Detalhe da pesquisa
1.
RIP3 induces apoptosis independent of pronecrotic kinase activity.
Mol Cell
; 56(4): 481-95, 2014 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25459880
2.
CCR2 receptor antagonists: optimization of biaryl sulfonamides to increase activity in whole blood.
Bioorg Med Chem Lett
; 21(24): 7291-4, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22047688
3.
Optimization of a Series of RIPK2 PROTACs.
J Med Chem
; 64(17): 12978-13003, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34432979
4.
Understanding Pharmacokinetic Disconnect in Preclinical Species for 4-Aminoquinolines: Consequences of Low Permeability and High P-glycoprotein Efflux Ratio on Rat and Dog Oral Pharmacokinetics.
J Pharm Sci
; 109(10): 3160-3171, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32565354
5.
Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2.
Commun Biol
; 3(1): 140, 2020 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32198438
6.
Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ACS Med Chem Lett
; 11(6): 1353, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551024
7.
Enantioselective total synthesis of brevetoxin A: unified strategy for the B, E, G, and J subunits.
Chemistry
; 15(36): 9223-34, 2009 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19650091
8.
Silylene-mediated ring contraction of homoallylic ethers to form allylic silanes.
J Org Chem
; 74(18): 7180-2, 2009 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19681592
9.
Silylene oxonium ylides: di-tert-butylsilylene insertion into C-O bonds.
Tetrahedron
; 65(28): 5608-5613, 2009 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20631913
10.
Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.
ACS Med Chem Lett
; 10(11): 1518-1523, 2019 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31749904
11.
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
J Med Chem
; 62(14): 6482-6494, 2019 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31265286
12.
Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ACS Med Chem Lett
; 9(10): 1039-1044, 2018 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30344914
13.
The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.
J Med Chem
; 59(10): 4867-80, 2016 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27109867
14.
Identification of selective small molecule inhibitors of the nucleotide-binding oligomerization domain 1 (NOD1) signaling pathway.
PLoS One
; 9(5): e96737, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24806487
15.
Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway.
PLoS One
; 8(8): e69619, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23936340
16.
Total synthesis of brevetoxin A.
Org Lett
; 11(2): 489-92, 2009 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19099481
17.
Ion-molecule chemistry within boron tribromide clusters: experiment and theory.
J Phys Chem A
; 111(12): 2266-75, 2007 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-17388306