Detalhe da pesquisa
1.
The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 23(2): 466-71, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23253441
2.
Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J Med Chem
; 65(24): 16234-16251, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36475645
3.
Protein binding-dependent decreases in hERG channel blocker potency assessed by whole-cell voltage clamp in serum.
J Cardiovasc Pharmacol
; 55(4): 368-76, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20125032
4.
Iminoheterocycles as gamma-secretase modulators.
Bioorg Med Chem Lett
; 20(18): 5380-4, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20724152
5.
Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 18(1): 215-9, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17988864
6.
Temporal evaluation of CYP mRNA in mice administered with prototypical P450 inducers: comparison with conventional protein/enzyme methods.
Drug Chem Toxicol
; 31(4): 501-13, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18850359
7.
Utility of mass spectrometry for in-vitro ADME assays.
Curr Drug Metab
; 7(5): 467-77, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16787156
8.
Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease.
ACS Med Chem Lett
; 3(11): 931-5, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900409
9.
Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo.
J Med Chem
; 55(1): 489-502, 2012 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22098494
10.
The Discovery of Pyridone and Pyridazone Heterocycles as γ-Secretase Modulators.
ACS Med Chem Lett
; 1(4): 184-7, 2010 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900193
11.
The impact of protein on Caco-2 permeability of low mass balance compounds for absorption projection and efflux substrate identification.
J Pharm Biomed Anal
; 51(5): 1069-77, 2010 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-20036089
12.
Blocking ion channel KCNN4 alleviates the symptoms of experimental autoimmune encephalomyelitis in mice.
Eur J Immunol
; 35(4): 1027-36, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15770697
13.
A computer program for automated data evaluation to support in vitro higher-throughput screening for drug metabolism and pharmacokinetics attributes.
Rapid Commun Mass Spectrom
; 18(18): 2046-52, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15378716
14.
Generic fast gradient liquid chromatography/tandem mass spectrometry techniques for the assessment of the in vitro permeability across the blood-brain barrier in drug discovery.
Rapid Commun Mass Spectrom
; 16(15): 1501-5, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12125028
15.
Higher-throughput screening for Caco-2 permeability utilizing a multiple sprayer liquid chromatography/tandem mass spectrometry system.
Rapid Commun Mass Spectrom
; 17(18): 2147-52, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12955746
16.
A fully automated nanoelectrospray tandem mass spectrometric method for analysis of Caco-2 samples.
Rapid Commun Mass Spectrom
; 17(14): 1573-8, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12845582
17.
The use of in vitro metabolic stability for rapid selection of compounds in early discovery based on their expected hepatic extraction ratios.
Pharm Res
; 19(11): 1606-10, 2002 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-12458665
18.
Assessment of temporal biochemical and gene transcription changes in rat liver cytochrome P450: utility of real-time quantitative RT-PCR.
Pharm Res
; 20(9): 1373-80, 2003 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-14567630