Detalhe da pesquisa
1.
Direct quantification of in vivo mutagenesis and carcinogenesis using duplex sequencing.
Proc Natl Acad Sci U S A
; 117(52): 33414-33425, 2020 12 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33318186
2.
Nonclinical Safety Profile of Etelcalcetide, a Novel Peptide Calcimimetic for the Treatment of Secondary Hyperparathyroidism.
Int J Toxicol
; 35(3): 294-308, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26941242
3.
Retinal Toxicity Induced by a Novel ß-secretase Inhibitor in the Sprague-Dawley Rat.
Toxicol Pathol
; 43(4): 581-92, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25361751
4.
Evaluation of genotoxicity testing of FDA approved large molecule therapeutics.
Regul Toxicol Pharmacol
; 70(1): 87-97, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24932799
5.
Characterization of xenobiotic-induced hepatocellular enzyme induction in rats: anticipated thyroid effects and unique pituitary gland findings.
Toxicol Pathol
; 39(4): 664-77, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21551028
6.
Biomarkers of genome instability in normal mammalian genomes following drug-induced replication stress.
Environ Mol Mutagen
; 61(8): 770-785, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32078182
7.
The liver pharmacological and xenobiotic gene response repertoire.
Mol Syst Biol
; 4: 175, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18364709
8.
Validation of putative genomic biomarkers of nephrotoxicity in rats.
Toxicology
; 246(2-3): 91-100, 2008 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-18289764
9.
Modernizing Human Cancer Risk Assessment of Therapeutics.
Trends Pharmacol Sci
; 39(3): 232-247, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29242029
10.
A gene expression biomarker provides early prediction and mechanistic assessment of hepatic tumor induction by nongenotoxic chemicals.
Toxicol Sci
; 99(1): 90-100, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17557906
11.
Development of 2-aminooxazoline 3-azaxanthene ß-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D.
Medchemcomm
; 8(6): 1196-1206, 2017 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108829
12.
The state-of-the-art in predictive toxicogenomics.
Curr Opin Drug Discov Devel
; 9(1): 84-91, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16445120
13.
Preclinical drug safety analysis by chemogenomic profiling in the liver.
Am J Pharmacogenomics
; 5(3): 161-71, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15952870
14.
Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action.
J Biotechnol
; 119(3): 219-44, 2005 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16005536
15.
Gestational and lactational exposure of male mice to diethylstilbestrol causes long-term effects on the testis, sperm fertilizing ability in vitro, and testicular gene expression.
Endocrinology
; 143(8): 3044-59, 2002 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12130571
16.
Normal mammary gland morphology in pubertal female mice following in utero and lactational exposure to genistein at levels comparable to human dietary exposure.
Toxicol Lett
; 133(2-3): 181-91, 2002 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12119126
17.
Development and evaluation of a genomic signature for the prediction and mechanistic assessment of nongenotoxic hepatocarcinogens in the rat.
Toxicol Sci
; 124(1): 54-74, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21813463
18.
Mechanism of subendocardial cell proliferation in the rat and relevance for understanding drug-induced valvular heart disease in humans.
Exp Toxicol Pathol
; 62(6): 607-13, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19781924
19.
The role of early in vivo toxicity testing in drug discovery toxicology.
Expert Opin Drug Saf
; 7(2): 107-10, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18324874
20.
Authors' response to letter to the editor on "image cytometry protocols".
J Histochem Cytochem
; 61(10): 761-2, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24084868