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A 45-year-old man, a case of acquired immunodeficiency syndrome, received a highly active antiretroviral therapy at the outpatient service for 4 years without regular follow-up. He experienced progressively blurred vision for 6 months and a cutaneous zoster on his back 3 months ago. He was diagnosed with progressive outer retinal necrosis by polymerase chain reaction-restriction fragment length polymorphism using an aqueous humor sample, which revealed an existence of varicella zoster virus. He was given a combination of systemic, intravitreal antiviral and a highly active antiretroviral therapy. Occlusive vasculitis, an unusual finding for progressive outer retinal necrosis, developed in both eyes 1 week after the secondary intravitreal injection. Unfortunately, his vision deteriorated to no light perception in both eyes within 2 weeks. Progressive outer retinal necrosis is characterized clinically as showing minimal or no inflammation in the aqueous and vitreous humors, absence of retinal vasculitis, and patches of yellowish spots located deep in the retina. Physicians should pay attention to this rare case of progressive outer retinal necrosis associated occlusive vasculitis with very poor prognosis in spite of aggressive treatment.
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Síndrome da Imunodeficiência Adquirida/complicações , Antivirais/uso terapêutico , Herpesvirus Humano 3/isolamento & purificação , Síndrome de Necrose Retiniana Aguda/tratamento farmacológico , Vasculite Retiniana/diagnóstico , Síndrome da Imunodeficiência Adquirida/tratamento farmacológico , Terapia Antirretroviral de Alta Atividade , Cegueira , Progressão da Doença , Humanos , Masculino , Pessoa de Meia-Idade , Síndrome de Necrose Retiniana Aguda/virologia , Vasculite Retiniana/tratamento farmacológico , Vasculite Retiniana/virologia , Tomografia de Coerência ÓpticaRESUMO
PURPOSE: To report the clinical characteristics of central retinal artery occlusion in eyes of proliferative diabetic retinopathy with previous vitrectomy and panretinal photocoagulation. METHODS: Retrospective case series. RESULTS: Twelve eyes in 12 patients (4 women and 8 men) with a mean age of 55.3 ± 6.2 years of age were included in this study. All patients had successful previous surgery for complications of proliferative diabetic retinopathy and complete panretinal photocoagulation performed. All patients had sudden visual deterioration and fluorescein angiography confirmed central retinal artery occlusion. Prominent cherry-red spot was noted in only two eyes. The other eyes either had less prominent or incomplete, or invisible cherry-red spots. Sequential optical coherence tomography in 7 of the 12 eyes showed increased optical reflectivity at inner retinal layer in 6 of the 7 eyes. Rubeosis iridis developed later in six eyes and neovascular glaucoma in four eyes. Vision worsening was noted in five eyes, improved in three eyes, and stable in four eyes after an averaged follow-up of 4 months. CONCLUSION: Less typical cherry-red spots, higher possibility of rubeosis despite previous complete panretinal photocoagulation, are the characteristic features of central retinal artery occlusion in patients with proliferative diabetic retinopathy with previous vitrectomy.
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Retinopatia Diabética/complicações , Retinopatia Diabética/cirurgia , Fotocoagulação a Laser , Oclusão da Artéria Retiniana/diagnóstico , Vitrectomia , Idoso , Tamponamento Interno , Feminino , Angiofluoresceinografia , Humanos , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Oclusão da Artéria Retiniana/etiologia , Estudos Retrospectivos , Tomografia de Coerência Óptica , Acuidade Visual/fisiologiaRESUMO
To report a case of stroke with internal carotid artery (ICA) occlusion and retinal artery occlusion (RAO) with multiple emboli identified by infrared images. The patient presented with acute blurred vision and slurred speech since woke up in the morning. Carotid Doppler ultrasonography showed severe left ICA stenosis with the decreased flow. Computed tomography angiography demonstrated left ICA critical stenosis with compensatory flows from the right ICA. There was coexistent RAO with multiple emboli, silver-wiring, and segmentation of the retinal artery. More hyperreflective emboli were uncovered by infrared images of spectral-domain optical coherence tomography. Embolism may accompany with the compensatory flow for ICA occlusion. RAO patients should have thorough carotid evaluations, especially those with multiple retinal emboli.
