Detalhe da pesquisa
1.
Inhibition of the hERG potassium ion channel by different non-nucleoside human cytomegalovirus polymerase antiviral inhibitor series and the exploration of variations on a pyrroloquinoline core to reduce cardiotoxicity potential.
Bioorg Med Chem
; 85: 117276, 2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37037115
2.
Discovery and preclinical evaluations of GST-HG131, a novel HBV antigen inhibitor for the treatment of chronic hepatitis B infection.
Bioorg Med Chem Lett
; 75: 128977, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36089112
3.
Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent.
Bioorg Med Chem
; 28(12): 115551, 2020 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32503695
4.
Preclinical evaluation of Amphihevir, a first-in-class clinical Hepatitis C virus NS4B inhibitor.
Antimicrob Agents Chemother
; 63(12)2019 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31527036
5.
Structure-activity relationship study of a series of caspase inhibitors containing γ-amino acid moiety for treatment of cholestatic liver disease.
Bioorg Med Chem Lett
; 28(10): 1874-1878, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29650287
6.
PTC725, an NS4B-Targeting Compound, Inhibits a Hepatitis C Virus Genotype 3 Replicon, as Predicted by Genome Sequence Analysis and Determined Experimentally.
Antimicrob Agents Chemother
; 60(12): 7060-7066, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27620477
7.
Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B.
Bioorg Med Chem Lett
; 26(2): 594-601, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26652483
8.
Design, synthesis, and biological evaluation of anti-EV71 agents.
Bioorg Med Chem Lett
; 26(14): 3346-3350, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27234148
9.
6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B.
Bioorg Med Chem Lett
; 25(4): 781-6, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25613678
10.
Identification of PTC725, an orally bioavailable small molecule that selectively targets the hepatitis C Virus NS4B protein.
Antimicrob Agents Chemother
; 57(7): 3250-61, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23629699
11.
Discovery of N-(4'-(indol-2-yl)phenyl)sulfonamides as novel inhibitors of HCV replication.
Bioorg Med Chem Lett
; 23(13): 3942-6, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23683596
12.
Discovery of novel HCV inhibitors: synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B.
Bioorg Med Chem Lett
; 23(13): 3947-53, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23683597
13.
High-throughput screening uncovers a compound that activates latent HIV-1 and acts cooperatively with a histone deacetylase (HDAC) inhibitor.
J Biol Chem
; 286(24): 21083-91, 2011 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-21498519
14.
Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability.
J Med Chem
; 65(4): 2905-2925, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34242027
15.
Discovery of 3,3'-Spiro[Azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection.
ACS Med Chem Lett
; 9(2): 94-97, 2018 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456794
16.
Correction to "The Discovery of 3,3'-Spiro[azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection".
ACS Med Chem Lett
; 9(4): 397, 2018 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29671838
17.
Discovery and Assessment of Atropisomers of (±)-Lesinurad.
ACS Med Chem Lett
; 8(3): 299-303, 2017 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28337320
18.
Identification of benzazole compounds that induce HIV-1 transcription.
PLoS One
; 12(6): e0179100, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28658263
19.
Discovery of Potent EV71 Capsid Inhibitors for Treatment of HFMD.
ACS Med Chem Lett
; 8(8): 841-846, 2017 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28835799
20.
Design, Synthesis, and Evaluation of Tetrahydropyrrolo[1,2-c]pyrimidines as Capsid Assembly Inhibitors for HBV Treatment.
ACS Med Chem Lett
; 8(9): 969-974, 2017 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28947946