1.
Boll Chim Farm
; 130(2): 55-9, 1991 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-1678611
RESUMO
Chemical modification of PLG, comprising replacement of proline or/and leucine by unnatural amino acids led to analogs with high oral efficacy. The most active analog identified in the course of our works was 1-prolyl-2-phenyl-1-2-aminobutanoylglycinamide (Doreptide). Doreptide is presently further evaluated as a new drug for the treatment of Parkinson's disease.