Detalhe da pesquisa
1.
Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement.
J Leukoc Biol
; 78(2): 471-80, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15894589
2.
Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia.
J Med Chem
; 59(24): 11039-11049, 2016 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28002958
3.
Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3.
J Med Chem
; 48(20): 6169-73, 2005 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16190743
4.
Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.
ACS Med Chem Lett
; 6(8): 861-5, 2015 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26288685
5.
Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.
ACS Med Chem Lett
; 6(5): 573-8, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26005536
6.
A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.
J Med Chem
; 47(27): 6662-5, 2004 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15615513
7.
Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain.
ACS Med Chem Lett
; 5(6): 717-21, 2014 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24944750
8.
Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase.
ACS Med Chem Lett
; 4(6): 509-13, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900701
9.
1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.
J Med Chem
; 55(7): 2945-59, 2012 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22364528
10.
SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P1) with enhanced pharmacokinetic properties.
Bioorg Med Chem Lett
; 17(3): 828-31, 2007 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17092714
11.
2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.
Bioorg Med Chem Lett
; 16(13): 3564-8, 2006 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16621543
12.
Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor.
Bioorg Med Chem Lett
; 16(14): 3684-7, 2006 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16682185
13.
2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists.
Bioorg Med Chem Lett
; 16(11): 2905-8, 2006 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16580205
14.
Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes.
Bioorg Med Chem Lett
; 16(14): 3679-83, 2006 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16697189
15.
Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720.
Bioorg Med Chem
; 12(18): 4803-7, 2004 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15336258
16.
Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.
J Biol Chem
; 279(50): 52487-92, 2004 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-15459201
17.
The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.
Bioorg Med Chem Lett
; 14(13): 3495-9, 2004 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-15177460
18.
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.
Science
; 296(5566): 346-9, 2002 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-11923495
19.
Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.
Bioorg Med Chem Lett
; 14(12): 3351-5, 2004 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15149705
20.
Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors.
Bioorg Med Chem Lett
; 14(19): 4861-6, 2004 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-15341940