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To study the clinical characteristics of macula off rhegmatogenous retinal detachment (RRD) with peripheral causative breaks and concomitant macular hole (RRD+MH). This is a bi-center study. Consecutive eyes of macula off RRD with or without macular hole (MH) were collected. Eyes in these two groups were compared with best corrected visual acuity in logarithm of minimal angle of resolution (logMAR BCVA), the presence of choroidal detachment (CD), proliferative vitreoretinopathy (PVR) and the extent of RRD. In the group of RRD+MH, regression analysis was used to evaluate the correlation of clinical factors and final logMar BCVA. In addition, optical coherence tomography was performed both pre-and post-operatively if possible. There were 40 eyes in the RRD+MH group and 80 eyes in the control group. Eyes with RRD+MH had worse initial and final logMar BCVA (p < 0.001), higher incidence of CD (p < 0.001), PVR and extensive RRD at baseline (p < 0.001). Among the eyes with RRD+MH, final BCVA was correlated with initial BCVA (p < 0.001, CI 0.637 to 0.837), recurrent RRD (p = 0.004, CI - 0.661 to - 0.126), duration of RRD (p = 0.021, CI - 0.576 to - 0.048) and presence of PVR (p = 0.001, CI - 0.131 to - 0.035). The hole closure rate at final follow up is 87.5%.11 of the 17 eyes had preoperative optical coherence tomography (OCT) obtained had ellipsoid zone lining the bottom of MH. CD, PVR and extensive RRD were more commonly observed in RRD+MH. The morphology of MH may suggest the pathogenesis of MH in RRD+MH include mechanism different from that of idiopathic MH.
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Descolamento Retiniano , Perfurações Retinianas , Tomografia de Coerência Óptica , Acuidade Visual , Humanos , Tomografia de Coerência Óptica/métodos , Perfurações Retinianas/diagnóstico por imagem , Perfurações Retinianas/patologia , Descolamento Retiniano/diagnóstico por imagem , Descolamento Retiniano/patologia , Feminino , Masculino , Pessoa de Meia-Idade , Idoso , Estudos RetrospectivosRESUMO
PURPOSE: The purpose of this study was to report the clinical characteristics and surgical outcome of familial exudative vitreoretinopathy-associated rhegmatogenous retinal detachment. METHODS: Retrospective interventional case series of patients with familial exudative vitreoretinopathy-associated rhegmatogenous retinal detachment. All cases had preoperative and postoperative clinical evaluations. Eyes were divided into three groups: no, moderate, and severe foveal dragging according to the status of fovea. Scleral buckling procedures or vitrectomy was performed to attach the retina. RESULTS: Twenty-four eyes in 22 patients were included in this study. The male to female ratio was 18:4. The average age was 16.42 ± 5.48 years. There were 14, 5, and 5 eyes in the no, moderate, and severe foveal dragging groups, respectively. Proliferative vitreoretinopathy was present in only one eye in the severe foveal dragging group. In the subgroup of eyes without foveal dragging, neither proliferative vitreoretinopathy, posterior located breaks, nor giant tears were noted. All eyes needed only scleral buckle to reattach the retina. In the subgroup with moderate foveal dragging, posterior located break was noted in one eye, which was the only eye in this group that needed vitrectomy besides scleral buckle to attach the retina. In eyes with severe foveal dragging, Stage D proliferative vitreoretinopathy was noted in one eye and posterior located break in one eye. Encircling buckle and vitrectomy were necessary in all eyes. The average number of operation is 1.1, 1.2, and 2.4 for each of the three groups, respectively. Final visual acuity improved in 23 of 24 eyes. Final retinal attachment was obtained in 95.8% of eyes (23 of 24). CONCLUSION: Male predominance and juvenile onset are the main characteristics in familial exudative vitreoretinopathy-associated rhegmatogenous retinal detachment. Surgical success rates are comparable to rhegmatogenous retinal detachment unassociated with familial exudative vitreoretinopathy in cases without severe foveal dragging and are worse in the group with severe foveal dragging.
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Osteoporose/cirurgia , Descolamento Retiniano/cirurgia , Recurvamento da Esclera , Vitrectomia , Vitreorretinopatia Proliferativa/cirurgia , Adolescente , Adulto , Criança , Vitreorretinopatias Exsudativas Familiares , Feminino , Humanos , Masculino , Osteoporose/fisiopatologia , Retina/fisiologia , Descolamento Retiniano/fisiopatologia , Estudos Retrospectivos , Resultado do Tratamento , Acuidade Visual/fisiologia , Vitreorretinopatia Proliferativa/fisiopatologia , Adulto JovemRESUMO
PURPOSE: The purpose of this study was to evaluate the effectiveness of pneumatic retinopexy as an alternative technique for repairing inferior rhegmatogenous retinal detachments. DESIGN: Retrospective, noncomparative, interventional case series. METHODS: A review on 13 patients (13 eyes) who had undergone pneumatic retinopexy as the initial procedure for primary retinal detachments with causative break(s) in the inferior one third of retina. After gas injection, all patients were instructed to maintain a lateral recumbent posture with head tilting 10 cm to 30 cm downward. RESULTS: Nine male and 4 female patients (mean age 28.1 years, ranging from 14 to 57) were included in this study. Eleven eyes (84.6%) had myopia of -3 diopters or higher. Macular detachment was found in eight eyes. Pneumatic retinopexy alone resulted in reattachment in 10 eyes (76.9%). Three other eyes needed additional scleral buckling. Final retinal reattachment was achieved in all 13 subjects. CONCLUSION: Inferior rhegmatogenous retinal detachment can be treated by pneumatic retinopexy with proper head position. More attention to the postoperative stage are required to ensure surgical success.
