Detalhe da pesquisa
1.
Design and synthesis of water soluble ß-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors.
Bioorg Med Chem Lett
; 26(23): 5836-5841, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27836402
2.
Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors.
Bioorg Med Chem
; 24(21): 5534-5545, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27670099
3.
Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.
Bioorg Med Chem Lett
; 25(7): 1592-6, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25728416
4.
A-ring modification of SCH 900229 and related chromene sulfone γ-secretase inhibitors.
Bioorg Med Chem Lett
; 23(3): 850-3, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23265902
5.
The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 23(2): 466-71, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23253441
6.
Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors.
Bioorg Med Chem Lett
; 23(3): 844-9, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23265892
7.
Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
Biochemistry
; 50(22): 4973-80, 2011 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21528914
8.
Synthesis and SAR study of tricyclic sulfones as γ-secretase inhibitors: C-6 and C-8 positions.
Bioorg Med Chem Lett
; 21(11): 3447-51, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21515050
9.
Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators.
Bioorg Med Chem Lett
; 21(2): 664-9, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21195610
10.
Design, synthesis, and structure-activity relationship studies of N-arylsulfonyl morpholines as γ-secretase inhibitors.
Bioorg Med Chem Lett
; 20(22): 6606-9, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20933414
11.
Tricyclic sulfones as orally active gamma-secretase inhibitors: synthesis and structure-activity relationship studies.
Bioorg Med Chem Lett
; 20(12): 3632-5, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20493690
12.
Tetracyclic sulfones as potent gamma-secretase inhibitors: synthesis and structure-activity relationship studies.
Bioorg Med Chem Lett
; 20(12): 3645-8, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20471254
13.
Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity.
Bioorg Med Chem Lett
; 20(8): 2591-6, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20236824
14.
Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability.
Bioorg Med Chem Lett
; 19(21): 6032-7, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19800786
15.
Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 18(1): 215-9, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17988864
16.
Solution-phase parallel synthesis of carbamates as gamma-secretase inhibitors.
J Comb Chem
; 10(1): 56-62, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-17988101
17.
Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.
J Med Chem
; 49(7): 2294-310, 2006 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16570926
18.
Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice.
Eur J Pharmacol
; 535(1-3): 182-91, 2006 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-16540104
19.
Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors.
Eur J Med Chem
; 124: 36-48, 2016 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-27560281
20.
Muscarinic receptor agonists and antagonists in the treatment of Alzheimer's disease.
Curr Pharm Des
; 11(26): 3353-61, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16250841