Detalhe da pesquisa
1.
Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors.
ACS Med Chem Lett
; 14(12): 1673-1681, 2023 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38116446
2.
Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer.
J Med Chem
; 63(13): 6679-6693, 2020 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32250617
3.
Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.
ACS Med Chem Lett
; 9(12): 1230-1234, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613331
4.
Identification of a new class of glucokinase activators through structure-based design.
J Med Chem
; 56(19): 7669-78, 2013 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24015910