Detalhe da pesquisa
1.
Discovery of potent iminoheterocycle BACE1 inhibitors.
Bioorg Med Chem Lett
; 24(23): 5455-9, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25455483
2.
Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor.
Bioorg Med Chem Lett
; 22(7): 2444-9, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22390835
3.
The synthesis and structure-activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists.
Bioorg Med Chem Lett
; 20(17): 5004-8, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20685118
4.
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.
Bioorg Med Chem Lett
; 20(9): 2837-42, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20347593
5.
Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability.
Bioorg Med Chem Lett
; 19(21): 6032-7, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19800786
6.
Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 18(1): 215-9, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17988864
7.
Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety.
J Med Chem
; 61(23): 10700-10708, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30388368
8.
Supercritical fluid chromatography/tandem mass spectrometric method for analysis of pharmaceutical compounds in metabolic stability samples.
J Pharm Biomed Anal
; 40(3): 799-804, 2006 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-16095863
9.
Structure-Based Design of an Iminoheterocyclic ß-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aß in Nonhuman Primates.
J Med Chem
; 59(7): 3231-48, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26937601
10.
Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists.
J Med Chem
; 48(3): 680-93, 2005 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-15689153
11.
Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor that Affords Robust CNS Aß Reduction.
ACS Med Chem Lett
; 3(11): 897-902, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23412139
12.
Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformation.
J Med Chem
; 55(21): 9331-45, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22989333
13.
Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation.
J Med Chem
; 53(3): 951-65, 2010 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20043696
14.
Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 17(19): 5330-5, 2007 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17761417
15.
Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold.
Bioorg Med Chem Lett
; 16(2): 395-9, 2006 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16246552
16.
Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists.
Bioorg Med Chem Lett
; 16(4): 989-94, 2006 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16297617
17.
Chiral supercritical fluid chromatography/tandem mass spectrometry for the simultaneous determination of pindolol and propranolol in metabolic stability samples.
Rapid Commun Mass Spectrom
; 19(21): 3037-41, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16193537