Detalhe da pesquisa
1.
Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
Nat Chem Biol
; 15(8): 846, 2019 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-31267096
2.
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
Nat Chem Biol
; 15(7): 672-680, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31178587
3.
Protein degradation for drug discovery.
Drug Discov Today Technol
; 31: 1-3, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31200853
4.
Crystallization of VHL-based PROTAC-induced ternary complexes.
Methods Enzymol
; 681: 241-263, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36764760
5.
Breaking free from the crystal lattice: Structural biology in solution to study protein degraders.
Curr Opin Struct Biol
; 79: 102534, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36804675
6.
A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.
Nat Commun
; 13(1): 5969, 2022 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36216795
7.
Transforming targeted cancer therapy with PROTACs: A forward-looking perspective.
Curr Opin Pharmacol
; 57: 175-183, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33799000
8.
Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H).
J Med Chem
; 64(16): 12228-12244, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34387987
9.
Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice.
Sci Rep
; 10(1): 17081, 2020 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33051477
10.
N to C aryl migration in lithiated carbamates: alpha-arylation of benzylic alcohols.
J Am Chem Soc
; 131(10): 3410-1, 2009 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19275248
11.
SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate.
ACS Chem Biol
; 14(3): 361-368, 2019 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30721025
12.
Identification of compounds acting as negative allosteric modulators of the LPA1 receptor.
Eur J Pharmacol
; 833: 8-15, 2018 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29807028
13.
Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery.
Chem Commun (Camb)
; 53(91): 12345-12348, 2017 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29099137
14.
Assessing molecular scaffolds for CNS drug discovery.
Drug Discov Today
; 22(7): 965-969, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28111331
15.
Synthesis of (-)-(S,S)-clemastine by invertive N --> C aryl migration in a lithiated carbamate.
Org Lett
; 12(10): 2222-5, 2010 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20405879