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Crioterapia , Fluorocarbonos/administração & dosagem , Decúbito Inclinado com Rebaixamento da Cabeça , Descolamento Retiniano/terapia , Adolescente , Adulto , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Reoperação , Descolamento Retiniano/fisiopatologia , Perfurações Retinianas/fisiopatologia , Perfurações Retinianas/terapia , Estudos Retrospectivos , Recurvamento da Esclera , Resultado do Tratamento , Acuidade Visual/fisiologia , Adulto JovemRESUMO
PURPOSE: To evaluate the structural features of central retinal artery occlusion by means of optical coherence tomography. METHODS: Eleven consecutive patients with acute central retinal artery occlusion and at least 3-month follow-up were enrolled prospectively in this study. The main outcome measures included best-corrected visual acuity, foveal thickness (FT), and total macular volume by optical coherence tomography. RESULTS: Five male and six female patients with central retinal artery occlusion were examined. The mean age was 71.2 ± 8.7 years (range, 59-83 years). Mean FT and total macular volume were 195 ± 26 µm and 6.41 ± 0.33 mm, respectively, in normal fellow eyes, increased to 299 ± 76 µm and 7.90 ± 0.93 mm, respectively, at initial examination and declined to 167 ± 30 µm and 4.85 ± 0.68 mm, respectively, at 3-month follow-up. Mean reduction in FT was 181 ± 61 µm (range, 120-270 µm) in eyes with poor visual outcome and 43 ± 25 µm (range, 15-74 µm) in eyes with fair visual outcome. Statistical analysis revealed that the relationships among visual prognosis and initial FT and initial total macular volume were not significant. CONCLUSION: Optical coherence tomography provides special information about central retinal artery occlusion. There were marked and variable changes in FT and total macular volume. Limited reduction in macular thickness might indicate a fair visual outcome.
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Macula Lutea/patologia , Oclusão da Artéria Retiniana/diagnóstico , Tomografia de Coerência Óptica , Doença Aguda , Idoso , Idoso de 80 Anos ou mais , Pesos e Medidas Corporais , Feminino , Angiofluoresceinografia , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Prospectivos , Oclusão da Artéria Retiniana/fisiopatologia , Acuidade Visual/fisiologiaRESUMO
PURPOSE: To investigate the effect of postoperative systemic steroid therapy on the incidence and duration of the subretinal fluid (SRF) and its correlation with the visual outcome after scleral buckle surgery for macula-off rhegmatogenous retinal detachment. METHODS: Prospective interventional study of sixty patients with macula-off rhegmatogenous retinal detachment who undertook scleral buckle surgery. Those patients who had recurrent retinal detachment, proliferative preretinal membrane, or primary surgical failure were excluded. Patients were assigned to Group 1 (with prescription of oral prednisolone for 3 days postoperatively) and Group 2 (with no such prescription).Furthermore, patients in Group 1 were subdivided into Group 1A (0.5 mg prednisolone/kg)and Group 1B (1 mg prednisolone/kg) according to the dosage of prednisolone. Patients were followed-up initially 1 week and 2 weeks after surgery and then on a monthly basis for at least 1 year. After the operation, all patients had corrected visual acuity and also received examinations of indirect ophthalmoscopy and optical coherence tomography. We compared the incidence, duration of SRF, and the correlation with the visual outcome between the groups. RESULTS: Lower incidence of SRF was noted in Group 1 than in Group 2 (56.7% vs. 80%;P = 0.052), and the duration of SRF was significantly shorter in Group 1 than in Group 2 (218 days vs. 286 days; P = 0.039). There was no significant difference in the final BCVA between the two groups. However, patients in Group 1 had greater improvements of BCVA 1 year after operation (13 lines vs. 7 lines in Groups 1 and 2, respectively; P = 0.026). Statistically,there were no difference between Groups 1A and 1B, in terms of the incidence of SRF,duration of SRF, final BCVA, and improvement of BCVA. CONCLUSION: Postoperative systemic steroid treatment may decrease the incidence of SRF and facilitate the absorption of SRF. Patients treated with steroids had greater improvement of BCVA.
