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1.
BMC Public Health ; 11 Suppl 2: S6, 2011 Mar 04.
Artigo em Inglês | MEDLINE | ID: mdl-21388566

RESUMO

The Armed Forces Health Surveillance Center's Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) supports and oversees surveillance for emerging infectious diseases, including respiratory diseases, of importance to the U.S. Department of Defense (DoD). AFHSC-GEIS accomplishes this mission by providing funding and oversight to a global network of partners for respiratory disease surveillance. This report details the system's surveillance activities during 2009, with a focus on efforts in responding to the novel H1N1 Influenza A (A/H1N1) pandemic and contributions to global public health. Active surveillance networks established by AFHSC-GEIS partners resulted in the initial detection of novel A/H1N1 influenza in the U.S. and several other countries, and viruses isolated from these activities were used as seed strains for the 2009 pandemic influenza vaccine. Partners also provided diagnostic laboratory training and capacity building to host nations to assist with the novel A/H1N1 pandemic global response, adapted a Food and Drug Administration-approved assay for use on a ruggedized polymerase chain reaction platform for diagnosing novel A/H1N1 in remote settings, and provided estimates of seasonal vaccine effectiveness against novel A/H1N1 illness. Regular reporting of the system's worldwide surveillance findings to the global public health community enabled leaders to make informed decisions on disease mitigation measures and controls for the 2009 A/H1N1 influenza pandemic. AFHSC-GEIS's support of a global network contributes to DoD's force health protection, while supporting global public health.


Assuntos
Saúde Global , Vírus da Influenza A Subtipo H1N1 , Influenza Humana/epidemiologia , Doenças Respiratórias/epidemiologia , Vigilância de Evento Sentinela , Humanos , Influenza Humana/prevenção & controle , Medicina Militar , Pandemias , Doenças Respiratórias/prevenção & controle , Estados Unidos/epidemiologia , United States Department of Defense
2.
Am J Trop Med Hyg ; 97(5): 1477-1481, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28820695

RESUMO

Recent biosurveillance findings at Joint Base San Antonio (JBSA), a large military installation located in south-central Texas, indicate the potential for vector-borne human Chagas disease. A cross-sectional study was conducted to determine the prevalence and seroprevalence of Trypanosoma cruzi infection in highest risk subpopulations on the installation, including students and instructors who work and sleep in triatomine-endemic field settings. Real-time polymerase chain reaction, enzyme-linked immunosorbent assay, and indirect immunofluorescent antibody assay were performed on enrolled subjects (N = 1,033), none of whom tested positive for T. cruzi or anti-T. cruzi antibodies. Current countermeasures used during field training on JBSA appear to be sufficient for preventing autochthonous human Chagas disease.


Assuntos
Doença de Chagas/epidemiologia , Doença de Chagas/transmissão , Militares , Adolescente , Adulto , Animais , Anticorpos Antiprotozoários/sangue , Estudos Transversais , Feminino , Humanos , Insetos Vetores/parasitologia , Masculino , Prevalência , Fatores de Risco , Estudos Soroepidemiológicos , Texas/epidemiologia , Triatoma/parasitologia , Trypanosoma cruzi/isolamento & purificação , Adulto Jovem
3.
Virology ; 375(2): 550-60, 2008 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-18343476

RESUMO

Walleye dermal sarcoma virus is a complex retrovirus that is associated with walleye dermal sarcomas that are seasonal in nature. Fall developing tumors contain low levels of spliced accessory gene transcripts A and B, suggesting a role for the encoded proteins, Orf A and Orf B, in oncogenesis. In explanted tumor cells the 35 kDa Orf B accessory protein is localized to the cell periphery in structures similar to focal adhesions and along actin stress fibers. Similar localization was observed in mammalian cells. The cellular protein, receptor for activated C kinase 1 (RACK1), bound Orf B in yeast two-hybrid assays and in cell culture. Sequence analysis of walleye RACK1 demonstrated high conservation to other known RACK1 sequences. RACK1 binds to activated protein kinase C (PKC). Orf B associates with PKCalpha, which is constitutively activated and localized at the membrane. Activated PKC promoted cell survival, proliferation, and increased cell viability in Orf B-expressing cells.


Assuntos
Epsilonretrovirus/química , Proteínas de Ligação ao GTP/metabolismo , Proteínas de Neoplasias/metabolismo , Proteína Quinase C/metabolismo , Receptores de Superfície Celular/metabolismo , Infecções por Retroviridae/virologia , Infecções Tumorais por Vírus/virologia , Proteínas Virais/metabolismo , Sequência de Aminoácidos , Animais , Divisão Celular/fisiologia , Linhagem Celular , Ativação Enzimática , Epsilonretrovirus/patogenicidade , Proteínas de Ligação ao GTP/genética , Humanos , Dados de Sequência Molecular , Proteínas de Neoplasias/genética , Ligação Proteica , Receptores de Quinase C Ativada , Receptores de Superfície Celular/genética , Alinhamento de Sequência , Transdução de Sinais , Regulação para Cima
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