Detalhe da pesquisa
1.
Methylpyrrole inhibitors of BET bromodomains.
Bioorg Med Chem Lett
; 27(10): 2225-2233, 2017 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28268136
2.
The Bcl-2 family antagonist ABT-737 significantly inhibits multiple animal models of autoimmunity.
J Immunol
; 182(12): 7482-9, 2009 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19494271
3.
An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
Nature
; 435(7042): 677-81, 2005 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15902208
4.
Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity.
Lancet Oncol
; 11(12): 1149-59, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21094089
5.
Structure-Based Design of A-1293102, a Potent and Selective BCL-XL Inhibitor.
ACS Med Chem Lett
; 12(6): 1011-1016, 2021 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141086
6.
Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers.
Mol Cancer Ther
; 20(6): 999-1008, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33785651
7.
N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Bioorg Med Chem Lett
; 20(24): 7503-6, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21106457
8.
Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
Bioorg Med Chem Lett
; 20(22): 6587-91, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20870405
9.
Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor.
ACS Med Chem Lett
; 11(10): 1829-1836, 2020 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33062160
10.
Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models.
Clin Cancer Res
; 14(11): 3268-77, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18519752
11.
ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo.
Mol Cancer Ther
; 7(10): 3265-74, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18852130
12.
Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
J Med Chem
; 50(4): 641-62, 2007 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17256834
13.
Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies.
Cancer Res
; 77(11): 2976-2989, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28416490
14.
Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
J Med Chem
; 60(9): 3828-3850, 2017 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28368119
15.
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.
J Med Chem
; 60(20): 8369-8384, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28949521
16.
Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis.
J Med Chem
; 49(2): 656-63, 2006 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-16420051
17.
Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
J Med Chem
; 49(3): 1165-81, 2006 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16451081
18.
A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects.
Mol Endocrinol
; 17(5): 860-9, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12586843
19.
MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor.
Mol Cancer Ther
; 14(8): 1837-47, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26013319
20.
Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.
J Med Chem
; 58(5): 2180-94, 2015 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25679114