Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates.

It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.

Today's Older Adults Are Cognitively Fitter Than Older Adults Were 20 Years Ago, but When and How They Decline Is No Different Than in the Past.

History-graded increases in older adults' levels of cognitive performance are well documented, but little is known about historical shifts in within-person change: cognitive decline and onset of decline. We combined harmonized perceptual-motor speed data from independent samples recruited in 1990 and 2010 to obtain 2,008 age-matched longitudinal observations (M = 78 years, 50% women) from 228 participants in the Berlin Aging Study (BASE) and 583 participants in the Berlin Aging Study II (BASE-II). We used nonlinear growth models that orthogonalized within- and between-person age effects and controlled for retest effects. At age 78, the later-born BASE-II cohort substantially outperformed the earlier-born BASE cohort (d = 1.20; 25 years of age difference). Age trajectories, however, were parallel, and there was no evidence of cohort differences in the amount or rate of decline and the onset of decline. Cognitive functioning has shifted to higher levels, but cognitive decline in old age appears to proceed similarly as it did two decades ago.

Historical change in trajectories of loneliness in old age: Older adults today are less lonely, but do not differ in their age trajectories.

To check claims of a "loneliness epidemic," we examined whether current cohorts of older adults report higher levels and/or steeper age-related increases in loneliness than earlier-born peers. Specifically, we used 1,068 age-matched longitudinal reports (Mage observations = 79 years, 49% women) of loneliness provided by independent samples recruited in the German city of Berlin in 1990 and 2010, n = 257 participants in the Berlin Aging Study (BASE) and n = 383 participants in Berlin Aging Study II (BASE-II). Using multilevel models that orthogonalize between-person and within-person age effects, we examined how responses to items from the UCLA Loneliness Scale provided by observation-matched cohorts differed with age and across cohorts, and if those differences might be explained by a variety of individual factors. Results revealed that at age 79, the later-born BASE-II cohort reported substantially lower levels of loneliness than the earlier-born BASE cohort (d = -0.84), with cohort differences accounting for more than 14% of the variance in loneliness. Age trajectories, however, were parallel without evidence of cohort differences in rates of within-person age-related changes in loneliness. Differences in gender, education, cognitive functioning, and external control beliefs accounted for the lion's share of cohort-related differences in levels of loneliness. Results show that loneliness among older adults has shifted to markedly lower levels today, but the rate at which loneliness increases with age proceeds similarly as 2 decades ago. Future studies should investigate how psychosocial functioning across the life course is progressing in different sociohistorical contexts and in other age groups, such as younger and middle-aged adults. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Stability and change of optimism and pessimism in late midlife and old age across three independent studies.

Research across a number of different areas in psychology has long shown that optimism and pessimism are predictive of a number of important future life outcomes. Despite a vast literature on the correlates and consequences, we know very little about how optimism and pessimism change across adulthood and old age and the sociodemographic factors that are associated with individual differences in such trajectories. In the present study, we conducted (parallel) analyses of standard items from the Life Orientation Test (Scheier & Carver, 1985) in three comprehensive data sets: Two-wave data from both the Berlin Aging Study II (N = 1,423, aged 60-88; M = 70.4, SD = 3.70) and the Midlife in the U.S. Study (N = 1,810 aged 60-84; M = 69.12, SD = 6.47) as well as cross-sectional data from the Survey of Health, Aging, and Retirement (N = 17,087, aged 60-99; M = 70.19, SD = 7.53). Using latent change-regression models and locally weighted smoothing curves revealed that optimism is on average very stable after age 60, with some evidence in Survey of Health, Aging, and Retirement of lowered optimism in very old age. Consistent across the three independent studies, pessimism evinced on average modest increases, ranging between .25 and .50 SD per 10 years of age. Of the sociodemographic factors examined, higher levels of education revealed the most consistent associations with lower pessimism, whereas gender evinced more study-specific findings. We take our results to demonstrate that age-related trajectories and correlates thereof differ for optimism and pessimism. Older adults appear to preserve into older ages those levels of optimistic expectations they have had at 60 years of age and show only modest increases in pessimism. We discuss possible reasons for these findings. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Context Matters: Health Sensitivity in the Daily Lives of Older Adults Living Through the COVID-19 Pandemic.

