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1.
J Child Psychol Psychiatry ; 62(4): 396-403, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-32663331

RESUMO

BACKGROUND: Although factors such as adverse family background have been widely examined, little is known about the prevalence or potential impact of developmental language disorder (DLD) on risk of recidivism in young people with history of criminal justice system contact. METHODS: A total of 145 young offenders participated. An adversity score was constructed based on information found in youth justice service records. Data collected included standardised measures of expressive and receptive language, nonverbal IQ and the inventory of callous-unemotional traits. Survival analysis was performed to examine differences in reoffending risk between young offenders with and without DLD. RESULTS: The cumulative incidence of reoffending within a year of the young person's court order was markedly raised in the DLD group (62%; 95% CI 52, 72) versus the non-DLD group (25%; 95% CI 16, 39). Furthermore, in the final multivariable survival analysis the independent elevation in risk linked with DLD was not greatly attenuated with adjustment for nonverbal IQ, adversity score, age at first offence, number of previous offences and deprivation score. DLD was the most significant predictor with an adjusted hazard ratio of 2.61 (95% CI 1.80, 3.78). CONCLUSIONS: Young offenders with DLD are more than twice as likely to reoffend than their unaffected offending peers. DLD is a powerful predictor of recidivism above and beyond other known risk factors.


Assuntos
Criminosos , Transtornos do Desenvolvimento da Linguagem , Reincidência , Adolescente , Escolaridade , Humanos , Idioma , Transtornos do Desenvolvimento da Linguagem/epidemiologia
2.
Int J Lang Commun Disord ; 56(2): 248-256, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33624420

RESUMO

BACKGROUND: A range of factors may impact whether children access speech-language pathology (SLP) services, beyond their communication difficulties. For instance, co-occurring psychosocial difficulties may amplify children's observable difficulties, leading to greater access. It is important to examine such associations because they may reflect inherent differences between children with language difficulties who access services and those who do not, indicating under-servicing for subgroups in the community. AIMS: The first aim was to examine possible differences in psychosocial difficulties between children with language difficulties who did versus did not access SLP services in the past 12 months. The second aim was to examine the unique contribution of psychosocial difficulties to service access, over and above language difficulties and other common predictors of service access. METHODS & PROCEDURES: Analyses were carried out on data gathered from 808 eleven-year-old children who took part in the Early Language in Victoria Study (ELVS). Children were categorized as having language difficulties based on their CELF-4 Core Language Score with a cut-point of > 1.25 SD below the mean. The primary outcome measure was access to SLP services in the past 12 months. Comparison and predictor variables included children's psychosocial difficulties, language skills, relevant demographic variables (gender, caregiver education) and prior SLP access. OUTCOMES & RESULTS: A total of 42 children with language difficulties who had accessed SLP services had significantly greater psychosocial difficulties than those who had not (SDQ Total Difficulties, U = 53.00, z = -4.080, p < 0.001). Using binary logistic regression, a model examining child gender, caregiver education, psychosocial difficulties (internalizing and externalizing behaviours), language difficulties and prior SLP access (in earlier years) was significant χ2 (8) = 137.285, p< 0.001, with increased externalizing difficulties (OR = 1.213, p < 0.001), increased communication difficulties (OR = 0.949, p < 0.001), and prior SLP access (OR = 7.430, p < 0.001) identified as unique predictors of service access. CONCLUSIONS & IMPLICATIONS: The results indicate that children with language difficulties who have comorbid psychosocial difficulties are more likely to access services than those who do not. Accordingly, children with language difficulties who access clinical services may require interdisciplinary support, while children without co-morbid psychosocial difficulties may be under-referred for SLP services. What this paper adds What is already known on this subject There is evidence that a range of personal and contextual factors impact the likelihood of a person accessing healthcare services beyond the specific issue of concern. What this paper adds to existing knowledge In this population-based study, we provide statistical evidence that children with language difficulties who had higher levels of psychosocial difficulties were more likely to access SLP services than those who had lower levels. What are the potential or actual clinical implications of this work? Children with language difficulties who access SLP services may require support for psychosocial difficulties, while children who do not have comorbid difficulties may be underserviced in the community.