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Glucocorticoides/administração & dosagem , Macula Lutea/patologia , Cuidados Pós-Operatórios , Prednisolona/administração & dosagem , Descolamento Retiniano/patologia , Descolamento Retiniano/cirurgia , Recurvamento da Esclera , Líquido Sub-Retiniano/efeitos dos fármacos , Absorção/efeitos dos fármacos , Administração Oral , Adolescente , Adulto , Idoso , Relação Dose-Resposta a Droga , Óculos , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Oftalmoscopia , Prevenção Primária/métodos , Estudos Prospectivos , Descolamento Retiniano/etiologia , Perfurações Retinianas/complicações , Perfurações Retinianas/cirurgia , Líquido Sub-Retiniano/metabolismo , Tomografia de Coerência Óptica , Resultado do Tratamento , Acuidade Visual , Adulto JovemRESUMO
PURPOSE: The purpose of this study was to determine if intravitreal bevacizumab can reduce subretinal exudates and exudative retinal detachment and facilitate the treatment of Coats disease in children. METHODS: Prospective, interventional, and noncomparative case series of three eyes in three children with Coats disease were studied. All eyes received only intravitreal bevacizumab injection as the primary treatment. Ablative procedures, including cryotherapy, traditional continuous wave laser, or subthreshold diode micropulse laser, for diseased vessels were performed after subretinal fluid totally reabsorbed. One supplementary intravitreal bevacizumab injection was given after ablative procedures on the same day. The changes in pre- and postoperative best-corrected visual acuity were recorded. Serial color fundus photography, optical coherence tomography, and B-scan sonography were performed to measure treatment efficacy. RESULTS: After receiving one to three injections, all three patients had subretinal fluid completely reabsorbed. All patients had one session of subsequent ablative procedures for diseased vessels and supplementary intravitreal bevacizumab injection. No patients had recurrent subretinal fluid. Improved visual acuity was noted in two cases but was not detectable in the other. No ocular or systemic complications related to bevacizumab were noted during the entire course of follow-up. CONCLUSION: Intravitreal bevacizumab appears to be a well-tolerated treatment for children with Coats disease. A favorable response is observed when compared with other treatment modalities. It has the potential as an adjuvant therapy of vascular ablative procedures to improve final vision and facilitate ongoing treatment.
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Inibidores da Angiogênese/uso terapêutico , Anticorpos Monoclonais/uso terapêutico , Doenças Retinianas/tratamento farmacológico , Telangiectasia/tratamento farmacológico , Anticorpos Monoclonais Humanizados , Bevacizumab , Criança , Vias de Administração de Medicamentos , Feminino , Angiofluoresceinografia , Humanos , Lactente , Masculino , Estudos Prospectivos , Doenças Retinianas/complicações , Vasos Retinianos/efeitos dos fármacos , Vasos Retinianos/patologia , Telangiectasia/complicações , Tomografia de Coerência ÓpticaRESUMO
PURPOSE: To introduce a case of bilateral retinal artery occlusions with carotid occlusions to achieve a fuller understanding of hemodynamic flow changes and the origin of emboli. OBSERVATIONS: A 58-year-old male presented with binocular vision loss. Fundus examination revealed bilateral retinal whitening with multiple emboli. Cherry red spot was surrounded and shaped by white edematous ischemic retina. FAG showed retinal refilling but not to the macula and choroidal background. Carotid arteriography and color Doppler images demonstrated bilateral carotid occlusions. CT angiography showed compensatory flows perfused from vertebral arteries for the brain. Orbital color Doppler images revealed bilateral reversed ophthalmic flows indicating another compensatory flow arising from external carotid/ophthalmic collaterals to both eyes. CONCLUSIONS AND IMPORTANCE: Reversed ophthalmic flow indicates the presence of external carotid/ophthalmic collaterals as the source of ocular blood supply and the origin of emboli. In this case, all the embolic, hemodynamic, and serotonin mechanisms may be responsible for the pathogenesis. RAO with multiple emboli is an important sign warning critical flow changes of carotid occlusions.