OBJECTIVES: Throughout 2021, the coronavirus disease (COVID-19) pandemic caused renewed restrictions across Germany. Given the growing evidence that the pandemic negatively affects older adults' health and well-being, this study investigated health sensitivity (emotional reactions to momentary health challenges) and its moderators (age, morbidity, perceived COVID-19 risks and worries) among older adults in their everyday lives during the second and third waves of the pandemic. METHODS: Multilevel models were applied to self-reported momentary health and affect data, collected 6 times per day across 7 consecutive days in 104 participants (Mage = 76.35; range: 67-88 years), assessed between April and June 2021 (~300,000 COVID-19 cases in Germany at the time). RESULTS: Health sensitivity was unrelated to age and lower with higher morbidity. Importantly, older adults showed higher health sensitivity in moments when they also perceived a greater risk of contracting COVID-19. DISCUSSION: Findings suggest that sociocontextual factors related to the pandemic modulate emotional reactions to momentary health challenges, thereby underscoring the consequences of COVID-19 for older adults' emotional experiences.

Age Trajectories of Perceptual Speed and Loneliness: Separating Between-Person and Within-Person Associations.

OBJECTIVES: We aimed at examining between-person and within-person associations across age trajectories of perceptual speed and loneliness in old age. METHOD: We applied multilevel models to 4 waves of data collected over 6 years from 1,491 participants of the Berlin Aging Study II (60-88 years at baseline, 50% women) to disentangle between-person and within-person associations across age trajectories of perceptual speed and both emotional and social loneliness. Sex and education were considered as relevant individual characteristics and included as covariates in the model. RESULTS: Analyses revealed that on average perceptual speed exhibited moderate within-person age-related declines, whereas facets of loneliness were rather stable. Perceptual speed did not predict age trajectories of emotional or social loneliness, at either the between- or within-person level. In contrast, loneliness discriminated individuals at the between-person level, such that those feeling emotionally or socially more lonely showed lower cognitive performance than those feeling emotionally or socially less lonely. Predictive effects of social loneliness were stronger for relatively young people (i.e., in their mid to late 60s) than for relatively older participants (i.e., in their 80s). In addition, predictive effects of social loneliness for perceptual speed at the within-person level were modest and deviated in direction and size from between-person social loneliness effects among those in their mid- to late 60s, whereas they did not among those in their 80s. DISCUSSION: We conclude that loneliness may serve as a precursor for basic cognitive functioning in old age and suggest routes for further inquiry.

Subjective age and attitudes toward own aging across two decades of historical time.

A large body of empirical evidence has accumulated showing that the experience of old age is "younger," more "agentic," and "happier" than ever before. However, it is not yet known whether historical improvements in well-being, control beliefs, cognitive functioning, and other outcomes generalize to individuals' views on their own aging process. To examine historical changes in such views on aging, we compared matched cohorts of older adults within two independent studies that assessed differences across a two-decade interval, the Berlin Aging Studies (BASE; 1990/1993 vs. 2017/2018, each n = 256, Mage = 77) and the Midlife in the United States Study (MIDUS; 1995/1996 vs. 2013/14, each n = 848, Mage = 67). Consistent across four different dimensions of individuals' subjective views on aging (age felt, age appeared, desired age, and attitudes toward own aging) in the BASE and corroborated with subjective age felt and subjective age desired in the MIDUS, there was no evidence whatsoever that older adults of today have more favorable views on how they age than older adults did two decades ago. Further, heterogeneity in views on aging increased across two decades in the MIDUS but decreased in BASE. Also consistent across studies, associations of views on aging with sociodemographic, health, cognitive, and psychosocial correlates did not change across historical times. We discuss possible reasons for our findings, including the possibility that individual age views may have become increasingly decoupled from societal age views. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Sociohistorical Change in Urban Older Adults' Perceived Speed of Time and Time Pressure.

