Detalhe da pesquisa
1.
Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus.
Proc Natl Acad Sci U S A
; 121(2): e2314101120, 2024 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38165935
2.
Site-Selective Palladium-catalyzed Oxidation of Unprotected Aminoglycosides and Sugar Phosphates.
Chemistry
; 30(19): e202400017, 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38284753
3.
In vitro susceptibility of Neisseria gonorrhoeae to netilmicin and etimicin in comparison to gentamicin and other aminoglycosides.
Eur J Clin Microbiol Infect Dis
; 43(5): 821-828, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38388739
4.
Synthesis of 4-O-(4-Amino-4-deoxy-ß-D-xylopyranosyl)paromomycin and 4-S-(ß-D-Xylopyranosyl)-4-deoxy-4'-thio-paromomycin and Evaluation of their Antiribosomal and Antibacterial Activity.
Tetrahedron
; 1352023 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37035443
5.
Optimization of the antimicrobial peptide Bac7 by deep mutational scanning.
BMC Biol
; 20(1): 114, 2022 05 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35578204
6.
Apramycin Overcomes the Inherent Lack of Antimicrobial Bactericidal Activity in Mycobacterium abscessus.
Antimicrob Agents Chemother
; 66(2): e0151021, 2022 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34930031
7.
Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose.
J Antimicrob Chemother
; 77(10): 2718-2728, 2022 09 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-35849148
8.
Short Synthesis of (+)-Actinobolin: Simple Entry to Complex Small-Molecule Inhibitors of Protein Synthesis.
Angew Chem Int Ed Engl
; 61(17): e202116520, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35167723
9.
Antimicrobial susceptibility patterns of respiratory Gram-negative bacterial isolates from COVID-19 patients in Switzerland.
Ann Clin Microbiol Antimicrob
; 20(1): 64, 2021 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34493302
10.
Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant.
J Am Chem Soc
; 142(1): 530-544, 2020 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31790244
11.
Predictive Analysis of the Side Chain Conformation of the Higher Carbon Sugars: Application to the Preorganization of the Aminoglycoside Ring 1 Side Chain for Binding to the Bacterial Ribosomal Decoding A Site.
J Org Chem
; 85(24): 16043-16059, 2020 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32902280
12.
Epidemiologic, Phenotypic, and Structural Characterization of Aminoglycoside-Resistance Gene aac(3)-IV.
Int J Mol Sci
; 21(17)2020 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32854436
13.
Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens.
J Am Chem Soc
; 141(12): 5051-5061, 2019 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30793894
14.
In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii.
J Antimicrob Chemother
; 74(4): 944-952, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30629184
15.
Structure-Based Design and Synthesis of Apramycin-Paromomycin Analogues: Importance of the Configuration at the 6'-Position and Differences between the 6'-Amino and Hydroxy Series.
J Am Chem Soc
; 139(41): 14611-14619, 2017 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28892368
16.
Experimental Determination of the pKa Values of Clinically Relevant Aminoglycoside Antibiotics: Toward Establishing pKa-Activity Relationships.
ACS Omega
; 9(5): 5876-5887, 2024 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38343924
17.
Phenotypic and genotypic characterization of Neisseria gonorrhoeae isolates among individuals at high risk for sexually transmitted diseases in Zurich, Switzerland.
Int J STD AIDS
; 35(6): 462-470, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38297880
18.
Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins.
J Antibiot (Tokyo)
; 2024 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38890386
19.
Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models.
Int J Antimicrob Agents
; 64(1): 107181, 2024 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-38653351
20.
Modular glycosphere assays for high-throughput functional characterization of influenza viruses.
BMC Biotechnol
; 13: 34, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23587408