Detalhe da pesquisa
1.
APOE3ch alters microglial response and suppresses Aß-induced tau seeding and spread.
Cell
; 187(2): 428-445.e20, 2024 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38086389
2.
Hallmarks of neurodegenerative diseases.
Cell
; 186(4): 693-714, 2023 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36803602
3.
TREM2 drives microglia response to amyloid-ß via SYK-dependent and -independent pathways.
Cell
; 185(22): 4153-4169.e19, 2022 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36306735
4.
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.
Cell
; 185(13): 2213-2233.e25, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35750033
5.
APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFß-mediated checkpoints.
Nat Immunol
; 24(11): 1839-1853, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37749326
6.
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.
Cell
; 179(2): 312-339, 2019 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31564456
7.
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.
Cell
; 170(4): 649-663.e13, 2017 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28802038
8.
Intercellular Spread of Protein Aggregates in Neurodegenerative Disease.
Annu Rev Cell Dev Biol
; 34: 545-568, 2018 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30044648
9.
Emerging roles of innate and adaptive immunity in Alzheimer's disease.
Immunity
; 55(12): 2236-2254, 2022 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36351425
10.
Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma.
Immunity
; 55(9): 1627-1644.e7, 2022 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35977543
11.
TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.
Cell
; 160(6): 1061-71, 2015 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25728668
12.
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy.
Nature
; 615(7953): 668-677, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36890231
13.
Meningeal lymphatics affect microglia responses and anti-Aß immunotherapy.
Nature
; 593(7858): 255-260, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33911285
14.
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Immunity
; 47(3): 566-581.e9, 2017 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28930663
15.
Publisher Correction: Dietary salt promotes cognitive impairment through tau phosphorylation.
Nature
; 578(7793): E9, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31932732
16.
APOE mediated neuroinflammation and neurodegeneration in Alzheimer's disease.
Semin Immunol
; 59: 101594, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35232622
17.
Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease.
Ann Neurol
; 95(4): 625-634, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38180638
18.
Timing of Biomarker Changes in Sporadic Alzheimer's Disease in Estimated Years from Symptom Onset.
Ann Neurol
; 95(5): 951-965, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38400792
19.
Dietary salt promotes cognitive impairment through tau phosphorylation.
Nature
; 574(7780): 686-690, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31645758
20.
APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease.
Mol Ther
; 32(5): 1373-1386, 2024 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38504517