OBJECTIVES: Perceptions of time are shaped by sociohistorical factors. Specifically, economic growth and modernization often engender a sense of acceleration. Research has primarily focused on one time perception dimension (perceived time pressure) in one subpopulation (working-age adults), but it is not clear whether historical changes extend to other dimensions (e.g., perceived speed of time) and other subpopulations, such as older adults who are no longer in the workforce and experience age-related shifts in time perception. We therefore examined sociohistorical and age-related trends in two dimensions of time perception in two cohorts of urban older adults. METHOD: Using propensity score matching for age and education, samples were drawn from the Berlin Aging Study (1990-1993, n = 256, Mage = 77.49) and the Berlin Aging Study-II (2009-2014, n = 248, Mage = 77.49). Cohort differences in means, variances, covariance, and correlates of perceived speed of time and time pressure were examined using multigroup SEM. RESULTS: There were no cohort differences in the perceived speed of time, but later-born cohorts reported more time pressure than earlier-born cohorts. There were no significant age differences, but perceptions of speed of time were more heterogeneous in the 1990s than in the 2010s. Cohorts did not differ in how time perceptions were associated with sociodemographic, health, cognitive, and psychosocial correlates. DISCUSSION: These findings document sociohistorical trends toward greater perceived time pressure and reduced heterogeneity in perceived speed of time among later-born urban adults. Conceptualizations of social acceleration should thus consider the whole adult life span.

Using blood test parameters to define biological age among older adults: association with morbidity and mortality independent of chronological age validated in two separate birth cohorts.

Biomarkers defining biological age are typically laborious or expensive to assess. Instead, in the current study, we identified parameters based on standard laboratory blood tests across metabolic, cardiovascular, inflammatory, and kidney functioning that had been assessed in the Berlin Aging Study (BASE) (n = 384) and Berlin Aging Study II (BASE-II) (n = 1517). We calculated biological age using those 12 parameters that individually predicted mortality hazards over 26 years in BASE. In BASE, older biological age was associated with more physician-observed morbidity and higher mortality hazards, over and above the effects of chronological age, sex, and education. Similarly, in BASE-II, biological age was associated with physician-observed morbidity and subjective health, over and above the effects of chronological age, sex, and education as well as alternative biomarkers including telomere length, DNA methylation age, skin age, and subjective age but not PhenoAge. We discuss the importance of biological age as one indicator of aging.

Dehydration predicts longitudinal decline in cognitive functioning and well-being among older adults.

Adequate hydration is essential for health, with even mild forms of dehydration often having negative effects on cognition and well-being. Despite evidence of higher risk for dehydration among older adults, links between dehydration and cognitive or well-being outcomes have not been established in old age. In this study, we used longitudinal data from the Berlin Aging Study II (age range 60-89) to investigate whether trajectories of cognitive functioning (digit symbol, N = 1,111) and well-being (Diener satisfaction with life, N = 1,066; Socio-Economic Panel Study life satisfaction, N = 1,067; and Lawton morale, N = 1,067) are associated with objective dehydration (osmolarity; 33% dehydrated). Our results revealed that higher dehydration was associated with steeper decline in cognitive functioning and well-being over time, and lower well-being among those with higher body mass index. These associations were independent of sociodemographic and physical health characteristics. Our findings highlight the importance of adequate hydration for preserved cognition and well-being across old age. We discuss potential mechanisms and consider practical implications arising from our results. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Trajectories of multiple subjective well-being facets across old age: The role of health and personality.