Assuntos
Transtornos da Comunicação , Patologia da Fala e Linguagem , Criança , Comunicação , Comorbidade , Atenção à Saúde , Humanos
3.
Int J Lang Commun Disord ; 55(4): 583-602, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32497383

RESUMO

BACKGROUND: Children with developmental language disorder (DLD) are at higher risk of poorer mental health compared with children without DLD. There are, however, considerable individual differences that need to be interpreted, including the identification of protective factors. AIMS: Pathways from the early language and communication environment (ELCE, 1-2 years) to internalizing (peer and emotional problems) and externalizing (conduct problems and hyperactivity) problems in middle childhood (11 years) were mapped using structural equation modelling. Specifically, the role of indirect pathways via social skills (friendships, play and prosociality) in childhood (7-9 years) was investigated. METHODS & PROCEDURES: Secondary analysis of existing data from the Avon Longitudinal Study of Parents and Children (ALSPAC) was undertaken. The study sample consisted of 6531 children (394 with DLD). OUTCOMES & RESULTS: The pathways from the ELCE to internalizing and externalizing problems were similar for children with and without DLD. For both groups, a positive ELCE was associated with more competent social play and higher levels of prosociality in childhood, which in turn were associated with fewer externalizing problems in middle childhood. Furthermore, better friendships and higher levels of prosociality in childhood were both associated with fewer internalizing problems in middle childhood. CONCLUSIONS & IMPLICATIONS: A child's ELCE is potentially important not only for the development of language but also for social development. Furthermore, in the absence of adequate language ability, play and prosocial behaviours may allow children with DLD to deploy, practise and learn key social skills, thus protecting against externalizing problems. We suggest that consideration be given to play- and prosociality-based educational and therapeutic services for children with DLD. What this paper adds What is already known on this subject On the whole, children with DLD tend to have poorer mental health compared with their unaffected peers. There are, however, considerable differences and poor outcomes are not inevitable. What this study adds to the existing knowledge We demonstrate that children's ECLE is important for the development of social play behaviours and prosociality. Whilst children with DLD tend to have less competent social play and lower levels of prosociality compared with their unaffected peers, those with more competent social play and higher levels of prosociality are likely to have fewer externalizing problems later in childhood. We speculate that in the absence of adequate structural language ability, play and prosocial behaviours allow children with DLD to deploy, practise and learn key relationship skills, alongside behavioural and emotional regulation skills, thus protecting against externalizing problems. What are the potential or actual clinical implications of this work? Understanding the relationships among play, prosociality and externalizing problems may pave the way for play- and prosociality-based interventions in children with DLD. This may be particularly appealing for practitioners as such interventions capitalize on one of the most intuitive means of learning in childhood: play with friends. The likelihood of acceptability and engagement with such interventions may be higher in children than for traditional adult-led, paper-and-pencil activities.


Assuntos
Relações Interpessoais , Transtornos do Desenvolvimento da Linguagem/psicologia , Comportamento Social , Criança , Pré-Escolar , Feminino , Amigos , Humanos , Lactente , Controle Interno-Externo , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Estudos Longitudinais , Masculino , Jogos e Brinquedos
4.
Eur Child Adolesc Psychiatry ; 28(7): 993-1004, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30519863

RESUMO

Children and adolescents with developmental language disorder (DLD) are, overall, vulnerable to difficulties in emotional adjustment and in peer relations. However, previous research has shown that different subgroups follow different trajectories in respect to the quality of peer relations. Less is known about the trajectories of emotional development. We consider here the possibility that development in these two domains is interrelated: that is, the trajectories of emotional and peer problems will proceed in parallel. We conducted longitudinal joint trajectories analyses of emotional and peer relations in a sample of young people identified as having DLD at the age of 7 years and seen at intervals up to 16 years. Potential influences on joint trajectory group membership were examined. Findings revealed five distinct joint trajectories. Emotional and peer difficulties do occur together from childhood to adolescence for just over half of the sample, but not all. The variables most clearly associated with group membership were pragmatic language ability, prosociality and parental mental health. This is the first study to examine joint longitudinal trajectories of emotional and peer difficulties in individuals with DLD. We demonstrate that development in individuals with DLD is heterogeneous and identify three key variables associated with personal and social adjustment from childhood to adolescence. Theoretical and clinical implications of these findings are discussed.


