Assuntos
COVID-19 , Linfoma Cutâneo de Células T , Neoplasias Cutâneas , Humanos , Pandemias , Estudos Retrospectivos , Linfoma Cutâneo de Células T/epidemiologia , Linfoma Cutâneo de Células T/terapia , Linfoma Cutâneo de Células T/patologia , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/patologiaRESUMO
There are no established maintenance protocols for cutaneous lymphomas. We aim to determine patient treatments and outcomes during the COVID-19 pandemic in order to uncover the most effective maintenance protocols for cutaneous lymphomas and impact of treatment interruption. Data was collected retrospectively from nine international institutions, including 149 patients. Younger patients had earlier stages of disease and were most frequently treated with skin-directed therapies including topical steroids, mechlorethamine gel, and phototherapy. Treatment interruption varied by treatment type and stage, with patients on topical therapies and earlier stages of disease being least likely to experience interruption. Treatment interruption was significantly associated with progression of disease and worse outcomes, with twice as many patients progressing who had interruption compared to those without interruption. This study may demonstrate the significance of continuous maintenance therapies, even in younger patients with early stages of disease.
RESUMO
El aburrimiento crónico (acidia) es un estado espiritual negativo del ser humano, constituido por una combinación de apatía e intranquilidad, el cual lo lleva a oscilar entre la depresión y la búsqueda frenética de distracciones de carácter autodestructivo. Además, su combinación con rasgos psicopáticos deviene en el cultivo de la malevolencia como forma aberrante de distracción. Gustave Flaubert reflejó perfectamente esta condición en el personaje de Emma en su obra Madame Bovary. (AU)
Chronic boredom (acedia) is a negative spiritual state of man, consisting of a combination of apathy and restlessness, which leads him/her to oscillate between depression and the frantic search for distractions of self-destructive character. Additionally, its combination with the presence of psychopathic traits leads do evil as a way to relieve boredom. Gustave Flaubert perfectly reflected this condition in the character of Emma in his masterpiece Madame Bovary. (AU)
Assuntos
Humanos , Tédio , Literatura , Arte , Comportamento Autodestrutivo/psicologia , Depressão/psicologia , Apatia , Transtorno da Personalidade Antissocial/psicologiaRESUMO
La imaginación y la fantasía son actividades psíquicas cuyo papel fundamental es el de generar imágenes que permitan concretar los procesos de percepción, reflexión y previsión, así como la adquisición del concepto de identidad. Carl Jung jerarquizó el valor de la imaginación en el psiquismo humano y plasmó en El libro rojo las imágenes fantásticas que luego serían la materia prima de sus teorías científicas. (AU)
Imagination and fantasy are psychic activities whose primary role is to generate images that allow concrete processes of perception, reflection, and foresight, and the acquisition of the concept of identity. Carl Jung ranks the value of imagination in the human psyche and delivers in his Red Book fantastic images that will be the raw material of his scientific theories. (AU)
Assuntos
Humanos , Fantasia , Imaginação , Percepção , Arte , PensamentoRESUMO
A través de su técnica pictórica, Giuseppe Arcimboldo nos muestra cómo la solidaridad es un principio universal que logra que, de la armonía de la multiplicidad y diversidad de lo simple, pueda surgir la complejidad de lo grandioso. (AU)
Through his painting technique, Giuseppe Arcimboldo shows how solidarity is a universal principle that achieves the harmony of the multiplicity and diversity of the simple, from which may arise the complexity of the great. (AU)
Assuntos
Humanos , Arte , Características Humanas , Solidariedade , Pinturas/psicologiaRESUMO
A través de la poesía de sus heterónimos, Fernando Pessoa nos muestra cómo el ser humano necesita trasformar la mera existencia en el creativo juego de la vida. (AU)
Through the poetry of his heterónimos, Fernando Pessoa shows how human beings need to transform the mere existence in the creative game of life.
Assuntos
Humanos , Arte , Ciências Humanas , Poesia como Assunto , LiteraturaRESUMO
A través de su obra de teatro Esperando a Godot, Samuel Becket nos hace reflexionar acerca de la naturaleza dual de la esperanza, no solo fuente de acción sino también potencial soporte del estancamiento. (AU)
Through his play Waiting for Godot, Samuel Beckett makes us to think about the dual nature of hope, not only fount of action but also potential source of stagnation. (AU)