Detalhe da pesquisa
1.
Relacorilant, a Selective Glucocorticoid Receptor Modulator in Development for the Treatment of Patients With Cushing Syndrome, Does Not Cause Prolongation of the Cardiac QT Interval.
Endocr Pract
; 30(1): 11-18, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37805100
2.
Omecamtiv mecarbil does not prolong QTc intervals at therapeutic concentrations.
Br J Clin Pharmacol
; 88(1): 187-198, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34131942
3.
E2027 Cardiac Safety Evaluation With Concentration-Response Modeling of ECG Data to Inform Dose Selection in Studies in Patients With Dementia With Lewy Bodies.
Alzheimer Dis Assoc Disord
; 36(3): 208-214, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35622456
4.
Intravenous Amisulpride Does Not Meaningfully Prolong the QTc Interval at Doses Effective for the Management of Postoperative Nausea and Vomiting.
Anesth Analg
; 132(1): 150-159, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31913911
5.
Diurnal QT analysis in patients with sotalol after cardioversion of atrial fibrillation.
Ann Noninvasive Electrocardiol
; 26(4): e12834, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33629473
6.
Comparison of electrocardiograms (ECG) waveforms and centralized ECG measurements between a simple 6-lead mobile ECG device and a standard 12-lead ECG.
Ann Noninvasive Electrocardiol
; 26(6): e12872, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34288227
7.
Detection and impact of hysteresis when evaluating a drug's QTc effect using concentration-QTc analysis.
J Pharmacokinet Pharmacodyn
; 48(2): 187-202, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33118135
8.
Potential strategy for assessing QT/QTc interval for drugs that produce rapid changes in heart rate: Electrocardiographic assessment of the effects of intravenous remimazolam on cardiac repolarization.
Br J Clin Pharmacol
; 86(8): 1600-1609, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32144789
9.
Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study of the Effects of Omadacycline on QT/QTc Intervals in Healthy Subjects.
Antimicrob Agents Chemother
; 63(10)2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31405867
10.
Cardiac risk assessment based on early Phase I data and PK-QTc analysis is concordant with the outcome of thorough QTc trials: an assessment based on eleven drug candidates.
J Pharmacokinet Pharmacodyn
; 46(6): 617-626, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31667657
11.
Effects of intranasal kinetic oscillation stimulation on heart rate variability.
Ann Noninvasive Electrocardiol
; 23(1)2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-28590043
12.
A Phase I, Randomized, Double-Blinded, Placebo- and Moxifloxacin-Controlled, Four-Period Crossover Study To Evaluate the Effect of Gepotidacin on Cardiac Conduction as Assessed by 12-Lead Electrocardiogram in Healthy Volunteers.
Antimicrob Agents Chemother
; 61(5)2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28223381
13.
Solithromycin, a novel macrolide, does not prolong cardiac repolarization: a randomized, three-way crossover study in healthy subjects.
J Antimicrob Chemother
; 72(2): 515-521, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27798210
14.
Comparing QT interval variability of semiautomated and high-precision ECG methodologies in seven thorough QT studies-implications for the power of studies intended for definitive evaluation of a drug's QT effect.
Ann Noninvasive Electrocardiol
; 22(1)2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27995684
15.
Considerations for assessing the potential effects of antidiabetes drugs on cardiac ventricular repolarization: A report from the Cardiac Safety Research Consortium.
Am Heart J
; 170(1): 23-35, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26093861
16.
Evaluation of the QT effect of a combination of piperaquine and a novel anti-malarial drug candidate OZ439, for the treatment of uncomplicated malaria.
Br J Clin Pharmacol
; 80(4): 706-15, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25966781
17.
Safety, pharmacokinetics, pharmacogenomics and QT concentration-effect modelling of the SirT1 inhibitor selisistat in healthy volunteers.
Br J Clin Pharmacol
; 79(3): 477-91, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25223836
18.
An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease.
Br J Clin Pharmacol
; 79(3): 465-76, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25223731
19.
Detection of QTc effects in small studies--implications for replacing the thorough QT study.
Ann Noninvasive Electrocardiol
; 20(4): 368-77, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25367715
20.
Clinical ECG Assessment.
Handb Exp Pharmacol
; 229: 435-68, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26091650