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Sodium dual-ion batteries (Na-DIBs) have attracted increasing attention due to their high operative voltages and low-cost raw materials. However, the practical applications of Na-DIBs are still hindered by the issues, such as low capacity and poor Coulombic efficiency, which is highly correlated with the compatibility between electrode and electrolyte but rarely investigated. Herein, fluoroethylene carbonate (FEC) is introduced into the electrolyte to regulate cation/anion solvation structure and the stability of cathode/anode-electrolyte interphase of Na-DIBs. The FEC modulates the environment of PF6 - solvation sheath and facilitates the interaction of PF6 - on graphite. In addition, the NaF-rich interphase caused by the preferential decomposition of FEC effectively inhibits side reactions and pulverization of anodes with the electrolyte. Consequently, Sb||graphite full cells in FEC-containing electrolyte achieve an improved capacity, cycling stability and Coulombic efficiency. This work elucidates the underlying mechanism of bifunctional FEC and provides an alternative strategy of building high-performance dual ion batteries.
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OBJECTIVE: To explore the diagnosis and treatment of focal nodular hyperplasia (FNH) of liver. METHODS: The clinical data were retrospectively analyzed for 26 cases with confirmed FNH of liver from January 2006 to July 2011. Enhanced computed tomography and magnetic resonance imaging were performed. RESULTS: Among them, 22 cases underwent surgical resection, including left hemihepatectomy (n = 4), left lateral lobe hepatectomy (n = 5) and partial hepatectomy (n = 13). The pathological diagnosis was FNH. Most tumors were of soft texture. The gross surface was brown or yellow-brown in color. Central scar and radiating fibrous septas were spotted in some cases. There was no recurrence during a follow-up period of 4 months to 5 years. Serial observations were conducted for 4 cases with a follow-up period of 2 - 4 years. No growth was observed. CONCLUSIONS: Enhanced CT and MRI are important diagnostic tools. The confirmed cases may be followed up. Surgical resection is effective with an excellent prognosis.
Assuntos
Hiperplasia Nodular Focal do Fígado/diagnóstico , Hiperplasia Nodular Focal do Fígado/cirurgia , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos RetrospectivosRESUMO
OBJECTIVE: MicroRNAs (miRNAs) plays an important role in the development of malignant carcinoma. The small peptide intermedin (IMD) can promote hepatic carcinoma cell proliferation. The aim of the present study is to examine the effect of miR-155 on IMD-stimulated hepatic carcinoma cell proliferation. METHODS: Proliferation of hepatic carcinoma SMMC7721 cells was detected by CCK-8, expression of proliferating cell nuclear antigen (PCNA) and miR-155 was detected by real-time PCR. RESULTS: We found that IMD promotes the proliferation of SMMC7721 cells in a time and dose-dependent manner. IMD can upregulate the expression of miR-155, and blocking of miR-155 can inhibit the IMD-induced SMMC7721 cell proliferation to some extent. CONCLUSION: This study demonstrated that IMD can promote the proliferation of human hepatic carcinoma cell line SMMC7721 cells through upregulation of miR-155. This study may contribute to hepatic cancer prevention and therapy.
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A novel strategy is proposed for the increase of specific surface area (SSA) of porous carbon sphere (PCS) by oxidation and activation. 2-keto-l-gulonic acid mother liquor (GAML) as a high-pollution waste has a relatively high value of reutilization. For its high value-added utilization, GAML is used as the precursor for preparation of PCS as carbon-based electrode materials for electric double-layer capacitor. PCS is prepared by hydrothermal carbonization, carbonization and KOH activation, and Fe(NO3)3 9H2O is used as an oxidizing agent during carbonization. The as-prepared PCS has excellent porosity and high SSA of 2478â¯m2â¯g-1. Meanwhile, the pore structure of PCS can be controlled by the adjustment of carbonization parameters (carbonization temperature and the loading of Fe(NO3)3 9H2O). Besides, the SSA and specific capacitance of PCS can be increased remarkably when Fe(NO3)3 9H2O is added in carbonization. The specific capacitance of PCS can reach 303.7â¯Fâ¯g-1 at 40â¯mAâ¯g-1. PCSs as electrode material have superior electrochemical stability. After 8000 cycles, the capacitance retention is 98.3% at 2â¯Aâ¯g-1. The electric double-layer capacitance of PCS is improved when CS is carbonized with Fe(NO3)3 9H2O, and the economic and environmental benefits are achieved by the effective recycle of GAML.
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The proliferative activity of hepatic carcinoma cells is directly associated with tumorigenesis, tumor development, metastasis and invasion. A variety of cytokines and peptides serve important roles in the development of hepatic carcinoma. The aim of the present study was to examine the effect of intermedin (IMD) on hepatic carcinoma cell proliferation and its mechanism of action. HepG2 hepatic carcinoma cell lines were treated with human recombinant IMD1-53 and its receptor antagonist IMD17-47. Cell proliferation was detected using a Cell Counting kit-8. The activation of the classical Wnt signaling pathway was demonstrated by the ratio of TOPflash:FOPflash luciferase activity. The expression of c-Myc and cyclin D1 downstream of the Wnt signaling pathway were detected using reverse transcription-quantitative polymerase chain reaction analysis. It was demonstrated that IMD may promote the proliferation of HepG2 cells in a time-dependent manner, and that the IMD receptor antagonist IMD17-47 could eliminate this promotion. IMD may activate classical Wnt signaling pathway transcriptional activity and the mRNA levels of certain downstream target genes. Furthermore, blocking of the Wnt signaling pathway may inhibit IMD-induced HepG2 cell proliferation to a certain extent. IMD may promote hepatic carcinoma cell proliferation by binding with receptor antagonist IMD17-47 and activating the Wnt signaling cascade, thus providing a novel avenue for the treatment of hepatic carcinoma.
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In order to analyze characteristic CT signs in the solid pseudopapillary tumor of the pancreas, a retrospective analysis was conducted on 49 patients with pseudopapillary tumor of the pancreas who where treated in Liaoning Cancer Hospital. All of the patients were confirmed by pathology, CT signs were analyzed and a pathology contrast was conducted. Furthermore, all cases had single lesions; 7 cases in the pancreatic head, 23 cases in the pancreatic body, 15 cases in the pancreatic body-tail and 4 cases in the pancreatic tail. The boundaries of the lesions were clear and the tumors, which may outline the pancreas, were composed of solid and polycystic parts. In addition, calcifications could be observed in the lesions and CT results revealed varying degrees of contrast enhancement of the solid components in the arterial phase, as well as a gradual contrast enhancement in the venous and delayed phase. Enhancement of capsule could be observed, and the enhancement region was observed in the solid part, no enhancement in cystic part.. In conclusion, CT manifestations of solid pseudopapillary tumors of the pancreas are specific, which is helpful to the diagnosis.