Fluid modernities: the birthing pool in late twentieth-century Britain.

Birthing pools are a common feature of maternity units across Europe and North America, and in home birth practice. Despite their prevalence and popularity, these blue or white, often bulky plastic objects have received minimal empirical or theoretical analysis. This article attends to the emergence, design and meaning of such birthing pools, with a focus on the UK in the 1980s and 1990s. Across spheres of media, political and everyday debate, the pools characterise the paradoxes of 'modern maternity': they are 'fluidly' timeless and new, natural and medical, homely and unusual, safe and risky. Beyond exploring the contradictions of 'modern maternity', we also make two key interventions. First, we contend that modern maternity has substantially expanded in recent decades to hold and include additional ideas about comfort and experience. Second, we flag the culturally specific notions of 'modernity' at play in modern births: the popularity of the birthing pool was typically among white, middle-class women. We argue that birthing pools have had an impact at a critical moment in birthing people's care, and we map out the uneven and unjust terrains through which they have assumed cultural and medical prominence.

Two cases of imported respiratory diphtheria in Edinburgh, Scotland, October 2019.

We report two cases of respiratory toxigenic Corynebacterium diphtheriae infection in fully vaccinated UK born adults following travel to Tunisia in October 2019. Both patients were successfully treated with antibiotics and neither received diphtheria antitoxin. Contact tracing was performed following a risk assessment but no additional cases were identified. This report highlights the importance of maintaining a high index of suspicion for re-emerging infections in patients with a history of travel to high-risk areas outside Europe.

Sources and Resources'The NHS Should not be Condemned to the History Books': Public Engagement as a Method in Social Histories of Medicine.

This article explores the public engagement work of the Cultural History of the National Health Service (NHS) project, conducted at the University of Warwick between 2016 and 2019 and aiming to explore the meanings attached to Britain's NHS over its 70-year history. The article situates public engagement as a critical methodology for social historians of medicine, exploring how events deepened this project's understandings of post-war welfare, childhood treatments and activist cultures. Through reflection on these themes, the article emphasises that public engagement can generate rich new forms of qualitative testimony, complementing archival documents; point us towards 'hidden archives'; and challenge cultural visions of historical research as 'condemning' or 'celebrating' its subjects. Finally, the article provides critical reflection on the challenges of such work and argues that engagement around health makes visible the broader research challenges of emotional intensity, personal and professional boundaries, and the hierarchies ingrained in academic research.

'Save our NHS': activism, information-based expertise and the 'new times' of the 1980s.

This article examines activism in defence of the National Health Service (NHS), which emerges in the 1960s to defend local hospitals from closure. From the mid-1980s, a new form of campaigning developed, which sought to protect the Service nationally. Tracing this campaigning illuminates, first, that small groups played a significant role in negotiating political change, and in contributing to cultural change which, in turn, has become politically powerful. Second, this demonstrates that the 1980s were 'new times' in welfare politics, as Thatcher's changes fostered voluntary interest in information-led expertise, and a new vision of the NHS as a significant, much valued, national institution.

Why the history of public consultation matters for contemporary health policy.

Contemporary policy debates construct public involvement in England's National Health Service as "new," or as a practice dating back only as far as the 1990s. This article argues that the longer historical contexts of such consultative practice matter, and it explores various and shifting manifestations of "consultation" in the NHS from the foundation of the Service in 1948. In doing so, it first demonstrates that consultation has always been a part of the theory and practice of postwar health policy. Thinking about consultation as "new" presents such practice as unnecessary or transient, and may function as part of a damaging political vision of public affection for the NHS as a barrier to reform. Second, the article asserts that public interest in shaping NHS practice and policy has never been fully satisfied by official consultative mechanisms. "The public" is not a homogeneous group, but rather composed of various groups, communities, and individuals with rich perspectives and histories to share, having experienced the NHS as patients, friends, supporters, staff, and volunteers. Policy-makers should approach diverse publics as partners, and should meaningfully listen to protests around NHS reform, which often reflect public investment in the NHS, as well as valid concerns about how particular communities will be able to access health care. While the political will for such engagement has varied over time, individual politicians and local-level health agencies can make a difference by supporting, engaging with, and funding organizations which represent and empower a diverse range of communities: such groups have always, and will continue to play, a significant role in shaping NHS debate and care.

Sub-chronic antipsychotic drug treatment does not alter brain phospholipid fatty acid composition in rats.

Altered membrane phospholipid fatty acid composition is reported in schizophrenia and appears to be reduced by antipsychotic drug treatment. To determine whether antipsychotic drugs have a direct effect on brain phospholipid fatty acid composition, the effects of sub-chronic treatment with a "typical" and an "atypical" antipsychotic drug were determined in adult male Sprague-Dawley rats. Rats were treated with haloperidol (1 mg/kg), clozapine (20 mg/kg) or vehicle daily for 21 days. Whole brain total phospholipid composition was determined by gas chromatography. No alterations in brain phospholipid composition were produced by either drug. This suggests that the apparent normalization of membrane phospholipids observed in drug-treated schizophrenic patients is not due to a direct pharmacological effect of these drugs nor can the pharmacological effects of these drugs occurring in this time frame be attributed to alterations in neuronal membrane fatty acid composition.

