1.
Bioorg Med Chem Lett
; 25(2): 207-9, 2015 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25499437
RESUMO
A structure-activity relationship study on polyamine derivatives led to the synthesis and the determination of antikinetoplastid activity of 17 compounds. Among them, a spermidine derivative (compound 13) was specifically active in vitro against Leishmania donovani axenic amastigotes (IC50 at 5.4µM; Selectivity Index >18.5) and a spermine derivative (compound 28) specifically active against Trypanosoma brucei gambiense (IC50 at 1.9µM; Selectivity Index >52).