Detalhe da pesquisa
1.
Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.
Bioorg Med Chem Lett
; 27(11): 2559-2566, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28431879
2.
Structure Guided Discovery of Novel Pan Metallo-ß-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
J Med Chem
; 67(5): 3400-3418, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38387069
3.
Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J Med Chem
; 65(24): 16234-16251, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36475645
4.
(+)-Sorangicin A: evolution of a viable synthetic strategy.
Tetrahedron
; 67(51): 9809-9828, 2011 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22247573
5.
Transfer learning for bearing performance degradation assessment based on deep hierarchical features.
ISA Trans
; 108: 343-355, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-32977933
6.
Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic.
J Med Chem
; 64(11): 7691-7701, 2021 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34038119
7.
Total synthesis of (+)-sorangicin A.
J Am Chem Soc
; 131(34): 12109-11, 2009 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-19663510
8.
(+)-Rimocidin synthetic studies: construction of the C(1-27) aglycone skeleton.
J Org Chem
; 74(16): 5987-6001, 2009 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-19621880
9.
Hyperbaric-Oxygen Therapy Improves Survival and Functional Outcome of Acute Severe Intracerebral Hemorrhage.
Arch Med Res
; 48(7): 638-652, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29548729
10.
Alkali metal counterion control of enolate protonation stereoselectivity.
Org Lett
; 8(13): 2735-7, 2006 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-16774244
11.
In pursuit of pestalotiopsin a via zirconocene-mediated ring contraction.
Org Lett
; 8(11): 2429-31, 2006 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-16706543
12.
An efficient, second-generation synthesis of the signature dioxabicyclo[3.2.1]octane core of (+)-sorangicin A and elaboration of the (Z,Z,E)-triene acid system.
Org Lett
; 11(5): 1099-102, 2009 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-19182995
13.
A case study from the chemistry core of the Pittsburgh Molecular Library Screening Center: the Polo-like kinase polo-box domain (Plk1-PBD).
Curr Top Med Chem
; 9(13): 1194-205, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19807663
14.
Pestalotiopsin a. Enantioselective construction of potential building blocks derived from antipodal cyclobutanol intermediates.
J Org Chem
; 72(19): 7125-34, 2007 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17696474
15.
Pestalotiopsin A. Side chain installation and exhaustive probing of olefin metathesis as a possible tool for elaborating the cyclononene ring.
J Org Chem
; 72(19): 7135-47, 2007 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17696475
16.
Highly stereoselective beta-anomeric glycosidation of a 2'-deoxy syn-5'-configured 4'-spironucleoside.
J Org Chem
; 71(4): 1647-52, 2006 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-16468819
17.
Stereoselective synthesis of conformationally constrained 2'-deoxy-4'-thia beta-anomeric spirocyclic nucleosides featuring either hydroxyl configuration at C5'.
J Org Chem
; 70(5): 1580-96, 2005 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-15730276
18.
Stereoselective synthesis of beta-anomeric 4'-thiaspirocyclic ribonucleosides carrying the full complement of RNA-level hydroxyl substitution.
J Org Chem
; 70(14): 5655-64, 2005 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-15989350
19.
C4'-spiroalkylated nucleosides having sulfur incorporated at the apex position.
J Org Chem
; 68(22): 8625-34, 2003 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-14575495