Assuntos
Emoções/fisiologia , Relações Interpessoais , Transtornos do Desenvolvimento da Linguagem/fisiopatologia , Adolescente , Criança , Feminino , Humanos , Estudos Longitudinais , Masculino , Grupo Associado
5.
Legal Criminol Psychol ; 24(2): 195-214, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31588178

RESUMO

PURPOSE: Previous research demonstrates an association between developmental language disorder (DLD) and criminal offending. International research also implicates alexithymia as being over-represented in forensic samples. This study provides a comprehensive examination of the psycholinguistic and socioemotional profiles of males and females in the youth justice system, with a focus on first-time entrants. In the context of restorative justice (RJ) underpinning youth justice disposals, this allows for informed intervention and identifies those who may be compromised in their ability to effectively engage in certain interventions. METHODS: Participants (N = 145) from a triage centre and youth offending teams, with a mean age of 15.8, completed a range of standardized psycholinguistic assessments considering non-verbal IQ, expressive and receptive language measures, and literacy. Additionally, socioemotional measures completed included The Alexithymia Scale and the Strengths and Difficulties Questionnaire. RESULTS: Developmental language disorder was present in 87 participants. Except for the emotional score, no statistically significant gender differences were found. The mean language scores for the DLD group were more than 2.25 standard deviations below the normative mean, and they demonstrated greater literacy difficulties. A high proportion of the group met the criteria for alexithymia/possible alexithymia (60%), and this was not associated with DLD. CONCLUSIONS: High prevalence values for DLD and socioemotional difficulties, not generally gender-specific, were found. These difficulties have the possibility to compromise a young person's ability to engage in rehabilitative strategies. Language assessment and identification of difficulties, especially DLD, upon entry to the youth justice service, would assist when planning interventions.

6.
J Pediatr ; 198: 234-239.e1, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29705112

RESUMO

OBJECTIVE: To characterize the organization of speech- and language-related white matter tracts in children with developmental speech and/or language disorders. STUDY DESIGN: We collected magnetic resonance diffusion-weighted imaging data from 41 children, ages 9-11 years, with developmental speech and/or language disorders, and compared them with 45 typically developing controls with the same age range. We used probabilistic tractography of diffusion-weighted imaging to map language (3 segments of arcuate fasciculus, extreme capsule system) and speech motor (corticobulbar) tracts bilaterally. The corticospinal and callosal tracts were used as control regions. We compared the mean fractional anisotropy and diffusivity values between atypical and control groups, covarying for nonverbal IQ. We then examined differences between atypical subgroups: developmental speech disorder (DSD), developmental language disorder, and co-occurring developmental speech and language disorder. RESULTS: Fractional anisotropy in the left corticobulbar tract was lower in the DSD than in the control group. Radial and mean diffusivity were higher in the DSD than the developmental language disorder, co-occurring developmental speech and language disorder, or control groups. There were no group differences for any metrics in the language or control tracts. CONCLUSIONS: Atypical development of the left corticobulbar tract may be a neural marker for DSD. This finding is in line with reports of speech disorder after left corticobulbar damage in children and adults with brain injury. By contrast, we found no association between diffusion metrics in language-related tracts in developmental language disorder, and changes for language disorders are likely more complex.


Assuntos
Transtornos do Desenvolvimento da Linguagem/diagnóstico por imagem , Tratos Piramidais/diagnóstico por imagem , Distúrbios da Fala/diagnóstico por imagem , Substância Branca/diagnóstico por imagem , Anisotropia , Estudos de Casos e Controles , Criança , Imagem de Difusão por Ressonância Magnética , Imagem de Tensor de Difusão , Feminino , Humanos , Masculino
7.
PLoS Genet ; 11(3): e1004925, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25781923

RESUMO

Children affected by Specific Language Impairment (SLI) fail to acquire age appropriate language skills despite adequate intelligence and opportunity. SLI is highly heritable, but the understanding of underlying genetic mechanisms has proved challenging. In this study, we use molecular genetic techniques to investigate an admixed isolated founder population from the Robinson Crusoe Island (Chile), who are affected by a high incidence of SLI, increasing the power to discover contributory genetic factors. We utilize exome sequencing in selected individuals from this population to identify eight coding variants that are of putative significance. We then apply association analyses across the wider population to highlight a single rare coding variant (rs144169475, Minor Allele Frequency of 4.1% in admixed South American populations) in the NFXL1 gene that confers a nonsynonymous change (N150K) and is significantly associated with language impairment in the Robinson Crusoe population (p = 2.04 × 10-4, 8 variants tested). Subsequent sequencing of NFXL1 in 117 UK SLI cases identified four individuals with heterozygous variants predicted to be of functional consequence. We conclude that coding variants within NFXL1 confer an increased risk of SLI within a complex genetic model.


