Detalhe da pesquisa
1.
Nocathiacin, Thiazomycin, and Polar Analogs Are Highly Effective Agents against Toxigenic Clostridioides difficile.
J Nat Prod
; 85(4): 1141-1146, 2022 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35380836
2.
Ibrexafungerp: An orally active ß-1,3-glucan synthesis inhibitor.
Bioorg Med Chem Lett
; 32: 127661, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33160023
3.
MK-5204: An orally active ß-1,3-glucan synthesis inhibitor.
Bioorg Med Chem Lett
; 30(17): 127357, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32738971
4.
Use of Translational Pharmacokinetic/Pharmacodynamic Infection Models To Understand the Impact of Neutropenia on the Efficacy of Tedizolid Phosphate.
Antimicrob Agents Chemother
; 63(1)2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30373794
5.
Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidiasis.
Antimicrob Agents Chemother
; 61(4)2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28137806
6.
Disease Progression and Resolution in Rodent Models of Clostridium difficile Infection and Impact of Antitoxin Antibodies and Vancomycin.
Antimicrob Agents Chemother
; 60(11): 6471-6482, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27527088
7.
Novel orally active inhibitors of ß-1,3-glucan synthesis derived from enfumafungin.
Bioorg Med Chem Lett
; 25(24): 5813-8, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26542966
8.
Kibdelomycin is a potent and selective agent against toxigenic Clostridium difficile.
Antimicrob Agents Chemother
; 58(4): 2387-92, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24514098
9.
A rapid method for cross-species quantitation of apolipoproteins A1, B48 and B100 in plasma by ultra-performance liquid chromatography/tandem mass spectrometry.
Rapid Commun Mass Spectrom
; 26(2): 101-8, 2012 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22173797
10.
Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J Med Chem
; 65(24): 16234-16251, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36475645
11.
Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis.
Antimicrob Agents Chemother
; 55(7): 3491-7, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21518846
12.
Chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension.
Clin Exp Hypertens
; 33(8): 538-47, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21950654
13.
PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products.
Chem Biol
; 15(4): 363-74, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18420143
14.
Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch Disrupt Riboflavin Homeostasis in an Infectious Setting.
Cell Chem Biol
; 24(5): 576-588.e6, 2017 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28434876
15.
Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.
J Med Chem
; 60(9): 3851-3865, 2017 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28322556
16.
TarO-specific inhibitors of wall teichoic acid biosynthesis restore ß-lactam efficacy against methicillin-resistant staphylococci.
Sci Transl Med
; 8(329): 329ra32, 2016 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26962156
17.
Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis.
ACS Infect Dis
; 1(1): 59-72, 2015 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26878058
18.
Discovery of wall teichoic acid inhibitors as potential anti-MRSA ß-lactam combination agents.
Chem Biol
; 20(2): 272-84, 2013 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23438756
19.
Murgocil is a highly bioactive staphylococcal-specific inhibitor of the peptidoglycan glycosyltransferase enzyme MurG.
ACS Chem Biol
; 8(11): 2442-51, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23957438
20.
Comparison of lipoprotein separation and lipid analysis methodologies for human and cynomolgus monkey plasma samples.
J Cardiovasc Transl Res
; 5(1): 75-83, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22194019