Detalhe da pesquisa
1.
Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.
Bioorg Med Chem Lett
; 28(10): 1887-1891, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29655979
2.
Cardiovascular risk factors in those born preterm - systematic review and meta-analysis.
J Dev Orig Health Dis
; 12(4): 539-554, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33028453
3.
Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP).
Biochim Biophys Acta Gen Subj
; 1865(2): 129800, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33246032
4.
Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.
J Med Chem
; 59(1): 194-205, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26653180
5.
Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
J Med Chem
; 59(24): 10974-10993, 2016 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28002967
6.
Indole Glucocorticoid Receptor Antagonists Active in a Model of Dyslipidemia Act via a Unique Association with an Agonist Binding Site.
J Med Chem
; 58(16): 6607-18, 2015 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26218343
7.
Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.
J Med Chem
; 58(11): 4727-37, 2015 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25961169
8.
The 2.5 Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.
J Med Chem
; 56(3): 963-9, 2013 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23311358
9.
Structural context of disease-associated mutations and putative mechanism of autoinhibition revealed by X-ray crystallographic analysis of the EZH2-SET domain.
PLoS One
; 8(12): e84147, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24367637
10.
Correction to The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD(+)) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition.
J Med Chem
; 59(5): 2267, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26882000