Detalhe da pesquisa
1.
ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1.
Mol Cell
; 82(13): 2443-2457.e7, 2022 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35613620
2.
Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation.
N Engl J Med
; 389(8): 710-721, 2023 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37611121
3.
Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization.
Proc Natl Acad Sci U S A
; 120(5): e2208960120, 2023 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36689660
4.
Pragmatic nationwide master observational trial based on genomic alterations in advanced solid tumors: KOrean Precision Medicine Networking Group Study of MOlecular profiling guided therapy based on genomic alterations in advanced Solid tumors (KOSMOS)-II study protocol KCSG AL-22-09.
BMC Cancer
; 24(1): 574, 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38724991
5.
Mutational evolution after chemotherapy-progression in metastatic colorectal cancer revealed by circulating tumor DNA analysis.
Int J Cancer
; 153(3): 571-583, 2023 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37194418
6.
Personalised circulating tumour DNA assay with large-scale mutation coverage for sensitive minimal residual disease detection in colorectal cancer.
Br J Cancer
; 129(2): 374-381, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37280413
7.
Total neoadjuvant therapy with short-course radiotherapy Versus long-course neoadjuvant chemoradiotherapy in Locally Advanced Rectal cancer, Korean trial (TV-LARK trial): study protocol of a multicentre randomized controlled trial.
BMC Cancer
; 23(1): 734, 2023 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37553666
8.
Prognostic Impact of Extramural Lymphatic, Vascular, and Perineural Invasion in Stage II Colon Cancer: A Comparison With Intramural Invasion.
Dis Colon Rectum
; 66(3): 366-373, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35333785
9.
Standard versus longer interval of radical resection after neoadjuvant chemoradiotherapy in locally advanced rectal cancer: A 20-year single-center experience & propensity-score matching.
J Surg Oncol
; 127(1): 119-131, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36169163
10.
Sotorasib for previously treated colorectal cancers with KRASG12C mutation (CodeBreaK100): a prespecified analysis of a single-arm, phase 2 trial.
Lancet Oncol
; 23(1): 115-124, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34919824
11.
Dynamic changes in longitudinal circulating tumour DNA profile during metastatic colorectal cancer treatment.
Br J Cancer
; 127(5): 898-907, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35643791
12.
Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer.
J Biol Chem
; 295(4): 1105-1119, 2020 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31836666
13.
Impact of UGT1A1 genotype on the efficacy and safety of irinotecan-based chemotherapy in metastatic colorectal cancer.
Cancer Sci
; 112(11): 4669-4678, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34327766
14.
Circulating Tumor Marker Isolation with the Chemically Stable and Instantly Degradable (CSID) Hydrogel ImmunoSpheres.
Anal Chem
; 93(2): 1100-1109, 2021 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33337853
15.
Phenotype-based single cell sequencing identifies diverse genetic subclones in CD133 positive cancer stem cells.
Biochem Biophys Res Commun
; 558: 209-215, 2021 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32958251
16.
A phase 1 dose-escalation and dose-expansion study to assess the safety and efficacy of CKD-516, a novel vascular disrupting agent, in combination with Irinotecan in patients with previously treated metastatic colorectal cancer.
Invest New Drugs
; 39(5): 1335-1347, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33829355
17.
Activation of WNT/ß-catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations.
Int J Cancer
; 144(2): 389-401, 2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29978469
18.
p53 expression status is associated with cancer-specific survival in stage III and high-risk stage II colorectal cancer patients treated with oxaliplatin-based adjuvant chemotherapy.
Br J Cancer
; 120(8): 797-805, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30894685
19.
Immune recurrence score using 7 immunoregulatory protein expressions can predict recurrence in stage I-III breast cancer patients.
Br J Cancer
; 121(3): 230-236, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31292534
20.
A First-in-Human Phase I Study of GC1118, a Novel Anti-Epidermal Growth Factor Receptor Antibody, in Patients with Advanced Solid Tumors.
Oncologist
; 24(8): 1037-e636, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31164456