Detalhe da pesquisa
1.
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.
Nature
; 586(7827): 113-119, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32707573
2.
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.
Nature
; 537(7619): 229-233, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27501246
3.
Targeting Plasmodium PI(4)K to eliminate malaria.
Nature
; 504(7479): 248-253, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24284631
4.
Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease.
PLoS Pathog
; 11(7): e1005058, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26186534
5.
Fitness costs of rifampicin resistance in Mycobacterium tuberculosis are amplified under conditions of nutrient starvation and compensated by mutation in the ß' subunit of RNA polymerase.
Mol Microbiol
; 91(6): 1106-19, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24417450
6.
KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro.
Antimicrob Agents Chemother
; 58(3): 1586-95, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24366744
7.
KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission.
Antimicrob Agents Chemother
; 58(9): 5060-7, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24913172
8.
A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration.
Proc Natl Acad Sci U S A
; 106(7): 2097-103, 2009 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-19196968
9.
Coresistance to isoniazid and ethionamide maps to mycothiol biosynthetic genes in Mycobacterium bovis.
Antimicrob Agents Chemother
; 55(9): 4422-3, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21709101
10.
Gene set enrichment in eQTL data identifies novel annotations and pathway regulators.
PLoS Genet
; 4(5): e1000070, 2008 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-18464898
11.
Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.
J Med Chem
; 63(19): 10773-10781, 2020 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32667203
12.
Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4.
Anal Biochem
; 392(2): 162-8, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19482004
13.
A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity.
PLoS One
; 9(10): e110226, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25329148
14.
An in vivo screen of secreted proteins identifies adiponectin as a regulator of murine cutaneous wound healing.
J Invest Dermatol
; 133(3): 812-821, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23096717
15.
Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin.
Cell Host Microbe
; 11(6): 654-63, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22704625
16.
Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds.
Mol Biochem Parasitol
; 175(1): 21-9, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20813141
17.
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.
Science
; 334(6061): 1372-7, 2011 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22096101
18.
Efficacy and immunogenicity of Mycobacterium bovis DeltaRD1 against aerosol M. bovis infection in neonatal calves.
Vaccine
; 27(8): 1201-9, 2009 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19135497
19.
Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: the NOD model of type 1 diabetes.
Genome Res
; 12(2): 232-43, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-11827943
20.
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse.
Proc Natl Acad Sci U S A
; 100(6): 3380-5, 2003 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-12612341