Detalhe da pesquisa
1.
Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited in response to inotropic interventions.
Proc Natl Acad Sci U S A
; 121(8): e2314914121, 2024 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38346202
2.
Synthetic thick filaments: A new avenue for better understanding the myosin super-relaxed state in healthy, diseased, and mavacamten-treated cardiac systems.
J Biol Chem
; 296: 100114, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33234590
3.
Omecamtiv Mecarbil Abolishes Length-Mediated Increase in Guinea Pig Cardiac Myofiber Ca2+ Sensitivity.
Biophys J
; 113(4): 880-888, 2017 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28834724
4.
Cardiomyopathy-related mutation (A30V) in mouse cardiac troponin T divergently alters the magnitude of stretch activation in α- and ß-myosin heavy chain fibers.
Am J Physiol Heart Circ Physiol
; 312(1): H141-H149, 2017 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27769999
5.
The effect of cardiomyopathy mutation (R97L) in mouse cardiac troponin T on the muscle length-mediated recruitment of crossbridges is modified divergently by α- and ß-myosin heavy chain.
Arch Biochem Biophys
; 601: 105-12, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26792537
6.
L71F mutation in rat cardiac troponin T augments crossbridge recruitment and detachment dynamics against α-myosin heavy chain, but not against ß-myosin heavy chain.
J Muscle Res Cell Motil
; 37(6): 215-223, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27975185
7.
Interplay between the effects of a Protein Kinase C phosphomimic (T204E) and a dilated cardiomyopathy mutation (K211Δ or R206W) in rat cardiac troponin T blunts the magnitude of muscle length-mediated crossbridge recruitment against the ß-myosin heavy chain background.
J Muscle Res Cell Motil
; 37(3): 83-93, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27411801
8.
The functional effect of dilated cardiomyopathy mutation (R144W) in mouse cardiac troponin T is differently affected by α- and ß-myosin heavy chain isoforms.
Am J Physiol Heart Circ Physiol
; 308(8): H884-93, 2015 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25681424
9.
Rat cardiac troponin T mutation (F72L)-mediated impact on thin filament cooperativity is divergently modulated by α- and ß-myosin heavy chain isoforms.
Am J Physiol Heart Circ Physiol
; 309(8): H1260-70, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26342069
10.
Effects of pseudo-phosphorylated rat cardiac troponin T are differently modulated by α- and ß-myosin heavy chain isoforms.
Basic Res Cardiol
; 109(6): 442, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25301196
11.
Deletion of 1-43 amino acids in cardiac myosin essential light chain blunts length dependency of Ca(2+) sensitivity and cross-bridge detachment kinetics.
Am J Physiol Heart Circ Physiol
; 304(2): H253-9, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23144314
12.
Mavacamten, a precision medicine for hypertrophic cardiomyopathy: From a motor protein to patients.
Sci Adv
; 9(30): eabo7622, 2023 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37506209
13.
Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited via inotropic effectors.
bioRxiv
; 2023 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37090664
14.
The N-terminal extension of cardiac troponin T stabilizes the blocked state of cardiac thin filament.
Biophys J
; 103(5): 940-8, 2012 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23009843
15.
Alanine or aspartic acid substitutions at serine23/24 of cardiac troponin I decrease thin filament activation, with no effect on crossbridge detachment kinetics.
Arch Biochem Biophys
; 525(1): 1-8, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22684024
16.
Two Classes of Myosin Inhibitors, Para-nitroblebbistatin and Mavacamten, Stabilize ß-Cardiac Myosin in Different Structural and Functional States.
J Mol Biol
; 433(23): 167295, 2021 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34627791
17.
Developmental increase in ß-MHC enhances sarcomere length-dependent activation in the myocardium.
J Gen Physiol
; 151(5): 635-644, 2019 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30602626
18.
Dilated Cardiomyopathy Mutation (R134W) in Mouse Cardiac Troponin T Induces Greater Contractile Deficits against α-Myosin Heavy Chain than against ß-Myosin Heavy Chain.
Front Physiol
; 7: 443, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27757084
19.
Prediction of the in vivo force-velocity relationship of slow human skeletal muscle from measurements in myofibers.
Ann Biomed Eng
; 41(8): 1767-77, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23661216
20.
The tropomyosin binding region of cardiac troponin T modulates crossbridge recruitment dynamics in rat cardiac muscle fibers.
J Mol Biol
; 425(9): 1565-81, 2013 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23357173