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OBJECTIVE: To introduce a special subgroup, retinal artery occlusion (RAO) with multiple emboli, which is highly associated with ipsilateral carotid artery occlusion disease (CAOD). METHODS AND ANALYSIS: This is a cohort study. Cases of RAO with multiple retinal emboli were consecutively enrolled. All patients underwent at least one of the carotid/cerebral evaluations: carotid arteriography, orbital/carotid colour Doppler ultrasonography and CT angiography to demonstrate haemodynamic changes and to discuss possible mechanisms and pathways of the emboli. RESULTS: Among 208 RAO eyes, 12 eyes (5.7%) in 11 patients had multiple emboli were recruited in this study. Eleven eyes (91.6%) had ipsilateral carotid plaques and atherosclerosis with high-grade stenosis; among them, five were total carotid occlusion. Haemodynamic changes were found in nine patients with RAO (81.8%) with carotid stenosis 60% or greater. Most compensatory intracranial circulations were re-established via the circle of Willi with antegrade ophthalmic flows, but the direction of ophthalmic flow reversed in three eyes indicating the recruitment of external collaterals. Two cases underwent carotid stent successfully. CONCLUSION: RAOs with multiple emboli are rare but highly associated with severe CAOD with haemodynamic flow changes, warning critical condition in carotid/cerebral circulations. Either direct embolism from the carotid or cardiac lesions or indirect embolism via the collateral pathways is the mechanism of pathogenesis. Immediate action should start to manage these patients to prevent further deterioration.
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PURPOSE: To report the visual and clinical outcomes of subthreshold diode micropulse (SDM) laser photocoagulation for chronic idiopathic central serous chorioretinopathy (ICSC) with juxtafoveal leakage. DESIGN: Prospective, noncomparative, interventional case series. PARTICIPANTS: Twenty-six eyes in 25 patients with persistent ICSC and juxtafoveal leakage longer than 4 months' duration. METHODS: All eyes were assigned to SDM photocoagulation. Eyes were divided into 3 groups based on the findings of fluorescein angiography. Groups 1 and 2 were those patients with source leakage without and with associated retinal pigment epithelial atrophy (RPE), respectively, whereas group 3 consisted of patients with diffuse RPE decompensation with indeterminate source leakage. All patients were followed-up for at least 6 months. MAIN OUTCOME MEASURES: The preoperative and postoperative best-corrected visual acuity, number of sessions of SDM photocoagulation, foveal thickness, and resolution of subretinal fluid (SRF) evaluated by ocular coherence tomography (OCT) were recorded. Patients also were tested for the presence or absence of laser-related scotoma with Amsler grid screening. RESULTS: Groups 1, 2, and 3 consisted of, respectively, 6, 9, and 11 eyes. In group 1, all patients had total SRF resorption after 1 session of SDM photocoagulation. Eight eyes in group 2 had total SRF resorption after 1 to 3 sessions of SMD laser, whereas 1 patient had persistent SRF. In group 3, only 5 eyes had SRF resorption at the end of the follow-up, and the other 6 eyes needed photodynamic therapy for final SRF resorption. At the end of follow-up, the average preoperative foveal thickness was reduced by more than half of its original thickness. A gain of visual acuity of 3 lines or more was achieved in 15 eyes (57.7%), and a gain of between 1 and 3 lines was achieved in 6 eyes (23.1%). CONCLUSIONS: Subthreshold diode laser is effective in the treatment of ICSC with point source leakage. However, for eyes with diffuse leakage, a less favorable response was noted. A multicenter, randomized clinical trial is needed to ascertain the real efficacy and the appropriate settings of SMD for chronic ICSC. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
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Fotocoagulação a Laser/métodos , Lasers Semicondutores , Doenças Retinianas/cirurgia , Vasos Retinianos/cirurgia , Adulto , Permeabilidade Capilar , Doença Crônica , Feminino , Angiofluoresceinografia , Seguimentos , Humanos , Masculino , Estudos Prospectivos , Doenças Retinianas/diagnóstico , Doenças Retinianas/fisiopatologia , Vasos Retinianos/metabolismo , Escotoma/diagnóstico , Soro , Resultado do Tratamento , Acuidade Visual/fisiologiaRESUMO
PURPOSE: To report a series of macular sparing rhegmatogenous retinal detachment (MSRRD) in teenagers treated with demarcation laser photocoagulation. METHODS: Retrospective, interventional, and noncomparative case series of 36 eyes in 33 patients with primary MSRRD. Eyes with ocular congenital anomalies or perforation ocular injury were excluded from this study. All eyes received three or more rows of confluent demarcation laser photocoagulation at the margin of retinal detachment. Best corrected preoperative and postoperative visual acuity and progression of retinal detachment during the follow-up were recorded. RESULTS: Thirty two eyes needed only one session of laser to wall off the retinal detachment. The other four eyes required one additional laser because of progressive retinal detachment. All but one eye had shallow retinal detachment and retinal detachment was successfully demarcated after 1 or 2 episodes of laser treatment at the final visit. Patients were observed up at our clinic from 1 to 6 years. Myopia greater than -3 D was noted in all but one eye. Atrophic holes with or without lattice were the causative breaks in all eyes. All patients maintained best corrected visual acuity equal or better than 20/30. CONCLUSION: Demarcation laser could successfully wall off macular sparing retinal detachment in teenagers.