Assuntos
Apraxias/genética , Proteínas de Transporte/genética , Exoma/genética , Estudos de Associação Genética , Proteínas de Membrana/genética , Apraxias/patologia , Criança , Pré-Escolar , Feminino , Predisposição Genética para Doença , Genética Populacional , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Masculino
8.
Dev Psychobiol ; 60(7): 814-824, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-30101474

RESUMO

Developmental language disorder (DLD) and speech sound disorder (SSD) are common, and although scientific evidence for structural and functional alterations in DLD/SSD is accumulating, current neuroimaging studies provide an incongruent picture. Here, we hypothesized that children affected by DLD and SSD present with gray matter (or gray matter asymmetry) aberrations in brain areas associated with language processing compared to typically developing (TD) children. To assess this hypothesis, we enhanced MRI-based information with microscopically defined cytoarchitectonic probabilities of Broca's area (BA 45, BA 44) as well as an auditory area (TE 3.0). We detected a larger rightward gray matter asymmetry in BA 45 in children with DLD (n = 13) and with SSD (n = 18) compared to TD children (n = 18), albeit only on a trend level. Interestingly though, we observed significantly larger gray matter volumes in right BA 45 in DLD compared to SSD children (and also compared to TD children).


Assuntos
Córtex Auditivo/patologia , Área de Broca/patologia , Substância Cinzenta/patologia , Transtornos do Desenvolvimento da Linguagem/patologia , Neuroimagem/métodos , Transtorno Fonológico/patologia , Córtex Auditivo/diagnóstico por imagem , Área de Broca/diagnóstico por imagem , Criança , Feminino , Substância Cinzenta/diagnóstico por imagem , Humanos , Transtornos do Desenvolvimento da Linguagem/diagnóstico por imagem , Imageamento por Ressonância Magnética , Masculino , Transtorno Fonológico/diagnóstico por imagem
9.
Int J Lang Commun Disord ; 53(2): 256-270, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-29159847

RESUMO

BACKGROUND: There is now substantial literature demonstrating that a disproportionate number of young people who come into contact with youth justice services evidence unidentified language difficulties. These young people, therefore, have received little or no professional input in this area. Conversely, there is a dearth of research pertaining to criminality outcomes among those individuals with identified developmental language disorders (DLD) who have received such interventions. AIMS: To examine police-initiated contact and substance use outcomes of young adults with a history of identified DLD versus age-matched peers (AMP). Additionally, self-reported rule breaking behaviours and aggression are considered. We hypothesize that early identification/intervention reduces engagement with risky behaviour such as substance and alcohol use as well as offending-related behaviours. METHODS & PROCEDURES: Adversarial police-initiated contacts were examined in 84 young adults with a history of DLD and 88 AMP. Rule-breaking and aggression were evaluated using the Achenbach Adult Self-Report for ages 18-59 years. OUTCOMES & RESULTS: Adults with a history of DLD who received targeted intervention during their school years reported less contact with their local police service compared with AMPs at age 24. Comparable proportions of both groups reported current alcohol consumption, but group differences were found relating to alcohol use. No group differences in rule-breaking behaviours were found, but the DLD group was found to have a statistically significant higher raw score on the aggressive behaviour scale. CONCLUSIONS & IMPLICATIONS: There is a need for early identification of children with DLD. Early intervention aimed at ameliorating such difficulties could possibly have distal outcomes in relation to offending.


Assuntos
Crime , Transtornos do Desenvolvimento da Linguagem/epidemiologia , Adolescente , Adulto , Agressão , Feminino , Humanos , Transtornos do Desenvolvimento da Linguagem/psicologia , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Psicolinguística , Transtornos Relacionados ao Uso de Substâncias/epidemiologia , Transtornos Relacionados ao Uso de Substâncias/psicologia , Adulto Jovem
10.
Int J Lang Commun Disord ; 53(2): 237-255, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-29139196

