RESUMO
Three new monoterpene glycosides (1-3) and eleven known compounds (4-14) were isolated from seeds of Helianthus annuus L. (sunflower). Their structures were determined by spectroscopic and chemical methods. All the compounds were isolated from sunflower seeds for the first time. Protective effects of compounds 1-14 against H2O2-induced H9c2 cardiomyocyte injury were evaluated, and compounds 1 and 2 showed some cell-protective effects. No significant DPPH radical scavenging activity was observed for compounds 1-14.
Assuntos
Sequestradores de Radicais Livres/isolamento & purificação , Glicosídeos/isolamento & purificação , Helianthus/química , Peróxido de Hidrogênio/farmacologia , Monoterpenos/isolamento & purificação , Miócitos Cardíacos/efeitos dos fármacos , Animais , Compostos de Bifenilo/química , Linhagem Celular , Sobrevivência Celular/efeitos dos fármacos , Sequestradores de Radicais Livres/farmacologia , Glicosídeos/farmacologia , Monoterpenos/farmacologia , Picratos/química , Ratos , Sementes/químicaRESUMO
In this paper, the method of interfacial polymerization in emulsion was employed to fabricate chondroitin sulfate-methacrylate (ChSMA) nanocapsules, in which poor water-soluble drug of indomethacin (IND) could be effectively encapsulated. The morphology and the size distribution of synthesized nanocapsules were characterized by field emission scanning electron microscopy (FESEM) and dynamic light scattering (DLS) techniques. The quantitative drug loading was investigated. The IND/ChSMA noodle-like self-assemblies were observed with the increase of IND feed concentration, and the interactions between IND and ChSMA were illuminated by FT-IR and XRD measurements. The in vitro drug release of IND-loaded nanocapsules and IND/ChSMA self-assemblies were also carried out in simulated body fluid pH 7.4 at 37°C.