Detalhe da pesquisa
1.
Uncovering new families and folds in the natural protein universe.
Nature
; 622(7983): 646-653, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37704037
2.
(p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains.
Mol Cell
; 81(16): 3310-3322.e6, 2021 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34416138
3.
Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP.
Mol Cell
; 81(1): 115-126.e7, 2021 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33259810
4.
RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis.
Mol Cell
; 81(15): 3160-3170.e9, 2021 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34174184
5.
Direct activation of a bacterial innate immune system by a viral capsid protein.
Nature
; 612(7938): 132-140, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36385533
6.
Mechanisms of neutralization of toxSAS from toxin-antitoxin modules.
Nat Chem Biol
; 2024 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38834893
7.
A role for the S4-domain containing protein YlmH in ribosome-associated quality control in Bacillus subtilis.
Nucleic Acids Res
; 2024 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38811035
8.
The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin-antitoxin and related phage defense systems.
Proc Natl Acad Sci U S A
; 120(33): e2305393120, 2023 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37556498
9.
Structure of SpoT reveals evolutionary tuning of catalysis via conformational constraint.
Nat Chem Biol
; 19(3): 334-345, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36470996
10.
Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR.
Nucleic Acids Res
; 51(9): 4536-4554, 2023 05 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36951104
11.
A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains.
Proc Natl Acad Sci U S A
; 119(6)2022 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35121656
12.
Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci.
Nucleic Acids Res
; 50(4): 2128-2142, 2022 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35137182
13.
Expression of Bacillus subtilis ABCF antibiotic resistance factor VmlR is regulated by RNA polymerase pausing, transcription attenuation, translation attenuation and (p)ppGpp.
Nucleic Acids Res
; 50(11): 6174-6189, 2022 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35699226
14.
Structural basis for HflXr-mediated antibiotic resistance in Listeria monocytogenes.
Nucleic Acids Res
; 50(19): 11285-11300, 2022 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36300626
15.
Photorhabdus antibacterial Rhs polymorphic toxin inhibits translation through ADP-ribosylation of 23S ribosomal RNA.
Nucleic Acids Res
; 49(14): 8384-8395, 2021 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34255843
16.
Ribosome association primes the stringent factor Rel for tRNA-dependent locking in the A-site and activation of (p)ppGpp synthesis.
Nucleic Acids Res
; 49(1): 444-457, 2021 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33330919
17.
RqcH and RqcP catalyze processive poly-alanine synthesis in a reconstituted ribosome-associated quality control system.
Nucleic Acids Res
; 49(14): 8355-8369, 2021 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34255840
18.
A widespread toxin-antitoxin system exploiting growth control via alarmone signaling.
Proc Natl Acad Sci U S A
; 117(19): 10500-10510, 2020 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32345719
19.
A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes.
Nat Chem Biol
; 16(8): 834-840, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32393900
20.
A role for the Saccharomyces cerevisiae ABCF protein New1 in translation termination/recycling.
Nucleic Acids Res
; 47(16): 8807-8820, 2019 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31299085