RESUMO

BACKGROUND: Developmental language disorder (DLD) presents a considerable barrier for young adults to engage in further education and training. Early studies with young adults with DLD revealed poor educational achievement and lack of opportunities to progress in education. More recent studies have provided more positive findings. Relatively sparse data exist, however, on current cohorts and the factors that predict outcomes. AIMS: To examine educational and employment outcomes in young adulthood in a sample of people with histories of DLD compared with an age-matched peer group without DLD. We ask: How do educational pathways and early jobs compare between those with and without DLD? Are young adults with DLD receiving similar levels of income as their peers? To what extent are language and literacy abilities associated with outcomes? METHODS & PROCEDURES: Participants included 84 individuals with DLD (67% males) and 88 age-matched peers without DLD (56% males). Participants were on average 24 years of age. They completed a battery of psycholinguistic, literacy and nonverbal skills assessments. Data were also collected on educational qualifications, current educational status, extent of educational support received, employment status, history and support, as well as current income. OUTCOMES & RESULTS: Those with DLD obtained lower academic and vocational qualifications. Higher educational/vocational qualifications were associated with better language, better reading and higher performance IQ (PIQ). There were few differences between the two groups in terms of engagement with education, but the mean age at leaving education was significantly earlier in the participants with DLD. Substantially more participants with DLD reported receiving support or dispensation from their educational institution. There was no significant difference between groups in the proportion of young people currently employed, though a higher proportion of the age-matched peers was in work full time. Participants with DLD were much more likely to be in non-professional occupations. However, when examining pay in relation to types of occupation, the groups' incomes were broadly comparable. CONCLUSIONS & IMPLICATIONS: At the group level, young people with a history of DLD more commonly have less skilled employment and more rarely achieve professional roles. At the individual level there is considerable variation with smaller but not trivial proportions of young adults with a history of DLD showing good educational and employment outcomes. There are positive aspects to early adult outcomes for some young people with a history of DLD.


Assuntos
Escolaridade , Emprego , Transtornos do Desenvolvimento da Linguagem , Estudos de Coortes , Feminino , Humanos , Transtornos do Desenvolvimento da Linguagem/epidemiologia , Transtornos do Desenvolvimento da Linguagem/psicologia , Transtornos do Desenvolvimento da Linguagem/terapia , Alfabetização , Masculino , Psicolinguística , Adulto Jovem
11.
Artigo em Inglês | MEDLINE | ID: mdl-27974878

RESUMO

Language impairment (LI) is a common developmental disorder which affects many aspects of young people's functional skills and engagement with society. Little is known of early driving behaviour in those with this disability. This longitudinal study examines early driving experience in a sample of young adults with LI, compared with a sample of typically developing age-matched peers (AMPs). At age 24 years, significantly fewer participants with LI had acquired a driving licence. A crucial hurdle for those with LI appeared to be the Theory part of the (UK) test. Logistic regression analysis indicated that language ability and a measure of independence at age 17 contributed to the prediction of licence possession at age 24. There was no evidence of differences in traffic violations or accident rates between those with and without LI. There is little evidence that young people with LI are at greater risk on the roads than peers without LI, but some individuals with LI might benefit from support in the course of preparation for driving and in the driving test.

12.
Int J Lang Commun Disord ; 50(2): 226-40, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25469890

RESUMO

BACKGROUND: In general, children with specific language impairment (SLI) tend to fall behind their typically developing (TD) peers in educational attainment. Less is known about how children with SLI fare in particular areas of the curriculum and what predicts their levels of performance. AIMS: To compare the distributions of performance of children with SLI in three core school subjects (English, Mathematics and Science); to test the possibility that performance would vary across the core subjects; and to examine the extent to which language impairment predicts performance. METHODS & PROCEDURES: This study was conducted in England and reports historical data on educational attainments. Teacher assessment and test scores of 176 eleven-year-old children with SLI were examined in the three core subjects and compared with known national norms. Possible predictors of performance were measured, including language ability at ages 7 and 11, educational placement type, and performance IQ. OUTCOMES & RESULTS: Children with SLI, compared with national norms, were found to be at a disadvantage in core school subjects. Nevertheless, some children attained the levels expected of TD peers. Performance was poorest in English; relative strengths were indicated in Science and, to a lesser extent, in Mathematics. Language skills were significant predictors of performance in all three core subjects. PIQ was the strongest predictor for Mathematics. For Science, both early language skills at 7 years and PIQ made significant contributions. CONCLUSIONS & IMPLICATIONS: Language impacts on the school performance of children with SLI, but differentially across subjects. English for these children is the most challenging of the core subjects, reflecting the high levels of language demand it incurs. Science is an area of relative strength and mathematics appears to be intermediate, arguably because some tasks in these subjects can be performed with less reliance on verbal processing. Many children with SLI do have the potential to reach or exceed educational targets that are set at national levels for TD children.