Painful Times: The Emergence and Campaigning of Parents Against Injustice in 1980s Britain.

In July 1985 Steve and Susan Amphlett established Parents Against Injustice (PAIN) to support and represent parents falsely accused of child abuse. The Amphletts ran the organization from their own home, and struggled to gain funding, before closing PAIN in 1999. PAIN was to an extent a reflection of the 'new politics' of identity and lifestyle, concurrent with the rise of New Social Movements, as falsely accused parents utilized communication technologies to make their experiences public, and to contact and support one another. At the same time, PAIN also sought to exert political influence through relatively traditional channels--contributing to public inquiries, encouraging their membership to write letters to Members of Parliament, and shaping media critique. Despite its small size, PAIN was able to act as an intermediary between parents and politicians, social workers, solicitors and physicians. PAIN represented, but also collated and shaped, parents' experiences. The case study of PAIN suggests that small groups have been able to mediate between 'public' and 'experts', effectively working with both groups because of their ability to combine experience and professionalism. These groups have brought experiential knowledge into social policy, and more broadly shifted the roles and responsibilities accorded to children, families and parents.

'The bones tell a story the child is too young or too frightened to tell': The Battered Child Syndrome in Post-war Britain and America.

This article traces the emergence of child abuse as a medical concern in post-war Britain and America. In the early 1960s American paediatricians and radiologists defined the 'battered child syndrome' to characterise infants subjected to serious physical abuse. In the British context, paediatricians and radiologists, but also dermatologists and ophthalmologists, drew upon this work and sought to identify clear diagnostic signs of child maltreatment. For a time, the x-ray seemed to provide a reliable and objective visualisation of child maltreatment. By 1970, however, medical professionals began to invite social workers and policy makers to aid them in the diagnosis and management of child abuse. Discourse around the 'battered child syndrome', specifically, faded away, whilst concerns around child abuse grew. The battered child syndrome was a brief phenomenon of the 1960s, examination of which can inform the histories of medical authority, radiology and secrecy and privacy in the post-war period.

Hydration of Cuphea seeds containing crystallised triacylglycerols.

Seeds that exhibit intermediate storage behaviour seem to die under conventional -18°C storage conditions. Cuphea wrightii A. Gray, C. laminuligera Koehne, C. carthagenensis (Jacq.) J.F. Macbr. and C. aequipetala Cav are considered sensitive to low temperature storage. The seeds of these species have triacylglycerols (TAG) that are crystalline at -18°C and melt when the seeds are warmed to >35°C. In contrast, seeds of tolerant species, C. lanceolata W.T. Aiton and C. hookeriana Walp., have TAG that crystallise at temperatures below -18°C and are fluid at 22°C. Cuphea seeds imbided while TAG are crystalline fail to germinate and exhibit visual damage. However, germination proceeded normally when dry seeds were warmed adequately to melt any crystalline TAG before imbibition. Reduced germination and cellular disruption including loss of lipid body compartmentation and fragmented protein bodies develop in seeds with crystalline TAG equilibrated to >0.1 g H2O g-1 DW. This damage cannot be reversed, even when seeds are dried before the damage can be visually detected. Results from this work reveal that the seeds of some species with intermediate type physiologies can be successfully placed into conventional -18 and -80°C storage facilities.

Neural crest stem and progenitor cells.

Neural crest cells are a multipotent, migratory cell population that generates an astonishingly diverse array of cell types during vertebrate development. These include bones; tendons; neurons; glia; melanocytes; and connective, endocrine, and adipose tissue. With a limited capacity for self-renewal and a wide range of differentiation fates, neural crest cells bear many of the hallmarks of stem cells and persist throughout embryonic and adult development. But are all neural crest cells true stem cells, or do the majority of neural crest cells more closely resemble progenitor cells? In this review we discuss recent advances in characterizing the properties of neural crest cells, together with their potential for tissue-specific repair.

Triacylglycerol phase and 'intermediate' seed storage physiology: a study of Cuphea carthagenensis.