Subjective well-being is often characterized by average stability across old age, but individual differences are substantial and not yet fully understood. This study targets physical and cognitive health and personality as individual difference characteristics and examines their unique and interactive roles for level and change in a number of different facets of subjective well-being. We make use of medical diagnoses, performance-based indicators of physical (grip strength) and cognitive functioning (Digit Symbol), and extraversion and neuroticism and apply parallel sets of multilevel growth models to multiyear well-being data obtained in the Berlin Aging Study 2 (N = 1,216; Mage = 71; SD = 3.84; 51% women) and the German Socio-Economic Panel (N = 3,418; Mage = 70; SD = 6.89; 51% women). Results revealed by and large average stability of life satisfaction, morale, and emotions (anger, fear, sadness, happiness) across old age. Most important for our research questions, higher morbidity, poor performance on grip strength and perceptual speed tests, lower extraversion, and higher neuroticism were each uniquely associated with lower life satisfaction, morale, and positive affect and higher negative affect. Some evidence emerged for facet-specific health-personality interaction effects in predicting affective experiences, but effects observed were not consistent across studies and of small size. We take our findings to indicate that health and personality traits constitute important individual difference characteristics for our understanding of subjective well-being in old age and that these likely do not interact with one another to shape well-being. We discuss theoretical and practical implications. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Poor glucose regulation is associated with declines in well-being among older men, but not women.

Glucose regulation is a key aspect of healthy aging and has been linked to brain functioning and cognition. Here we examined the role of glucose regulation for within-person longitudinal trajectories of well-being. We applied growth models to data from the Berlin Aging Study II (N = 955), using insulin resistance as an index of glucoregulatory capacity. We found that poor glucose regulation (higher insulin resistance) was consistently associated with lower levels of well-being among older men but not women. Our study provides novel evidence for the relevance of glucose regulation for well-being among older men. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

Cohort differences in adult-life trajectories of internal and external control beliefs: A tale of more and better maintained internal control and fewer external constraints.

Life Span theory posits that sociohistorical contexts shape individual development. In line with this proposition, cohort differences favoring later-born cohorts have been widely documented for cognition and health. However, little is known about historical change in how key resources of psychosocial functioning such as control beliefs develop in old age. We pooled data from 3 independent samples: Berlin Aging Study (6 waves, N = 414); Interdisciplinary Longitudinal Study of Adult Development (4 waves, N = 925); and Berlin Aging Study II (4 waves, N = 1,111) to construct overlapping multiyear longitudinal data from ages 61 through 85 years for cohorts born 1905 to 1953 and examine historical changes in within-person trajectories of internal and external control beliefs. Results revealed that earlier-born cohorts exhibit age-related declines in internal control beliefs regarding both desirable and undesirable outcomes, whereas later-born cohorts perceive higher internal control and maintain this advantage into old age. Earlier-born cohorts also experience steep age-related increases in external control beliefs regarding both powerful others and chance, whereas later-born cohorts perceive lower external control and were stable across old age. Education and gender disparities in control beliefs narrowed over historical time. Sociodemographic, physical health, cognitive, and social factors explained some of the differences in control beliefs, and accounted for sizable portions of cohort effects. Our results indicate that current generations of older adults perceive more and better maintained internal control and fewer external constraints. We discuss potential underlying mechanisms and consider conceptual and societal implications of our findings. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Secular changes in late-life cognition and well-being: Towards a long bright future with a short brisk ending?

How sociocultural contexts shape individual functioning is of prime interest for psychological inquiry. Secular increases favoring later-born cohorts in fluid intelligence measures are widely documented for young adults. In the current study, we quantified such trends in old age using data from highly comparable participants living in a narrowly defined geographical area and examined whether these trends would generalize to quality-of-life indicators. To do so, we compared data obtained 20 years apart in the Berlin Aging Study (in 1990-1993) and the Berlin Aging Study II (in 2013-2014), applied a case-matched control design (per cohort, n = 161, Mage = 75), quantified sample selection using a nationally representative sample as the reference, and controlled for number of physical diseases. The later cohort performed better on the fluid intelligence measure (d = .85) and reported higher morale, less negative affect, and more positive affect (ds > .39) than the earlier cohort. We concluded that secular advances have resulted in better cognitive performance and perceived quality of life among older adults and discuss when and how advantages of later cohorts reach their limits.