Assuntos
Logro , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Transtornos do Desenvolvimento da Linguagem/terapia , Deficiências da Aprendizagem/diagnóstico , Instituições Acadêmicas , Criança , Currículo , Avaliação Educacional , Inglaterra , Feminino , Seguimentos , Humanos , Deficiências da Aprendizagem/terapia , Masculino , Valores de Referência
13.
Folia Phoniatr Logop ; 67(6): 293-9, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-27160319

RESUMO

The considerable variation observed in the profiles of children with language impairment (LI) raises challenges for the diagnosis, treatment and prevention of language difficulties, in particular since LI can present substantial issues calling for the investment of clinical, educational and public health resources. In this review paper, we examine biological, psychological and environmental factors that appear to influence the developmental course of LI. In this review paper we are interested not only in examining deficits and risk factors but also in identifying strengths of children with LI that can act as protective factors providing the child with a scaffold for more positive development and better outcomes.


Assuntos
Transtornos do Desenvolvimento da Linguagem/diagnóstico , Transtornos do Desenvolvimento da Linguagem/reabilitação , Resiliência Psicológica , Transtorno do Espectro Autista/diagnóstico , Transtorno do Espectro Autista/reabilitação , Criança , Pré-Escolar , Diagnóstico Diferencial , Humanos , Lactente , Comunicação Interdisciplinar , Colaboração Intersetorial , Transtornos do Desenvolvimento da Linguagem/etiologia , Fatores de Proteção , Fatores de Risco
14.
J Child Psychol Psychiatry ; 55(5): 516-27, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24410167

RESUMO

BACKGROUND: Peer relations is a vulnerable area of functioning in children with specific language impairment (SLI), but little is known about the developmental trajectories of individuals. METHODS: Peer problems were investigated over a 9-year period (from 7 to 16 years of age) in 171 children with a history of SLI. Discrete factor growth modelling was used to chart developmental trajectories. Multinomial logistic regression analysis was conducted to investigate factors associated with group membership. RESULTS: Four distinct developmental trajectories were identified: low-level/no problems in peer relations (22.2% of participants), childhood-limited problems (12.3%), childhood-onset persistent problems (39.2%) and adolescent-onset problems (26.3%). Risk of poor trajectories of peer relations was greater for those children with pragmatic language difficulties. Prosocial behaviour was the factor most strongly associated with trajectory group membership. Overall, the more prosocial children with better pragmatic language skills and lower levels of emotional problems had less difficulty in developing peer relations. CONCLUSIONS: Analysis of developmental trajectories enriches our understanding of social development. A sizeable minority in the present sample sustained positive relations through childhood and adolescence, and others overcame early difficulties to achieve low levels of problems by their early teens; the majority, however, showed childhood-onset persistent or adolescent-onset problems.


Assuntos
Relações Interpessoais , Transtornos da Linguagem/psicologia , Grupo Associado , Adolescente , Transtorno Autístico/complicações , Transtorno Autístico/psicologia , Criança , Feminino , Humanos , Transtornos da Linguagem/complicações , Testes de Linguagem , Estudos Longitudinais , Masculino , Comportamento Social
15.
Dev Med Child Neurol ; 56(4): 346-53, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24117048

RESUMO

AIM: Sex chromosome aneuploidies increase the risk of spoken or written language disorders but individuals with specific language impairment (SLI) or dyslexia do not routinely undergo cytogenetic analysis. We assess the frequency of sex chromosome aneuploidies in individuals with language impairment or dyslexia. METHOD: Genome-wide single nucleotide polymorphism genotyping was performed in three sample sets: a clinical cohort of individuals with speech and language deficits (87 probands: 61 males, 26 females; age range 4 to 23 years), a replication cohort of individuals with SLI, from both clinical and epidemiological samples (209 probands: 139 males, 70 females; age range 4 to 17 years), and a set of individuals with dyslexia (314 probands: 224 males, 90 females; age range 7 to 18 years). RESULTS: In the clinical language-impaired cohort, three abnormal karyotypic results were identified in probands (proband yield 3.4%). In the SLI replication cohort, six abnormalities were identified providing a consistent proband yield (2.9%). In the sample of individuals with dyslexia, two sex chromosome aneuploidies were found giving a lower proband yield of 0.6%. In total, two XYY, four XXY (Klinefelter syndrome), three XXX, one XO (Turner syndrome), and one unresolved karyotype were identified. INTERPRETATION: The frequency of sex chromosome aneuploidies within each of the three cohorts was increased over the expected population frequency (approximately 0.25%) suggesting that genetic testing may prove worthwhile for individuals with language and literacy problems and normal non-verbal IQ. Early detection of these aneuploidies can provide information and direct the appropriate management for individuals.


