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1.
Clin Infect Dis ; 56(8): 1067-74, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23325428

RESUMO

BACKGROUND: The epidemic of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has had a disproportionate impact on patients with human immunodeficiency virus (HIV). METHODS: We evaluated CA-MRSA colonization burden (number of colonized sites per total number sampled) among HIV-infected and HIV-negative inpatients within 72 hours of hospitalization. From March 2011 through April 2012, we obtained cultures from nasal and extranasal sites (throat, axilla, inguinal, perirectal, and chronic wound if present) and collected risk factor data. RESULTS: Of 745 patients (374 HIV-infected, 371 HIV-negative), 15.7% were colonized with CA-MRSA at any site: 20% of HIV and 11% of HIV-negative patients (relative prevalence=1.8, P=.002). HIV-infected patients had a higher prevalence of nasal, extranasal, and exclusive extranasal colonization as well as higher colonization burden. Perirectal and inguinal areas were the extranasal sites most frequently colonized, and 38.5% of colonized patients had exclusive extranasal colonization. Seventy-three percent of isolates were identified as USA300. Among HIV-infected patients, male sex, younger age, and recent incarceration were positively associated whereas Hispanic ethnicity was negatively associated with higher colonization burden. Among HIV-negative patients, temporary housing (homeless, shelter, or substance abuse center) was the only factor associated with higher colonization burden. Predictors of USA300 included HIV, younger age, illicit drug use, and male sex; all but 1 colonized individual with current or recent incarceration carried USA300. CONCLUSIONS: HIV-infected patients were more likely to have a higher CA-MRSA colonization burden and carry USA300. In certain populations, enhanced community and outpatient-based infection control strategies may be needed to prevent CA-MRSA cross-transmission and infection.


Assuntos
Portador Sadio/epidemiologia , Infecções por HIV/microbiologia , Staphylococcus aureus Resistente à Meticilina , Prisões , Infecções Estafilocócicas/epidemiologia , Adulto , Idoso , Carga Bacteriana , Portador Sadio/microbiologia , Infecções Comunitárias Adquiridas , Feminino , Infecções por HIV/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Nariz/microbiologia , Prevalência , Fatores de Risco , Infecções Estafilocócicas/microbiologia
2.
Open Forum Infect Dis ; 2(4): ofv148, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26543878

RESUMO

Community-associated methicillin-resistant Staphylococcus aureus (MRSA) has had a significant impact on human immunodeficiency virus (HIV)-infected and incarcerated individuals. We examined electronic medical surveillance data from 2006 to 2011 and observed that even in a population of currently or recently incarcerated individuals, HIV status was a significant risk factor for MRSA infections and Hispanic ethnicity was protective.

3.
Am J Health Syst Pharm ; 67(8): 622-8, 2010 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-20360589

RESUMO

PURPOSE: The development and implementation of an extended-infusion piperacillin-tazobactam program at an urban teaching hospital are described. SUMMARY: A multidisciplinary team was formed to address the feasibility of converting from the standard 30-minute infusion to an extended infusion of piperacillin- tazobactam. Before hospitalwide implementation, feasibility studies were performed in a subset of patients to identify potential barriers to program implementation. On the day of hospitalwide conversion, the orderables for piperacillin-tazobactam were reprogrammed in the computerized prescriber-order-entry system to allow separate options for the 30-minute infusion (for pediatric patients) and the extended-infusion regimen. After selecting the orderable for the extended-infusion regimen, an electronic message appeared to remind prescribers of the rationale for this change and recommended indications for piperacillin-tazobactam. Program success was prospectively evaluated on 11 weekdays after hospitalwide conversion for all 96 adult inpatients receiving piperacillin-tazobactam. Of the 194 piperacillin-tazobactam doses observed, 90% were appropriate, with compliance increasing to 100% by the end of the observation period. There was near-complete cessation of the every-6-hour dosage interval and a marked increase in the every-8-hour and every-12-hour dosage intervals. The number of piperacillin-tazobactam doses per 1000 patient-days significantly decreased during the postimplementation period. During the postimplementation period, pharmacy expenditures related to piperacillin-tazobactam decreased by 18% and the total number of grams of piperacillin-tazobactam purchased decreased by 24%. CONCLUSION: A hospitalwide program for the administration of extended-infusion piperacillin-tazobactam was safely and successfully implemented using a multi-disciplinary approach in an urban teaching hospital.


Assuntos
Antibacterianos/administração & dosagem , Antibacterianos/economia , Cuidados Críticos , Hospitais de Ensino , Humanos , Bombas de Infusão , Infusões Intravenosas , Erros Médicos , Equipe de Assistência ao Paciente , Ácido Penicilânico/administração & dosagem , Ácido Penicilânico/análogos & derivados , Ácido Penicilânico/economia , Serviço de Farmácia Hospitalar/organização & administração , Piperacilina/administração & dosagem , Piperacilina/economia , Combinação Piperacilina e Tazobactam , Estudos Prospectivos , Garantia da Qualidade dos Cuidados de Saúde
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