Detalhe da pesquisa
1.
The Adaptive Potential of the Middle Domain of Yeast Hsp90.
Mol Biol Evol
; 38(2): 368-379, 2021 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32871012
2.
Pervasive contingency and entrenchment in a billion years of Hsp90 evolution.
Proc Natl Acad Sci U S A
; 115(17): 4453-4458, 2018 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29626131
3.
Dominant negative mutations in yeast Hsp90 reveal triage decision mechanism targeting client proteins for degradation.
bioRxiv
; 2024 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38260708
4.
Characterising the blood-stage antimalarial activity of pyronaridine in healthy volunteers experimentally infected with Plasmodium falciparum.
Int J Antimicrob Agents
; 64(1): 107196, 2024 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-38734217
5.
Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance.
ACS Infect Dis
; 10(4): 1174-1184, 2024 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38472113
6.
Mutational fitness landscape and drug resistance.
Curr Opin Struct Biol
; 78: 102525, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36621152
7.
A complete allosteric map of a GTPase switch in its native cellular network.
Cell Syst
; 14(3): 237-246.e7, 2023 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36801015
8.
Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease.
ACS Infect Dis
; 9(7): 1372-1386, 2023 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37390404
9.
Community-based management of a five-arm randomised clinical trial in COVID-19 outpatients in South Africa: challenges and opportunities.
Trials
; 24(1): 635, 2023 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37794489
10.
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms.
Elife
; 112022 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35723575
11.
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.
Nat Commun
; 13(1): 3556, 2022 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35729165
12.
Safety, Tolerability, and Parasite Clearance Kinetics in Controlled Human Malaria Infection after Direct Venous Inoculation of Plasmodium falciparum Sporozoites: A Model for Evaluating New Blood-Stage Antimalarial Drugs.
Am J Trop Med Hyg
; 107(4): 804-814, 2022 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36037868
13.
Analyses of HIV proteases variants at the threshold of viability reveals relationships between processing efficiency and fitness.
Virus Evol
; 7(2): veab103, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-35299788
14.
Versatile modes of peptide recognition by the AAA+ adaptor protein SspB.
Nat Struct Mol Biol
; 12(6): 520-5, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15880122
15.
Comprehensive fitness maps of Hsp90 show widespread environmental dependence.
Elife
; 92020 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32129763
16.
Evolutionary mechanisms studied through protein fitness landscapes.
Curr Opin Struct Biol
; 48: 141-148, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29351890
17.
Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function.
Cell Rep
; 15(3): 588-598, 2016 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27068472
18.
Mechanistic Asymmetry in Hsp90 Dimers.
J Mol Biol
; 427(18): 2904-11, 2015 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25843003
19.
Viewing protein fitness landscapes through a next-gen lens.
Genetics
; 198(2): 461-71, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25316787
20.
Design principles of the proteolytic cascade governing the sigmaE-mediated envelope stress response in Escherichia coli: keys to graded, buffered, and rapid signal transduction.
Genes Dev
; 21(1): 124-36, 2007 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17210793