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Fotocoagulação a Laser/métodos , Descolamento Retiniano/cirurgia , Adolescente , Feminino , Seguimentos , Humanos , Masculino , Descolamento Retiniano/fisiopatologia , Estudos Retrospectivos , Resultado do Tratamento , Acuidade Visual/fisiologia , Adulto JovemRESUMO
PURPOSE: To evaluate the effectiveness of pneumatic retinopexy as an alternative technique for rhegmatogenous retinal detachment (RD) repair in teenagers. DESIGN: Retrospective, noncomparative, interventional case series. METHODS: We conducted a review of 19 patients (19 eyes) younger than 20 years of age who had undergone pneumatic retinopexy as the initial procedure for rhegmatogenous RD between 1995 and 2002. RESULTS: Fourteen boys and five girls (mean age of 17.1 years) were included in this study. Two eyes had a history of trauma. Seventeen eyes (89.5%) had myopia of > -3 diopters. The averaged refraction of the operated eyes was -6.11 diopters (range, -1.25 to -9.5 diopters). Macular detachment was found in 13 eyes (68.4%). Subretinal fibrosis was present in six eyes (31.6%). Pneumatic retinopexy resulted in reattachment in 16 eyes (84.2%) with one injection of gas. One patient required a second injection of gas. Two patients needed additional scleral buckling to attach the retina. Displaced subretinal fluid and delayed resorption of subretinal fluid were noted in four eyes. Mean follow-up period was 42.7 months (range, six to 75 months). CONCLUSIONS: Rhegmatogenous RD in teenagers can be treated with pneumatic retinopexy with an overall successful rate as in adults. More attention is required regarding the postoperative stage and follow-up period to ensure surgical success.
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Crioterapia/métodos , Fluorocarbonos/administração & dosagem , Descolamento Retiniano/cirurgia , Adolescente , Adulto , Feminino , Fibrose , Seguimentos , Humanos , Fotocoagulação a Laser , Cristalino/fisiologia , Masculino , Miopia/complicações , Postura , Retina/patologia , Estudos Retrospectivos , Recurvamento da Esclera , Resultado do TratamentoRESUMO
This is an observational study of fluorescein angiography (FA) in consecutive patients with rhegmatogenous retinal detachment (RRD) in Changhua Christian Hospital to investigate the peripheral retinal vascular patterns in those patients. All patients had their age, sex, axial length (AXL), and refraction status (RF) recorded. According to the findings in FA of the peripheral retina, the eyes were divided into 4 groups: in group 1, there was a ramified pattern of peripheral retinal vasculature with gradual tapering; in group 2, there was an abrupt ending of peripheral vasculature with peripheral non-perfusion; in group 3, there was a curving route of peripheral vasculature forming vascular arcades or anastomosis; and in group 4, the same as in group 3, but with one or more wedge-shaped avascular notches. Comparisons of age, sex, AXL, and RF, association of breaks with lattice degeneration and retinal non-perfusion, surgical procedures utilized, and mean numbers of operations were made among the four groups. Of the 73 eyes studied, there were 13 eyes (17.8%) in group 1, 3 eyes (4.1%) in group 2, 40 eyes (54.8%) in group 3 and 17 eyes (23.3%) in group 4. Significant differences in age, AXL and RF, and association of retinal breaks to non-perfusion were noted among the four groups. Patients in group 1 had older ages, while younger ages were noted in groups 3 and 4. Eyes in group 1 had the shortest average AXL and were least myopic in contrast to the eyes in groups 3 and 4. Association of retinal breaks and retinal non-perfusion was significantly higher in groups 2, 3 and 4 than in group 1. In conclusion, peripheral vascular anomalies are common in cases with RRD. Patients with peripheral non-perfusion tend to be younger, with longer axial length and have the breaks associated with retinal non-perfusion.