Assuntos
Aneuploidia , Dislexia/epidemiologia , Dislexia/genética , Transtornos do Desenvolvimento da Linguagem/epidemiologia , Transtornos do Desenvolvimento da Linguagem/genética , Cromossomos Sexuais , Adolescente , Criança , Pré-Escolar , Estudos de Coortes , Feminino , Genótipo , Humanos , Cariotipagem , Masculino , Idade Paterna , Polimorfismo de Nucleotídeo Único , Prevalência , Adulto Jovem
17.
Int J Lang Commun Disord ; 48(5): 534-53, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24033652

RESUMO

BACKGROUND: Identifying 3-4-year-olds who are most at risk of persisting language difficulties, and possibly specific language impairment (SLI), is difficult due to the natural variation of language in young children. In older children, markers for SLI have been identified that differentiate between children with and without SLI. It is not known whether these markers can be used at an earlier age to identify children most at risk of persisting language difficulties. AIMS: To identify possible risk markers of current status that distinguish children who have specific expressive language delay (SELD) from the variation observed in normally developing children at age 3;0-4;0 and 4;0-5;0. To determine the most suitable measure(s) that would predict which children with SELD at age 3;0-4;0 were likely to have persistent expressive language delay (PELD) at age 4;0-5;0. METHODS & PROCEDURES: Forty-seven children with SELD and 47 children with typical language development (TLD) were assessed on language, nonverbal IQ and marker tasks at age 3;0-4;0 (baseline). Ninety-one children were reassessed on the measures one year later (follow-up). At both time points, the marker tasks were compared with a reference standard (Expressive Communication subscale (EC) of the Preschool Language Scale-3 (PLS-3) (UK)) to determine the most useful marker for identifying children with SELD. Possible predictors were examined to determine the most suitable measure(s) that would predict which children with SELD at baseline were likely to have PELD at follow-up. OUTCOME & RESULTS: A modified version of Recalling Sentences, a subtest of the Clinical Evaluation of Language Fundamentals (CELF)-Preschool UK, was the most useful marker for identifying children with SELD at baseline and at follow-up. Thirty-five (76.1%) of the 46 children with SELD at baseline had PELD at follow-up. Performance on the Auditory Comprehension (AC) and EC subscales of the PLS-3 (UK) and on modified Recalling Sentences at age 3;0-4;0 were predictors of PELD at age 4;0-5;0. CONCLUSIONS & IMPLICATIONS: A modified Recalling Sentences task was a good risk marker for SELD at age 3;0-4;0 and SELD at age 4;0-5;0. PLS-3 AC, PLS-3 EC and modified Recalling Sentences at baseline were the best predictors of PELD. The use of modified Recalling Sentences as a predictive marker requires confirmation.


Assuntos
Linguagem Infantil , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Transtornos do Desenvolvimento da Linguagem/epidemiologia , Desenvolvimento da Linguagem , Testes de Linguagem , Pré-Escolar , Feminino , Seguimentos , Humanos , Estudos Longitudinais , Masculino , Rememoração Mental , Comunicação não Verbal , Fonética , Valor Preditivo dos Testes , Fatores de Risco , Escócia/epidemiologia , Semântica , Sensibilidade e Especificidade , Aprendizagem Verbal
18.
Am J Hum Genet ; 85(2): 264-72, 2009 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-19646677

