Detalhe da pesquisa
1.
Concentration-QT modelling of the novel DHFR inhibitor P218 in healthy male volunteers.
Br J Clin Pharmacol
; 88(1): 128-137, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34075612
2.
Detection and impact of hysteresis when evaluating a drug's QTc effect using concentration-QTc analysis.
J Pharmacokinet Pharmacodyn
; 48(2): 187-202, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33118135
3.
Cardiac risk assessment based on early Phase I data and PK-QTc analysis is concordant with the outcome of thorough QTc trials: an assessment based on eleven drug candidates.
J Pharmacokinet Pharmacodyn
; 46(6): 617-626, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31667657
4.
Correction to: Scientific white paper on concentration-QTc modeling.
J Pharmacokinet Pharmacodyn
; 45(3): 399, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29330761
5.
Scientific white paper on concentration-QTc modeling.
J Pharmacokinet Pharmacodyn
; 45(3): 383-397, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29209907
6.
Thorough QT study of the effect of intravenous amisulpride on QTc interval in Caucasian and Japanese healthy subjects.
Br J Clin Pharmacol
; 83(2): 339-348, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27618796
7.
Stability of the Effect of a Standardized Meal on QTc.
Ann Noninvasive Electrocardiol
; 22(1)2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27233583
8.
Evaluation of the QT effect of a combination of piperaquine and a novel anti-malarial drug candidate OZ439, for the treatment of uncomplicated malaria.
Br J Clin Pharmacol
; 80(4): 706-15, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25966781
9.
Detection of QTc effects in small studies--implications for replacing the thorough QT study.
Ann Noninvasive Electrocardiol
; 20(4): 368-77, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25367715
10.
Thorough QT study of the effect of oral moxifloxacin on QTc interval in the fed and fasted state in healthy Japanese and Caucasian subjects.
Br J Clin Pharmacol
; 77(1): 170-9, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23713767
11.
The IQ-CSRC prospective clinical Phase 1 study: "Can early QT assessment using exposure response analysis replace the thorough QT study?".
Ann Noninvasive Electrocardiol
; 19(1): 70-81, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24372708
12.
Insulin at normal physiological levels does not prolong QT(c) interval in thorough QT studies performed in healthy volunteers.
Br J Clin Pharmacol
; 75(2): 392-403, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22775199
13.
Lomitapide at supratherapeutic plasma levels does not prolong the Qtc interval--results from a TQT study with moxifloxacin and ketoconazole.
Ann Noninvasive Electrocardiol
; 18(6): 577-89, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24118671
14.
Pattern recognition analysis of digital ECGs: decreased QT measurement error and improved precision compared to semi-automated methods.
J Electrocardiol
; 46(2): 118-25, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23266069
15.
Pridopidine Does Not Significantly Prolong the QTc Interval at the Clinically Relevant Therapeutic Dose.
Neurol Ther
; 12(2): 597-617, 2023 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-36811812
16.
Comparison of the effects of levofloxacin on QT/QTc interval assessed in both healthy Japanese and Caucasian subjects (pages.
Br J Clin Pharmacol
; 73(3): 455-9, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22442827
17.
How to improve walking, balance and social participation following stroke: a comparison of the long term effects of two walking aids--canes and an orthosis TheraTogs--on the recovery of gait following acute stroke. A study protocol for a multi-centre, single blind, randomised control trial.
BMC Neurol
; 12: 18, 2012 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22462692
18.
ECG Evaluation as Part of the Clinical Pharmacology Strategy in the Development of New Drugs: A Review of Current Practices and Opportunities Based on Five Case Studies.
J Clin Pharmacol
; 62(12): 1480-1500, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35665514
19.
The New S7B/E14 Question and Answer Draft Guidance for Industry: Contents and Commentary.
J Clin Pharmacol
; 61(10): 1261-1273, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33896027
20.
Electrophysiological and ECG Effects of Perhexiline, a Mixed Cardiac Ion Channel Inhibitor, Evaluated in Nonclinical Assays and in Healthy Subjects.
J Clin Pharmacol
; 61(12): 1606-1617, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34214210