Detalhe da pesquisa
1.
Design and synthesis of novel proline based factor XIa selective inhibitors as leads for potential new anticoagulants.
Bioorg Med Chem Lett
; 30(16): 127072, 2020 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32340773
2.
Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects.
Bioorg Med Chem Lett
; 26(23): 5724-5728, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27815121
3.
Rapid development of two factor IXa inhibitors from hit to lead.
Bioorg Med Chem Lett
; 25(11): 2321-5, 2015 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25937013
4.
Development of a novel class of potent and selective FIXa inhibitors.
Bioorg Med Chem Lett
; 25(21): 4945-4949, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25978966
5.
Development of a novel tricyclic class of potent and selective FIXa inhibitors.
Bioorg Med Chem Lett
; 25(22): 5437-43, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26318999
6.
Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors.
Bioorg Med Chem Lett
; 23(23): 6228-33, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24157366
7.
The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors.
Bioorg Med Chem Lett
; 22(1): 658-65, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22079761
8.
Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors.
Bioorg Med Chem Lett
; 22(4): 1550-6, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22264488
9.
A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation.
Bioorg Med Chem Lett
; 22(8): 2811-7, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22444683
10.
A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes.
Bioorg Med Chem Lett
; 22(8): 2818-22, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22444685
11.
Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine.
Bioorg Med Chem Lett
; 22(4): 1774-8, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22248857
12.
Corrigendum to "Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects" [Bioorg. Med. Chem. Lett. 26 (2016) 5724-5728].
Bioorg Med Chem Lett
; 27(5): 1333, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28169160
13.
Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors.
Bioorg Med Chem Lett
; 21(5): 1299-305, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21315588
14.
Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase.
Proteomics
; 10(15): 2882-6, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20517885
15.
Enzymatic preparation of high-specific-activity beta-D-[6,6'-3H]fructose-2,6-bisphosphate: Application to a sensitive assay for fructose-2,6-bisphosphatase.
Anal Biochem
; 406(2): 97-104, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20541516
16.
Expression, purification and crystallization of human prolylcarboxypeptidase.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 66(Pt 6): 702-5, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20516604
17.
Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization.
J Med Chem
; 63(21): 12156-12170, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32633947
18.
Preclinical and translational evaluation of coagulation factor IXa as a novel therapeutic target.
Pharmacol Res Perspect
; 4(1): e00207, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26977298
19.
Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.
J Med Chem
; 59(5): 1818-29, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26871940
20.
Amino acid substitution of arginine 80 in 17beta-hydroxysteroid dehydrogenase type 3 and its effect on NADPH cofactor binding and oxidation/reduction kinetics.
Biochim Biophys Acta
; 1601(1): 29-37, 2002 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-12429500