Detalhe da pesquisa
1.
Discovery of nor-seco himbacine analogs as thrombin receptor antagonists.
Bioorg Med Chem Lett
; 22(7): 2544-9, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22405832
2.
Ultrafast liquid chromatography-tandem mass spectrometry determination of donepezil in human plasma: application to a bioequivalence study.
Transl Clin Pharmacol
; 30(1): 37-48, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-35419315
3.
2-µm fused-core column ultra-high-performance liquid chromatography/tandem mass spectrometric determination of donepezil in human plasma: Application to a bioequivalence study.
J Pharm Biomed Anal
; 211: 114596, 2022 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35104737
4.
Discovery of a vorapaxar analog with increased aqueous solubility.
Bioorg Med Chem Lett
; 20(22): 6676-9, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20888225
5.
Continuous and intermittent dosing of lonafarnib potentiates the therapeutic efficacy of docetaxel on preclinical human prostate cancer models.
Int J Cancer
; 125(11): 2711-20, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19530253
6.
Ultra-performance hydrophilic interaction liquid chromatography/tandem mass spectrometry for the determination of everolimus in mouse plasma.
Rapid Commun Mass Spectrom
; 23(10): 1461-6, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19350527
7.
Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity.
J Med Chem
; 51(11): 3061-4, 2008 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18447380
8.
High-performance liquid chromatography-atmospheric pressure photoionization/tandem mass spectrometry for the detection of 17alpha-ethinylestradiol in hepatocytes.
J Chromatogr B Analyt Technol Biomed Life Sci
; 870(2): 186-91, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18603489
9.
Potential of HILIC-MS in quantitative bioanalysis of drugs and drug metabolites.
J Sep Sci
; 31(9): 1481-91, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18428187
10.
Supercritical fluid chromatography-mass spectrometry for chemical analysis.
J Sep Sci
; 31(8): 1231-7, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18366029
11.
HPLC-MS/MS in drug metabolism and pharmacokinetic screening.
Expert Opin Drug Metab Toxicol
; 4(1): 93-101, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18370861
12.
Heterotricyclic himbacine analogs as potent, orally active thrombin receptor (protease activated receptor-1) antagonists.
J Med Chem
; 50(21): 5147-60, 2007 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-17854166
13.
Metabolism-based identification of a potent thrombin receptor antagonist.
J Med Chem
; 50(1): 129-38, 2007 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17201416
14.
Mapping pharmaceuticals in tissues using MALDI imaging mass spectrometry.
J Pharmacol Toxicol Methods
; 55(2): 193-200, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-16919485
15.
A mixed-mode liquid chromatography-tandem mass spectrometric method for the determination of cytarabine in mouse plasma.
J Chromatogr B Analyt Technol Biomed Life Sci
; 854(1-2): 8-12, 2007 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17448737
16.
Ultra-performance liquid chromatography/tandem mass spectrometric determination of diastereomers of SCH 503034 in monkey plasma.
J Chromatogr B Analyt Technol Biomed Life Sci
; 852(1-2): 92-100, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17240204
17.
Comparison of fast liquid chromatography/tandem mass spectrometric methods for simultaneous determination of cladribine and clofarabine in mouse plasma.
J Pharm Biomed Anal
; 44(2): 492-7, 2007 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17368998
18.
Increasing speed and throughput when using HPLC-MS/MS systems for drug metabolism and pharmacokinetic screening.
Curr Drug Metab
; 7(5): 479-89, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16787157
19.
Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection.
J Med Chem
; 49(20): 6074-86, 2006 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17004721
20.
Fast mass spectrometry-based methodologies for pharmaceutical analyses.
Comb Chem High Throughput Screen
; 9(1): 3-8, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16454680