Detalhe da pesquisa
1.
Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor.
Antimicrob Agents Chemother
; 56(6): 3324-35, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22391531
2.
Distinct mutation pathways of non-subtype B HIV-1 during in vitro resistance selection with nonnucleoside reverse transcriptase inhibitors.
Antimicrob Agents Chemother
; 54(11): 4812-24, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20805392
3.
Total synthesis, characterization, and conformational analysis of the naturally occurring hexadecapeptide integramide A and a diastereomer.
Chemistry
; 16(1): 316-27, 2010 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-19937615
4.
Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif.
Bioorg Med Chem Lett
; 20(15): 4328-32, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20609585
5.
Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants.
Bioorg Med Chem Lett
; 19(17): 5119-23, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19631528
6.
Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors.
J Med Chem
; 51(4): 861-74, 2008 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18217703
7.
Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 18(2): 721-5, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18078751
8.
Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.
Bioorg Med Chem Lett
; 18(19): 5307-10, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18774711
9.
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations.
Bioorg Med Chem Lett
; 18(9): 2959-66, 2008 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18396399
10.
10-Hydroxy-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants.
Bioorg Med Chem Lett
; 18(16): 4581-3, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18657970
11.
8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 17(23): 6511-5, 2007 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17931865
12.
Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group.
ACS Med Chem Lett
; 7(7): 702-7, 2016 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27437081
13.
Complete absolute configuration of integramide A, a natural, 16-mer peptide inhibitor of HIV-1 integrase, elucidated by total synthesis.
Chembiochem
; 10(1): 87-90, 2009 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-18850604
14.
Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.
J Med Chem
; 46(4): 453-6, 2003 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-12570367
15.
Integramides A and B, two novel non-ribosomal linear peptides containing nine C(alpha)-methyl amino acids produced by fungal fermentations that are inhibitors of HIV-1 integrase.
Org Lett
; 4(9): 1431-4, 2002 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-11975596
16.
Isolation, structure and HIV-1 integrase inhibitory activity of exophillic acid, a novel fungal metabolite from Exophiala pisciphila.
J Antibiot (Tokyo)
; 56(12): 1018-23, 2003 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15015729
17.
Triple HypâPro replacement in integramide A, a peptaib inhibitor of HIV-1 integrase: Effect on conformation and bioactivity.
Biopolymers
; 96(1): 49-59, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-20560143
18.
Biaryl ethers as novel non-nucleoside reverse transcriptase inhibitors with improved potency against key mutant viruses.
J Med Chem
; 52(22): 7163-9, 2009 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19883100
19.
Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses.
J Med Chem
; 51(20): 6503-11, 2008 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-18826204
20.
Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 17(20): 5595-9, 2007 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17822898