Detalhe da pesquisa
1.
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human.
Xenobiotica
; 54(2): 64-74, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38197324
2.
Improving the Translation of Organic Anion Transporting Polypeptide Substrates using HEK293 Cell Data in the Presence and Absence of Human Plasma via Physiologically Based Pharmacokinetic Modeling.
Drug Metab Dispos
; 49(7): 530-539, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33958385
3.
Novel antibody-antibiotic conjugate eliminates intracellular S. aureus.
Nature
; 527(7578): 323-8, 2015 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26536114
4.
Optimization of globomycin analogs as novel gram-negative antibiotics.
Bioorg Med Chem Lett
; 30(20): 127419, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32768648
5.
Investigating the Impact of Albumin on the Liver Uptake of Pitavastatin and Warfarin in Nagase Analbuminemic Rats.
Drug Metab Dispos
; 47(11): 1307-1313, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31492695
6.
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.
Bioorg Med Chem Lett
; 29(16): 2294-2301, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31307887
7.
Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse.
Xenobiotica
; 49(5): 602-610, 2019 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-29768081
8.
Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor.
Xenobiotica
; 49(9): 1063-1077, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-30257601
9.
Evaluating the Utility of Canine Mdr1 Knockout Madin-Darby Canine Kidney I Cells in Permeability Screening and Efflux Substrate Determination.
Mol Pharm
; 15(11): 5103-5113, 2018 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30222362
10.
Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma.
Drug Metab Dispos
; 44(12): 1881-1889, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27638506
11.
Use of cassette dosing approach to examine the effects of P-glycoprotein on the brain and cerebrospinal fluid concentrations in wild-type and P-glycoprotein knockout rats.
Drug Metab Dispos
; 42(4): 482-91, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24398459
12.
Differential effects of Rifampin and Ketoconazole on the blood and liver concentration of atorvastatin in wild-type and Cyp3a and Oatp1a/b knockout mice.
Drug Metab Dispos
; 42(6): 1067-73, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24671957
13.
Evaluating the in vitro inhibition of UGT1A1, OATP1B1, OATP1B3, MRP2, and BSEP in predicting drug-induced hyperbilirubinemia.
Mol Pharm
; 10(8): 3067-75, 2013 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23750830
14.
Alpha-Smooth Muscle Actin Expression and Parafoveal Blood Flow Pathways Are Altered in Preclinical Diabetic Retinopathy.
Invest Ophthalmol Vis Sci
; 63(5): 8, 2022 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35522303
15.
Effect of magnesium stearate surface coating method on the aerosol performance and permeability of micronized fluticasone propionate.
Int J Pharm
; 615: 121470, 2022 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35041913
16.
RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy.
Cancer Discov
; 12(1): 204-219, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34544753
17.
Mass balance and pharmacokinetics of [14C]telavancin following intravenous administration to healthy male volunteers.
Antimicrob Agents Chemother
; 54(8): 3365-71, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20516282
18.
Functional similarity of modified cascade impactor to deposit drug particles on cells.
Int J Pharm
; 583: 119404, 2020 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32387312
19.
The Effects of Drug Metabolizing Enzyme Inhibitors on Hepatic Efflux and Uptake Transporters.
Drug Metab Lett
; 11(2): 111-118, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29032766
20.
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR.
ACS Med Chem Lett
; 7(4): 351-6, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27096040