RESUMO
Serum samples were collected from 328 healthy American Blacks and from 61 American Blacks with systemic lupus erythematosus (SLE). Sera were typed for the Gm1,2,3,5,6,13,17, and 21 allotypes as well as for the Km(1) allotype. The frequency of Gm phenotype 1,17;5,6,13 was significantly increased in the SLE patients (p = 0.0001, RR = 3.19, EF = 0.29). Our data suggest the existence of at least two immunoglobulin allotype associated genes that somehow interact to increase susceptibility to SLE in Blacks. To our knowledge, this is the first report of an association of Gm and SLE in Blacks.
Assuntos
População Negra , Alótipos de Imunoglobulina/análise , Imunoglobulina G/análise , Lúpus Eritematoso Sistêmico/imunologia , Suscetibilidade a Doenças , Frequência do Gene , Humanos , Alótipos de Imunoglobulina/genética , Imunoglobulina G/genética , Lúpus Eritematoso Sistêmico/etiologia , Lúpus Eritematoso Sistêmico/genética , Fenótipo , Estados UnidosRESUMO
The ubiquitous Aspergillus fungus has numerous manifestations when associated with lung disease (primary Aspergillus pneumonia, aspergilloma, allergic bronchopulmonary aspergillosis, and invasive Aspergillus). This fungus also can colonize preexisting lung disease in an indolent manner and then acutely assume a more invasive nature. Although the species Aspergillus niger is infrequently encountered, the endobronchial visualization of black necrotic debris or a fungus ball or the finding of black acidic sputum or pleural fluid suggests the presence of A niger and the destructive by-product of its fermentation, oxalic acid.
Assuntos
Aspergilose/complicações , Aspergillus niger , Pneumopatias Fúngicas/complicações , Pneumopatias Obstrutivas/complicações , Oxalatos/análise , Aspergilose/diagnóstico por imagem , Aspergilose/metabolismo , Aspergilose/patologia , Cristalização , Humanos , Pulmão/metabolismo , Pulmão/patologia , Pneumopatias Fúngicas/diagnóstico por imagem , Pneumopatias Fúngicas/metabolismo , Pneumopatias Fúngicas/patologia , Masculino , Pessoa de Meia-Idade , Infecção por Mycobacterium avium-intracellulare/complicações , Infecção por Mycobacterium avium-intracellulare/patologia , Radiografia , Doenças Torácicas/microbiologia , Doenças Torácicas/patologiaRESUMO
Fifty-five unrelated whites with disorders in the scleroderma spectrum who had both antinuclear antibodies and Raynaud's phenomenon (RP) were studied. Of the 22 patients with anticentromere antibody (ACA), three had diffuse scleroderma; 16 had the complete or incomplete syndrome of calcinosis, RP, esophageal dysmotility, sclerodactyly, and telangiectasia (CREST syndrome); and three had RP only. Thirty-three patients with other nuclear patterns all had systemic scleroderma (28 diffuse scleroderma, five CREST syndrome). Patients with ACA had less organ system involvement, and lower frequencies of anemia and elevation of sedimentation rate than ACA-negative patients, but these differences were not statistically significant. They also had fewer manifestations of CREST syndrome. All 55 patients were studied for the Gm and Km allotypic markers. No association was found between Gm or Km allotypic markers and scleroderma or between the allotypic markers and the presence of ACA.
Assuntos
Anticorpos/análise , Centrômero/imunologia , Cromossomos/imunologia , Alótipos de Imunoglobulina/análise , Escleroderma Sistêmico/imunologia , Adolescente , Adulto , Idoso , Anticorpos Antinucleares/análise , Feminino , Imunofluorescência , Humanos , Masculino , Pessoa de Meia-Idade , Doença de Raynaud/imunologia , Escleroderma Sistêmico/complicaçõesRESUMO
Gm and Km immunoglobulin allotypes were studied in 46 Caucasian patients with Charcot-Marie-Tooth disease (CMT). No significant association of Gm and Km phenotypes with CMT was found. Family studies revealed that Gm haplotypes and CMT were not inherited together, thus arguing against the involvement of immunoglobulin allotypes in CMT.
Assuntos
Doença de Charcot-Marie-Tooth/genética , Alótipos de Imunoglobulina/análise , Imunoglobulina G/genética , Atrofia Muscular/genética , Doença de Charcot-Marie-Tooth/imunologia , Mapeamento Cromossômico , Humanos , FenótipoRESUMO
Several immunoglobulin allotypes were determined for 42 Finnish children with celiac disease (CD) and for 42 normal controls. The CD patients had been previously HLA typed; all but 2 were positive for HLA B8, DR3 or both. The incidence of HLA B8, DR3 and DR7 was found to be significantly higher in patients than in a control group. No significant association was found between any of the immunoglobulin allotypes and CD either when patients were grouped as a whole or when grouped according to sex. In addition, no association was found between levels of antigliadin antibody and the G2m(23) allotypic marker. This latter finding is in sharp contrast with the report of a significant association in American Caucasians between G2m(23) and the level of antigliadin antibodies by Weiss et al. [J. clin. Invest. 72: 96-101, 1983].
Assuntos
Biomarcadores/análise , Doença Celíaca/imunologia , Gliadina/imunologia , Antígenos HLA/análise , Alótipos de Imunoglobulina/análise , Proteínas de Plantas/imunologia , Adolescente , Doença Celíaca/etnologia , Doença Celíaca/genética , Criança , Pré-Escolar , Suscetibilidade a Doenças , Etnicidade , Feminino , Finlândia , Antígenos HLA/genética , Humanos , Alótipos de Imunoglobulina/genética , Masculino , Fenótipo , Fatores SexuaisRESUMO
Serum samples from 121 unrelated, healthy Japanese individuals were typed for several Gm and Km(1) allotypes. Peripheral blood lymphocytes from these subjects were cultured with streptococcal cell wall (SCW) antigen and the incorporation of 3H-thymidine into T lymphoblasts was measured. Log-linear analysis showed a significant interactive effect of Gm1,17;13,16,21 and Km(1) on the cellular immune response to group A SCW antigen.