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Oftalmopatias Hereditárias , Angiofluoresceinografia , Descolamento Retiniano , Vasos Retinianos , Adolescente , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Oftalmopatias Hereditárias/epidemiologia , Oftalmopatias Hereditárias/patologia , Oftalmopatias Hereditárias/fisiopatologia , Oftalmopatias Hereditárias/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Descolamento Retiniano/epidemiologia , Descolamento Retiniano/patologia , Descolamento Retiniano/fisiopatologia , Descolamento Retiniano/cirurgia , Vasos Retinianos/patologia , Vasos Retinianos/fisiopatologia , Taiwan/epidemiologiaRESUMO
We report 6 cases of indocyanine green (ICG)-related ocular toxicity after intravitreal ICG usage. Five cases had preoperative diagnosis of macular hole, 1 case had preoperative rhegmatogenous retinal detachment complicated with proliferative vitreoretinopathy. All cases received vitrectomy, ICG-assisted internal limiting membrane (ILM) peeling and air-fluid exchange. All eyes had residual ICG left at the end of surgery. Patients were followed up with indirect ophthalmoscopy, visual acuity, color fundus photography, fluorescein angiography, and ocular coherence tomography. Circular foveal retinal pigment epithelium atrophy larger than the area of macular hole and surrounding cuff was noted in 4 of 5 cases with preoperative macular hole. The other eye with preoperative diagnosis of macular hole had shallow anterior chamber and low intraocular pressure lasting for 1 week postoperatively. Diffuse retinal pigment epithelial atrophy was noted in the eye with preoperative proliferative vitreoretinopathy. Four eyes demonstrated optic atrophy postoperatively. Ocular toxicity caused by ICG may present as pigment epithelial atrophy, which is characteristically larger than the previous area of macular hole and surrounding cuff. Disc atrophy, retinal toxicity, and ocular hypotony were also observed in some cases. To prevent toxicity, residual ICG and ICG-stained ILM must be removed as completely as possible.
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Corantes/efeitos adversos , Verde de Indocianina/efeitos adversos , Retina/efeitos dos fármacos , Doenças Retinianas/induzido quimicamente , Idoso , Membrana Basal/patologia , Membrana Basal/cirurgia , Corpo Ciliar/efeitos dos fármacos , Corpo Ciliar/patologia , Feminino , Angiofluoresceinografia , Humanos , Masculino , Pessoa de Meia-Idade , Oftalmoscopia , Epitélio Pigmentado Ocular/efeitos dos fármacos , Epitélio Pigmentado Ocular/patologia , Retina/patologia , Descolamento Retiniano/cirurgia , Doenças Retinianas/diagnóstico , Perfurações Retinianas/cirurgia , Estudos Retrospectivos , Tomografia de Coerência Óptica , Acuidade Visual , Vitreorretinopatia Proliferativa/cirurgiaRESUMO
PURPOSE: To report a case of embolic cilioretinal artery occlusion caused by carotid artery dissection. DESIGN: Interventional case report. METHODS: A 38-year-old woman presented with acute visual loss in her right eye. Funduscopy showed a cilioretinal artery occlusion, which was confirmed by a fluorescein angiography. An embolus was found in the distal segment of the vessel. RESULTS: Color Doppler images of right internal carotid artery (ICA) disclosed a pseudolumen, suggesting a diagnosis of carotid dissection. Retrobulbar color Doppler image showed relative low flow velocity in the ophthalmic artery without flow reversal. Magnetic resonance angiography and cerebral angiogram showed total occlusion of the right ICA. Follow-up visual field examination revealed an inferior central defect fed by the cilioretinal artery. CONCLUSION: The pathogenesis of retinal artery occlusion caused by carotid dissection may be embolic or hemodynamic. In our case, a permanent visual defect was related to embolic occlusion of the cilioretinal artery.
Assuntos
Dissecação da Artéria Carótida Interna/complicações , Artérias Ciliares/patologia , Embolia/etiologia , Oclusão da Artéria Retiniana/etiologia , Adulto , Anticoagulantes/uso terapêutico , Velocidade do Fluxo Sanguíneo , Dissecação da Artéria Carótida Interna/diagnóstico , Dissecação da Artéria Carótida Interna/tratamento farmacológico , Angiografia Cerebral , Embolia/diagnóstico , Embolia/tratamento farmacológico , Feminino , Angiofluoresceinografia , Heparina/uso terapêutico , Humanos , Angiografia por Ressonância Magnética , Artéria Oftálmica/fisiopatologia , Oclusão da Artéria Retiniana/diagnóstico , Oclusão da Artéria Retiniana/tratamento farmacológico , Ultrassonografia Doppler em Cores , Campos VisuaisRESUMO
PURPOSE: To describe the findings of optical coherence tomography and clinical characteristics in patients of zonal outer retinopathy associated with punctuate inner choroidopathy. METHOD: Review of consecutive cases on fundus photographs, spectral domain ocular coherence tomography, fluorescein angiography, indocyanine green angiography, visual field, and electrophysiological studies of patients with punctate inner choroidopathy and associated zonal outer retinopathy. RESULTS: This study involves 4 patients suffering visual field defect far beyond the area corresponding to punctate inner choroidopathy lesions. Findings in optical coherence tomography include attenuated signals of photoreceptor inner/outer segment areas corresponding to visual field defect, and increased choroidal thickness. After treatment with immunosuppressive agents, improvements are noted in all 4 patients. CONCLUSION: Optical coherence tomography is helpful in the diagnosis of patients suffering zonal ocular outer retinopathy associated with punctate inner choroidopathy. All those patients responded well to immunosuppressive agents.
