Pesquisa | BVS CLAP/SMR-OPAS/OMS

1.

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.

Zheng, Xingnan; Zhai, Bo; Koivunen, Peppi; Shin, Sandra J; Lu, Gang; Liu, Jiayun; Geisen, Christoph; Chakraborty, Abhishek A; Moslehi, Javid J; Smalley, David M; Wei, Xin; Chen, Xian; Chen, Zhengming; Beres, Justine M; Zhang, Jing; Tsao, Jen Lan; Brenner, Mitchell C; Zhang, Yuqing; Fan, Cheng; DePinho, Ronald A; Paik, Jihye; Gygi, Steven P; Kaelin, William G; Zhang, Qing.

Genes Dev ; 28(13): 1429-44, 2014 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-24990963

2.

Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.

Zhang, Cuiyan; Li, Xiaotong; Adelmant, Guillaume; Dobbins, Jessica; Geisen, Christoph; Oser, Matthew G; Wucherpfenning, Kai W; Marto, Jarrod A; Kaelin, William G.

Proc Natl Acad Sci U S A ; 112(50): 15372-7, 2015 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-26631746

3.

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.

Lin, Wenchu; Cao, Jian; Liu, Jiayun; Beshiri, Michael L; Fujiwara, Yuko; Francis, Joshua; Cherniack, Andrew D; Geisen, Christoph; Blair, Lauren P; Zou, Mike R; Shen, Xiaohua; Kawamori, Dan; Liu, Zongzhi; Grisanzio, Chiara; Watanabe, Hideo; Minamishima, Yoji Andrew; Zhang, Qing; Kulkarni, Rohit N; Signoretti, Sabina; Rodig, Scott J; Bronson, Roderick T; Orkin, Stuart H; Tuck, David P; Benevolenskaya, Elizaveta V; Meyerson, Matthew; Kaelin, William G; Yan, Qin.

Proc Natl Acad Sci U S A ; 108(33): 13379-86, 2011 Aug 16.

Artigo em Inglês | MEDLINE | ID: mdl-21788502

4.

Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen.

Bommi-Reddy, Archana; Almeciga, Ingrid; Sawyer, Jacqueline; Geisen, Christoph; Li, Wenliang; Harlow, Ed; Kaelin, William G; Grueneberg, Dorre A.

Proc Natl Acad Sci U S A ; 105(43): 16484-9, 2008 Oct 28.

Artigo em Inglês | MEDLINE | ID: mdl-18948595

5.

Loss of p27(Kip1) cooperates with cyclin E in T-cell lymphomagenesis.

Geisen, Christoph; Karsunky, Holger; Yücel, Raif; Möröy, Tarik.

Oncogene ; 22(11): 1724-9, 2003 Mar 20.

Artigo em Inglês | MEDLINE | ID: mdl-12642875

6.

Cyclin E.

Möröy, Tarik; Geisen, Christoph.

Int J Biochem Cell Biol ; 36(8): 1424-39, 2004 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-15147722

7.

Yaf2 inhibits Myc biological function.

Mädge, Britta; Geisen, Christoph; Möröy, Tarik; Schwab, Manfred.

Cancer Lett ; 193(2): 171-6, 2003 Apr 25.

Artigo em Inglês | MEDLINE | ID: mdl-12706874

8.

Comparison of three dsDNA-ELISAs with regard to their efficiency in the diagnosis of systemic lupus erythematosus.

Linnemann, Markus; Geisen, Christoph; Menn, Sabine; Herzberg, Christian; Dinser, Robert; Wielckens, Klaus.

Clin Lab ; 48(1-2): 45-52, 2002.

Artigo em Inglês | MEDLINE | ID: mdl-11833675

9.

DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation.

Horn, Moritz; Geisen, Christoph; Cermak, Lukas; Becker, Ben; Nakamura, Shuhei; Klein, Corinna; Pagano, Michele; Antebi, Adam.

Dev Cell ; 28(6): 697-710, 2014 Mar 31.

Artigo em Inglês | MEDLINE | ID: mdl-24613396

10.

Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase.

Zhang, Qing; Gu, Jinming; Li, Lianjie; Liu, Jiayun; Luo, Biao; Cheung, Hiu-Wing; Boehm, Jesse S; Ni, Min; Geisen, Christoph; Root, David E; Polyak, Kornelia; Brown, Myles; Richardson, Andrea L; Hahn, William C; Kaelin, William G; Bommi-Reddy, Archana.

Cancer Cell ; 16(5): 413-24, 2009 Nov 06.

Artigo em Inglês | MEDLINE | ID: mdl-19878873

11.

A protective role for the human SMG-1 kinase against tumor necrosis factor-alpha-induced apoptosis.

Oliveira, Vasco; Romanow, William J; Geisen, Christoph; Otterness, Diane M; Mercurio, Frank; Wang, Hong Gang; Dalton, William S; Abraham, Robert T.

J Biol Chem ; 283(19): 13174-84, 2008 May 09.

Artigo em Inglês | MEDLINE | ID: mdl-18326048

12.

The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein.

Geisen, Christoph; Moroy, Tarik.

J Biol Chem ; 277(42): 39909-18, 2002 Oct 18.

Artigo em Inglês | MEDLINE | ID: mdl-12149264

13.

Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling.

Tsao, Cheng-Chung; Geisen, Christoph; Abraham, Robert T.

EMBO J ; 23(23): 4660-9, 2004 Nov 24.

Artigo em Inglês | MEDLINE | ID: mdl-15538388

14.

Identification of a novel Krüppel-associated box domain protein, Krim-1, that interacts with c-Myc and inhibits its oncogenic activity.

Hennemann, Hanjo; Vassen, Lothar; Geisen, Christoph; Eilers, Martin; Möröy, Tarik.

J Biol Chem ; 278(31): 28799-811, 2003 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-12748187

15.

New indene-derivatives with anti-proliferative properties.

Karaguni, Ioanna-Maria; Glüsenkamp, Karl-Heinz; Langerak, Anette; Geisen, Christoph; Ullrich, Volker; Winde, Günther; Möröy, Tarik; Müller, Oliver.

Bioorg Med Chem Lett ; 12(4): 709-13, 2002 Feb 25.

Artigo em Inglês | MEDLINE | ID: mdl-11844707

16.

The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.

Brumbaugh, Kathryn M; Otterness, Diane M; Geisen, Christoph; Oliveira, Vasco; Brognard, John; Li, Xiaojie; Lejeune, Fabrice; Tibbetts, Randal S; Maquat, Lynne E; Abraham, Robert T.

Mol Cell ; 14(5): 585-98, 2004 Jun 04.

Artigo em Inglês | MEDLINE | ID: mdl-15175154

BVS CLAP/SMR-OPAS/OMS

Centro Latino Americano de Perinatologia, Saúde da Mulher e Reprodutiva

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