Expression pattern of PCAT1, PCAT2, and PCAT5 lncRNAs and their value as diagnostic biomarkers in patients with gastric cancer.

BACKGROUND: Gastric cancer (GC), is a complex multifactorial neoplasm with a high mortality and prevalence rate all over the world. Hence, it is necessary to identify the multiple pathways that are previously unknown and are involved in its initiation and progression. Recently, it has become clear that long non-coding RNAs (lncRNAs) play a crucial role in the onset and spread of cancer. The current study assessed the lncRNAs PCAT1, PCAT2, and PCAT5 expression in primary gastric tumors and adjacent noncancerous tissues. METHODS: 90 pairs of GC and adjacent noncancerous tissue samples were obtained. Total RNA was extracted, then cDNA was synthesized. Using quantitative reverse transcriptase PCR (qRT-PCR), PCAT1, PCAT2, and PCAT5 expression levels were evaluated. Using the SPSS statistical package, the correlation between clinicopathological characteristics and the expression of PCAT1, PCAT2, and PCAT5 was investigated. The diagnostic value of PCAT1, PCAT2, and PCAT5 in GC was assessed using the receiver operating characteristic (ROC) curve analysis. RESULTS: Compared to surrounding non-cancerous tissues, PCAT1, PCAT2, and PCAT5 were all significantly overexpressed in tumoral tissues (P = 0.001, P = 0.019, and P = 0.0001, respectively). PCAT5 expression was significantly associated with gender (P = 0.020), according to our research. The ROC curve's findings indicated that PCAT1, PCAT2, and PCAT5 may each function as poor diagnostic biomarkers, with respective AUC values of 64 %, 60 %, and 68 %, specificity values of 68 %, 60 %, and 76 %, and sensitivity values of 55 %, 72 %, and 52 %. CONCLUSION: Our research suggested that PCAT1, PCAT2, and PCAT5 may be engaged in promoting and developing GC cells as a novel oncogene because of the increased expression of PCAT1, PCAT2 and PCAT5 in tumor tissues of GC patients. Additionally, PCAT1, PCAT2, and PCAT5 can be thought of as poor diagnostic biomarkers for GC case detection.

Fundamental Trade-Offs Between Power and Data Transfer in Inductive Links for Biomedical Implants.

This paper studies the fundamental trade-offs between power transfer efficiency (PTE) and spectral efficiency that occur during simultaneous power and data transfer through near-field inductive links. A mathematical analysis is used to establish the relationship between PTE and channel capacity as a function of link parameters such as coupling coefficient ( k), load resistance, and surrounding environment. The analysis predicts that the optimum trade-off between power and data transfer is particularly dependent on k, which is a monotonically-decreasing function of axial distance ( d) between the coils. Real-time adaptation of the link parameters (such as load resistance and modulation type) is proposed to automatically optimize the power-data trade-off over a wide range of distances and coupling coefficients. A bench-top prototype of such an adaptive link is demonstrated at a center frequency of 13.56 MHz. The prototype uses an ultrasound transducer to measure d with accuracy  mm, and uses this information to autonomously optimize both data rate (up to  âˆ¼ 50 Mbps) and PTE (up to  âˆ¼ 25%) as the coil-coil distance varies within the 4-15 mm range.

Flexible Body-Conformal Ultrasound Patches for Image-Guided Neuromodulation.

The paper presents the design and validation of body-conformal active ultrasound patches with integrated imaging and modulation modalities for image-guided neural therapy. A mechanically-flexible linear 64-element array of piezoelectric transducers with a resonance frequency of 5 MHz was designed for nerve localization. A second 8-element array using larger elements was integrated on the wearable probe for low intensity focused ultrasound neuromodulation at a resonance frequency of 1.3 MHz. Full-wave simulations were used to model the flexible arrays and estimate their generated pressure profiles. A focal depth of 10-20 mm was assumed for beamforming and focusing to support modulation of the vagus, tibial, and other nerves. A strain sensor integrated on the probe provides patient-specific feedback information on array curvature for real-time optimization of focusing and image processing. Each patch also includes high voltage (HV) multiplexers, transmit/receive switches, and pre-amplifiers that simplify connectivity and also improve the signal-to-noise ratio (SNR) of the received echo signals by  âˆ¼ 5 dB. Experimental results from a flexible prototype show a sensitivity of 80 kPa/V with  âˆ¼ 3 MHz bandwidth for the modulation and 20 kPa/V with  âˆ¼ 6 MHz bandwidth for the imaging array. An algorithm for accurate and automatic localization of targeted nerves based on using nearby blood vessels (e.g., the carotid artery) as image markers is also presented.