RESUMO

Specific language impairment (SLI) is a common developmental disorder characterized by difficulties in language acquisition despite otherwise normal development and in the absence of any obvious explanatory factors. We performed a high-density screen of SLI1, a region of chromosome 16q that shows highly significant and consistent linkage to nonword repetition, a measure of phonological short-term memory that is commonly impaired in SLI. Using two independent language-impaired samples, one family-based (211 families) and another selected from a population cohort on the basis of extreme language measures (490 cases), we detected association to two genes in the SLI1 region: that encoding c-maf-inducing protein (CMIP, minP = 5.5 x 10(-7) at rs6564903) and that encoding calcium-transporting ATPase, type2C, member2 (ATP2C2, minP = 2.0 x 10(-5) at rs11860694). Regression modeling indicated that each of these loci exerts an independent effect upon nonword repetition ability. Despite the consistent findings in language-impaired samples, investigation in a large unselected cohort (n = 3612) did not detect association. We therefore propose that variants in CMIP and ATP2C2 act to modulate phonological short-term memory primarily in the context of language impairment. As such, this investigation supports the hypothesis that some causes of language impairment are distinct from factors that influence normal language variation. This work therefore implicates CMIP and ATP2C2 in the etiology of SLI and provides molecular evidence for the importance of phonological short-term memory in language acquisition.


Assuntos
ATPases Transportadoras de Cálcio/genética , Proteínas de Transporte/genética , Transtornos da Linguagem/genética , Memória de Curto Prazo , Proteínas Proto-Oncogênicas c-maf/genética , Proteínas Adaptadoras de Transdução de Sinal , Cromossomos Humanos Par 16 , Estudos de Coortes , Ligação Genética , Testes Genéticos , Humanos , Idioma , Transtornos da Linguagem/diagnóstico , Fonética
19.
Neuropsychol Rev ; 22(4): 384-401, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22707315

RESUMO

Most young children make significant progress in learning language during the first 4 years of life. Delays or differences in patterns of language acquisition are sensitive indicators of developmental problems. The dynamic, complex nature of language and the variability in the timing of its acquisition poses a number of challenges for the assessment of young children. This paper summarises the key developmental milestones of language development in the preschool years, providing a backdrop for understanding difficulties with language learning. Children with specific language impairment (SLI) are characterised illustrating the types of language difficulties they exhibit. Genetic evidence for language impairment suggests complex interactions among multiple genes of small effect. There are few consistent neurobiological abnormalities and currently there is no identified neurobiological signature for language difficulties. The assessment of young children's language skills thus focuses on the evaluation of their performances in comparison to typically developing peers. Assessment of language abilities in preschool children should involve an evaluation of both expressive and receptive skills and should include an evaluation of more than one dimension of language. The use of a single measure of a language component, such as vocabulary, is considered inadequate for determining whether preschool children have typical language or language impairment. Available evidence supports the inclusion of measures of phonological short-term memory in the assessment of the language abilities of preschool children. Further study of genetic, neurobiological and early behavioural correlates of language impairments in preschool children is needed.


Assuntos
Transtornos do Desenvolvimento da Linguagem/diagnóstico , Desenvolvimento da Linguagem , Testes de Linguagem , Criança , Pré-Escolar , Feminino , Humanos , Transtornos do Desenvolvimento da Linguagem/psicologia , Masculino , Memória de Curto Prazo/fisiologia , Psicometria
20.
Int J Lang Commun Disord ; 47(2): 217-28, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22369062

RESUMO

BACKGROUND: Contemporary adolescents use e-mail for a variety of purposes, including peer communication and education. Research into these uses has focused on typically developing individuals; much less is known about the use of e-mail by exceptional youth. AIMS: The present study examined the structure and form of e-mail messages sent by adolescents with and without a history of specific language impairment (SLI). METHODS & PROCEDURES: Thirty-eight adolescents with a history of SLI and 56 typically developing (TD) peers were assessed on measures of nonverbal abilities, core language skills and literacy skills (reading and spelling). The participants were asked to compose an e-mail reply to a standard e-mail sent by an experimenter. These reply e-mails were coded for linguistic structure, readability and spelling errors. Two adult raters, blind to the participants' language ability, judged how understandable the e-mails were, how grammatically correct the e-mails were, and also the sender's command of the English language. OUTCOMES & RESULTS: Adolescents with a history of SLI produced e-mails that were similar to those sent by their TD peers in terms of structure and readability. However, they made significantly more spelling errors. Furthermore, the adult raters considered the messages from participants with a history of SLI to be of poorer standard than those sent by their TD peers. CONCLUSIONS & IMPLICATIONS: The findings suggest that the e-mail messages of adolescents with a history of SLI provide indicators of the sender's language and literacy skills. Implications for intervention and technology development are discussed.


Assuntos
Correio Eletrônico , Transtornos da Linguagem , Redação , Adolescente , Estudos de Casos e Controles , Compreensão , Inglaterra , Feminino , Humanos , Masculino , Psicolinguística , Método Simples-Cego
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