Detalhe da pesquisa
1.
Remote functionalization of SCH 39166: discovery of potent and selective benzazepine dopamine D1 receptor antagonists.
Bioorg Med Chem Lett
; 20(3): 832-5, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20064718
2.
Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists.
Bioorg Med Chem Lett
; 20(3): 836-40, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20061148
3.
Design and discovery of 1,3-benzodiazepines as novel dopamine antagonists.
Bioorg Med Chem Lett
; 19(17): 5218-21, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19643610
4.
Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: part 2.
Bioorg Med Chem Lett
; 19(4): 1164-7, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19147350
5.
Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety.
Bioorg Med Chem Lett
; 19(9): 2482-6, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19332374
6.
The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety.
Bioorg Med Chem Lett
; 19(9): 2519-23, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19339177
7.
Effect of a novel NOP receptor agonist (SCH 225288) on guinea pig irritant-evoked, feline mechanically induced and canine infectious tracheobronchitis cough.
Pharmacology
; 84(3): 153-61, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19696521
8.
The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510).
J Pharmacol Exp Ther
; 326(2): 672-82, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18492950
9.
Minocycline protects photoreceptors from light and oxidative stress in primary bovine retinal cell culture.
Invest Ophthalmol Vis Sci
; 48(1): 412-21, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17197562
10.
Protective effect of crocin against blue light- and white light-mediated photoreceptor cell death in bovine and primate retinal primary cell culture.
Invest Ophthalmol Vis Sci
; 47(7): 3156-63, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16799063
11.
Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists.
J Med Chem
; 48(3): 680-93, 2005 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-15689153
12.
Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity.
PLoS One
; 10(5): e0124940, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25970164
13.
Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models.
Eur J Pharmacol
; 630(1-3): 112-20, 2010 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20006596
14.
Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands.
Bioorg Med Chem Lett
; 17(8): 2281-4, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17289383
15.
Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1.
Bioorg Med Chem Lett
; 17(11): 3023-7, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17428659
16.
Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2.
Bioorg Med Chem Lett
; 17(11): 3028-33, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17420123
17.
Protective effects of myricetin and related flavonols against A2E and light mediated-cell death in bovine retinal primary cell culture.
Exp Eye Res
; 85(1): 154-65, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17544396
18.
Modification of the clozapine structure by parallel synthesis.
Bioorg Med Chem Lett
; 16(17): 4548-53, 2006 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16806922
19.
6-(2-Furanyl)-9H-purin-2-amine derivatives as A2A adenosine antagonists.
Bioorg Med Chem Lett
; 15(8): 2119-22, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15808481
20.
2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs: highly potent, orally active, adenosine A2A antagonists. Part 1.
Bioorg Med Chem Lett
; 15(16): 3670-4, 2005 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15978806