Detalhe da pesquisa
1.
The evaluation and management of drug effects on cardiac conduction (PR and QRS intervals) in clinical development.
Am Heart J
; 165(4): 489-500, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23537964
2.
Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute.
J Pharmacol Toxicol Methods
; 121: 107265, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36997076
3.
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As.
J Pharmacol Toxicol Methods
; 123: 107270, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37164235
4.
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins.
J Pharmacol Toxicol Methods
; 109: 107066, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33838254
5.
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins.
J Pharmacol Toxicol Methods
; 111: 107109, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34416395
6.
Gaining Efficiency in Clinical Trials With Cardiac Biomarkers: JACC Review Topic of the Week.
J Am Coll Cardiol
; 77(15): 1922-1933, 2021 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33858628
7.
Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.
Clin Pharmacol Ther
; 109(2): 310-318, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32866317
8.
Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs.
J Pharmacol Toxicol Methods
; 103: 106871, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32360993
9.
Preclinical Torsades-de-Pointes screens: advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk.
Pharmacol Ther
; 119(2): 199-209, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18621077
10.
Effect of the multitargeted receptor tyrosine kinase inhibitor, ABT-869 [N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea], on blood pressure in conscious rats and mice: reversal with antihypertensive agents and effect on tumor growth inhibition.
J Pharmacol Exp Ther
; 329(3): 928-37, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19255283
11.
ETA receptor blockade with atrasentan prevents hypertension with the multitargeted tyrosine kinase inhibitor ABT-869 in telemetry-instrumented rats.
J Cardiovasc Pharmacol
; 53(2): 173-8, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19188829
12.
Cardiovascular effects of torcetrapib in conscious and pentobarbital-anesthetized dogs.
J Cardiovasc Pharmacol
; 54(6): 543-51, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19770671
13.
Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms.
J Pharmacol Toxicol Methods
; 99: 106612, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31319140
14.
Introduction to biological complexity as a missing link in drug discovery.
Expert Opin Drug Discov
; 13(8): 753-763, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29871539
15.
Can non-clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium.
Br J Pharmacol
; 175(4): 606-617, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29181850
16.
Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension.
J Med Chem
; 50(13): 2990-3003, 2007 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17523610
17.
1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.
J Med Chem
; 50(9): 2011-29, 2007 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17425296
18.
The effects of plasma proteins on delayed repolarization in vitro with cisapride, risperidone, and D, L-sotalol.
J Pharmacol Toxicol Methods
; 56(1): 11-7, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17350293
19.
Predictive, non-GLP models of secondary pharmacodynamics: putting the best compounds forward.
Curr Opin Chem Biol
; 9(4): 392-9, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15950522
20.
Block of hERG channel by ziprasidone: biophysical properties and molecular determinants.
Biochem Pharmacol
; 71(3): 278-86, 2006 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-16325148