.
Diacylglycerol acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release.
PLoS One
; 8(1): e54480, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23336002
7.
Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release--potential insight into mechanism of action.
Obesity (Silver Spring)
; 21(7): 1406-15, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23671037
8.
Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety.
ACS Med Chem Lett
; 4(8): 773-8, 2013 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900745