Detalhe da pesquisa
1.
Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC).
Bioorg Med Chem Lett
; 29(11): 1380-1385, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30952592
2.
Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety.
Bioorg Med Chem Lett
; 29(10): 1182-1186, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30926247
3.
GPR40 reduces food intake and body weight through GLP-1.
Am J Physiol Endocrinol Metab
; 313(1): E37-E47, 2017 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28292762
4.
Hypothalamic neural projections are permanently disrupted in diet-induced obese rats.
Cell Metab
; 7(2): 179-85, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18249177
5.
Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia.
J Lipid Res
; 53(1): 51-65, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22021650
6.
Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors.
Bioorg Med Chem Lett
; 22(4): 1550-6, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22264488
7.
A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation.
Bioorg Med Chem Lett
; 22(8): 2811-7, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22444683
8.
A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes.
Bioorg Med Chem Lett
; 22(8): 2818-22, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22444685
9.
The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization.
Bioorg Med Chem
; 20(9): 2845-9, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22494842
10.
Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver.
PLoS One
; 14(2): e0211568, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30811418
11.
DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates.
Cell Metab
; 27(6): 1236-1248.e6, 2018 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29706567
12.
Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety.
ACS Med Chem Lett
; 5(10): 1082-7, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25349648
13.
Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release--potential insight into mechanism of action.
Obesity (Silver Spring)
; 21(7): 1406-15, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23671037
14.
Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety.
ACS Med Chem Lett
; 4(8): 773-8, 2013 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900745
15.
Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity.
ACS Med Chem Lett
; 3(3): 252-6, 2012 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900461
16.
Maternal obesity increases hypothalamic leptin receptor expression and sensitivity in juvenile obesity-prone rats.
Am J Physiol Regul Integr Comp Physiol
; 292(5): R1782-91, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17218441
17.
Postnatal environment overrides genetic and prenatal factors influencing offspring obesity and insulin resistance.
Am J Physiol Regul Integr Comp Physiol
; 291(3): R768-78, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16614055
18.
Regulation of body weight and carcass composition by sibutramine in rats.
Obes Res
; 10(3): 173-81, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-11886940