Detalhe da pesquisa
1.
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.
Cell Metab
; 3(6): 403-16, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16753576
2.
Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
J Med Chem
; 50(1): 149-64, 2007 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17201418
3.
Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.
J Med Chem
; 49(13): 3770-3, 2006 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16789734
4.
Microarrayed compound screening (microARCS) to identify activators and inhibitors of AMP-activated protein kinase.
J Biomol Screen
; 9(2): 112-21, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15006134
5.
A self-contained 48-well fatty acid oxidation assay.
Assay Drug Dev Technol
; 2(1): 63-9, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15090211
6.
Bioequivalence of saxagliptin/metformin immediate release (IR) fixed-dose combination tablets and single-component saxagliptin and metformin IR tablets in healthy adult subjects.
Clin Drug Investig
; 33(5): 365-74, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23549864
7.
Influence of renal or hepatic impairment on the pharmacokinetics of saxagliptin.
Clin Pharmacokinet
; 50(4): 253-65, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21348538
8.
Discovery and SAR development of thienopyridones: a class of small molecule AMPK activators.
Bioorg Med Chem Lett
; 17(12): 3254-7, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17451949
9.
The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: polar region modifications.
Bioorg Med Chem Lett
; 17(6): 1803-7, 2007 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17234407
10.
Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.
Bioorg Med Chem Lett
; 17(2): 527-32, 2007 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17070044
11.
Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction.
Bioorg Med Chem Lett
; 16(23): 5958-62, 2006 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16996734
12.
Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome.
Bioorg Med Chem Lett
; 16(24): 6241-5, 2006 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17000111
13.
Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.
Bioorg Med Chem Lett
; 16(23): 6078-81, 2006 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16973360