Seeds with 'intermediate' storage physiology store poorly under cold and dry conditions. We tested whether the poor shelf life can be attributed to triacylglycerol phase changes using Cuphea carthagenensis (Jacq.) seeds. Viability remained high when seeds were stored at 25 degrees C, but was lost quickly when seeds were stored at 5 degrees C. Deterioration was fastest in seeds with high (>or=0.10 g g(-1)) and low (0.01 g g(-1)) water contents (g H(2)O g dry mass(-1)), and slowest in seeds containing 0.04 g g(-1). A 45 degrees C treatment before imbibition restored germination of dry seeds by melting crystallized triacylglycerols. Here, we show that the rate of deterioration in C. carthagenensis seeds stored at 5 degrees C correlated with the rate that triacylglycerols crystallized within the seeds. Lipid crystallization, measured using differential scanning calorimetry, occurred at 6 degrees C for this species and was fastest for seeds stored at 5 degrees C that had high and very low water contents, and slowest for seeds containing 0.04 g g(-1). Germination decreased to 50% (P50) when between 16 and 38% of the triacylglycerols crystallized; complete crystallization took from 10 to over 200 days depending on water content. Our results demonstrate interactions between water and triacylglycerols in seeds: (1) water content affects the propensity of triacylglycerols to crystallize and (2) hydration of seed containing crystallized triacylglycerols is lethal. We suggest that these interactions form the basis of the syndrome of damage experienced when seeds with intermediate storage physiologies are placed in long-term storage.

Massive cellular disruption occurs during early imbibition of Cuphea seeds containing crystallized triacylglycerols.

The transition from anhydrobiotic to hydrated state occurs during early imbibition of seeds and is lethal if lipid reserves in seeds are crystalline. Low temperatures crystallize lipids during seed storage. We examine the nature of cellular damage observed in seeds of Cuphea wrightii and C. lanceolata that differ in triacylglycerol composition and phase behavior. Intracellular structure, observed using transmission electron microscopy, is profoundly and irreversibly perturbed if seeds with crystalline triacylglycerols are imbibed briefly. A brief heat treatment that melts triacylglycerols before imbibition prevents the loss of cell integrity; however, residual effects of cold treatments in C. wrightii cells are reflected by the apparent coalescence of protein and oil bodies. The timing and temperature dependence of cellular changes suggest that damage arises via a physical mechanism, perhaps as a result of shifts in hydrophobic and hydrophilic interactions when triacylglycerols undergo phase changes. Stabilizers of oil body structure such as oleosins that rely on a balance of physical forces may become ineffective when triacylglycerols crystallize. Recent observations linking poor oil body stability and poor seed storage behavior are potentially explained by the phase behavior of the storage lipids. These findings directly impact the feasibility of preserving genetic resources from some tropical and subtropical species.

Tcof1/Treacle is required for neural crest cell formation and proliferation deficiencies that cause craniofacial abnormalities.

Neural crest cells are a migratory cell population that give rise to the majority of the cartilage, bone, connective tissue, and sensory ganglia in the head. Abnormalities in the formation, proliferation, migration, and differentiation phases of the neural crest cell life cycle can lead to craniofacial malformations, which constitute one-third of all congenital birth defects. Treacher Collins syndrome (TCS) is characterized by hypoplasia of the facial bones, cleft palate, and middle and external ear defects. Although TCS results from autosomal dominant mutations of the gene TCOF1, the mechanistic origins of the abnormalities observed in this condition are unknown, and the function of Treacle, the protein encoded by TCOF1, remains poorly understood. To investigate the developmental basis of TCS we generated a mouse model through germ-line mutation of Tcof1. Haploinsufficiency of Tcof1 leads to a deficiency in migrating neural crest cells, which results in severe craniofacial malformations. We demonstrate that Tcof1/Treacle is required cell-autonomously for the formation and proliferation of neural crest cells. Tcof1/Treacle regulates proliferation by controlling the production of mature ribosomes. Therefore, Tcof1/Treacle is a unique spatiotemporal regulator of ribosome biogenesis, a deficiency that disrupts neural crest cell formation and proliferation, causing the hypoplasia characteristic of TCS craniofacial anomalies.

Triacylglycerols determine the unusual storage physiology of Cuphea seed.

Many species within the genus Cuphea (Lythraceae) produce seed with high levels of medium-chain fatty acids. Seeds of some Cuphea species lose viability when placed into storage at -18 degrees C. These species tolerate significant drying to 0.05 g/g and may, therefore, be intermediate in their storage characteristics. The thermal properties of seed lipids were observed using differential scanning calorimetry. Species with peak lipid melting temperatures >/=27 degrees C were found to be sensitive to -18 degrees C exposure while those with melting temperatures <27 degrees C were able to tolerate low-temperature exposure. This relationship was determined by the triacylglycerol composition of the individual species. Sensitive species have high concentrations of lauric acid (C(12)) and/or myristic acid (C(14)). Species with high concentrations of capric (C(8)) or caprylic acid (C(10)) or with high concentrations of unsaturated fatty acids tolerate low temperature exposure. Potential damage caused by low temperature exposure can be avoided by exposing seeds to a brief heat pulse of 45 degrees C to melt solidified lipids prior to imbibition. The relationship between the behavior of triacylglycerols in vivo, seed storage behavior and sensitivity to imbibitional damage is previously unreported and may apply to other species with physiologies that make them difficult to store.