Assuntos
Corioidite/diagnóstico , Doenças Retinianas/diagnóstico , Tomografia de Coerência Óptica/métodos , Adulto , Corioide/patologia , Diagnóstico Diferencial , Eletrorretinografia , Feminino , Angiofluoresceinografia , Seguimentos , Fundo de Olho , Humanos , Coroidite Multifocal , Retina/patologia , Estudos Retrospectivos , Acuidade VisualRESUMO
PURPOSE: To describe the clinical characteristics of multilayered optic disc hemorrhages, which are defined as subretinal, superficial retinal, and subhyaloid or vitreous hemorrhages in adolescents. METHODS: Case records of adolescents with acute multilayered optic disc hemorrhages were identified and evaluated retrospectively from 1994 to 2012. The appearance of the hemorrhages including the size, location, extension, and disc anatomy was recorded. Fluorescein angiography, visual field examination, and spectral-domain optical coherence tomography were performed in select cases. RESULTS: Nine boys and 7 girls were included, with a mean age of 15.0 ± 2.6 years. No precipitating factor, such as involuntary Valsalva maneuver, was identified in the majority of patients (93.75%). All eyes were myopic with an average refraction of -4.64 ± 1.88 diopters. Fifteen (93.75%) of the affected optic discs were crowded and tilted with small cups. Peripapillary subretinal hemorrhages were all crescent in shape and located at the nasal disc. Eight (50%) eyes had marked subretinal blood extension exceeding 1 disc diameter away from the disc edge. Superficial flame hemorrhages were predominantly located in the superotemporal part of the disc. Spectral-domain optical coherence tomography of the disc showed vitreopapillary traction and obvious subretinal hemorrhage with increased thickness. All multilayered optic disc hemorrhages resolved spontaneously. CONCLUSIONS: Multilayered optic disc hemorrhages in adolescents more commonly affect myopic eyes with crowded and tilted discs. The visual outcome is excellent.
Assuntos
Disco Óptico/patologia , Doenças do Nervo Óptico/diagnóstico , Hemorragia Retiniana/diagnóstico , Hemorragia Vítrea/diagnóstico , Adolescente , Criança , Feminino , Angiofluoresceinografia , Humanos , Masculino , Miopia/diagnóstico , Miopia/fisiopatologia , Doenças do Nervo Óptico/fisiopatologia , Hemorragia Retiniana/fisiopatologia , Estudos Retrospectivos , Tomografia de Coerência Óptica , Acuidade Visual/fisiologia , Campos Visuais/fisiologia , Hemorragia Vítrea/fisiopatologia , Adulto JovemRESUMO
PURPOSE: To report a case of nonparaneoplastic autoimmune retinopathy presenting with severe peripheral retinal vasoocclusion. METHODS: Interventional case report. CASE REPORT: A 44-year-old woman complained of blurred vision and photopsia in both eyes. She has no history of cancer or autoimmune disease. Best-corrected visual acuity was 20/40 in the left eye and 20/30 in the right eye. Constriction of the visual field sparing central vision was found. Fluorescein angiography revealed severe peripheral retinal vasoocclusion, panretinal degeneration, and cystoid macular edema. Optical coherence tomography demonstrated intraretinal fluid. Electroretinography showed decreased amplitude of a- and b-waves in both scotopic and photopic tests. The implicit time was generally within normal limits. The amplitude of flicker response was also diminished. Multifocal electroretinography showed declined signal all over the macular region. Systemic workup including whole body positron emission tomography/computed tomography for cancer screening showed negative results. Only antirecoverin antibody was positive. Under the impression of nonparaneoplastic autoimmune retinopathy, systemic and local immunosuppressive therapy was given and showed improvement. CONCLUSION: Nonparaneoplastic autoimmune retinopathies are uncommon retinal degenerations with visual loss associated with unique clinical symptoms and findings and with serum antiretinal autoantibodies. Severe peripheral retinal vasoocclusion was not reported. Early detection and timely treatment with immunosuppression could result in clinical improvement.