Detalhe da pesquisa
1.
Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3.
J Med Chem
; 48(20): 6169-73, 2005 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16190743
2.
Cell-based assays to detect inhibitors of fungal mRNA capping enzymes and characterization of sinefungin as a cap methyltransferase inhibitor.
J Biomol Screen
; 10(4): 355-64, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15964937
3.
Molecular characterization of the murine SIGNR1 gene encoding a C-type lectin homologous to human DC-SIGN and DC-SIGNR.
Gene
; 293(1-2): 33-46, 2002 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-12137941
4.
A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.
J Med Chem
; 47(27): 6662-5, 2004 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15615513
5.
Identification of Leu276 of the S1P1 receptor and Phe263 of the S1P3 receptor in interaction with receptor specific agonists by molecular modeling, site-directed mutagenesis, and affinity studies.
Mol Pharmacol
; 71(3): 724-35, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17170199
6.
SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P1) with enhanced pharmacokinetic properties.
Bioorg Med Chem Lett
; 17(3): 828-31, 2007 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17092714
7.
2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.
Bioorg Med Chem Lett
; 16(13): 3564-8, 2006 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16621543
8.
Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor.
Bioorg Med Chem Lett
; 16(14): 3684-7, 2006 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16682185
9.
Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes.
Bioorg Med Chem Lett
; 16(14): 3679-83, 2006 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16697189
10.
Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720.
Bioorg Med Chem
; 12(18): 4803-7, 2004 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15336258
11.
The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.
Bioorg Med Chem Lett
; 14(13): 3495-9, 2004 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-15177460
12.
Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.
Bioorg Med Chem Lett
; 14(12): 3351-5, 2004 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15149705
13.
Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors.
Bioorg Med Chem Lett
; 14(19): 4861-6, 2004 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-15341940
14.
Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists.
Bioorg Med Chem Lett
; 14(13): 3501-5, 2004 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-15177461