Detalhe da pesquisa
1.
Efficacy of therapeutically administered gepotidacin in a rabbit model of inhalational anthrax.
Antimicrob Agents Chemother
; 68(3): e0149723, 2024 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38358266
2.
Efficacy of Intravenously Administered Gepotidacin in Cynomolgus Macaques following a Francisella tularensis Inhalational Challenge.
Antimicrob Agents Chemother
; 67(5): e0138122, 2023 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37097147
3.
Novel Bacterial Topoisomerase Inhibitor Gepotidacin Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats.
Antimicrob Agents Chemother
; 66(11): e0048322, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36255258
4.
Nonproliferative and Proliferative Lesions of the Ratand Mouse Special Sense Organs(Ocular [eye and glands], Olfactory and Otic).
J Toxicol Pathol
; 31(3 Suppl): 97S-214S, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30158741
5.
A phase I, first-in-human study investigating the safety, tolerability, and pharmacokinetics of the maturation inhibitor GSK3739937.
Pharmacol Res Perspect
; 11(3): e01093, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37269076
6.
Gepotidacin is efficacious in a nonhuman primate model of pneumonic plague.
Sci Transl Med
; 14(647): eabg1787, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35648812
7.
Use of the ZDF rat to model dietary fat induced hypercoagulability is limited by progressive and fatal nephropathy.
J Pharmacol Toxicol Methods
; 107: 106933, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33122074
8.
Immune complex disease in a chronic monkey study with a humanised, therapeutic antibody against CCL20 is associated with complement-containing drug aggregates.
PLoS One
; 15(4): e0231655, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32325480
9.
Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2.
J Pharmacol Exp Ther
; 326(2): 443-52, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18499744
10.
Non-Lethal Endotoxin Injection: A Rat Model of Hypercoagulability.
PLoS One
; 12(1): e0169976, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28081568