Detalhe da pesquisa
1.
Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable.
Bioorg Med Chem Lett
; 18(16): 4723-6, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18676144
2.
A phase I pharmacodynamic study of the effects of the cyclin-dependent kinase-inhibitor AZD5438 on cell cycle markers within the buccal mucosa, plucked scalp hairs and peripheral blood mononucleocytes of healthy male volunteers.
Cancer Chemother Pharmacol
; 60(4): 479-88, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17143601
3.
The cellular phenotype of AZ703, a novel selective imidazo[1,2-a]pyridine cyclin-dependent kinase inhibitor.
Mol Cancer Ther
; 5(3): 655-64, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16546980
4.
AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts.
Mol Cancer Ther
; 8(7): 1856-66, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19509270