Detalhe da pesquisa
1.
Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats.
Mol Pain
; 122016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27899696
2.
Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents.
J Neurosci
; 34(13): 4445-52, 2014 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24671991
3.
Mouse monoclonal antibodies to transient receptor potential ankyrin 1 act as antagonists of multiple modes of channel activation.
J Pharmacol Exp Ther
; 350(2): 223-31, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24893987
4.
Development of novel azabenzofuran TRPA1 antagonists as in vivo tools.
Bioorg Med Chem Lett
; 24(15): 3464-8, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24953819
5.
Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.
J Neurosci
; 32(6): 2086-99, 2012 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22323721
6.
Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis.
J Neurosci
; 31(5): 1721-33, 2011 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21289181
7.
Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation.
Mol Pain
; 8: 36, 2012 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22571355
8.
Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia.
J Neurosci
; 30(4): 1435-40, 2010 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-20107070
9.
The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors.
J Physiol
; 589(Pt 9): 2415-31, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21486787
10.
The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons.
J Clin Invest
; 118(2): 763-76, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18172555
11.
Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks.
Brain Res Rev
; 60(1): 267-77, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19150372
12.
Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1.
Trends Pharmacol Sci
; 29(11): 550-7, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18805596
13.
Reduced TRPM8 expression underpins reduced migraine risk and attenuated cold pain sensation in humans.
Sci Rep
; 9(1): 19655, 2019 12 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31873179
14.
Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors.
J Neurosci
; 27(28): 7459-68, 2007 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17626206
15.
The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation.
J Neurosci
; 27(13): 3366-74, 2007 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17392452
16.
Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats.
J Pharmacol Exp Ther
; 326(1): 218-29, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18420600
17.
Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists.
J Med Chem
; 51(9): 2744-57, 2008 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-18386885
18.
Effect of AMG0347, a transient receptor potential type V1 receptor antagonist, and morphine on pain behavior after plantar incision.
Anesthesiology
; 108(6): 1100-8, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18497612
19.
4-Aminopyrimidine tetrahydronaphthols: a series of novel vanilloid receptor-1 antagonists with improved solubility properties.
Bioorg Med Chem Lett
; 18(6): 1830-4, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18299195
20.
Substituted aryl pyrimidines as potent and soluble TRPV1 antagonists.
Bioorg Med Chem Lett
; 18(18): 5118-22, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18722118