Detalhe da pesquisa
1.
Design and discovery of C2-fluoroalkyl iminothiazine dioxides as BACE inhibitors.
Bioorg Med Chem Lett
; 56: 128463, 2022 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34838652
2.
fMRI study of olfactory processing in mice under three anesthesia protocols: Insight into the effect of ketamine on olfactory processing.
Neuroimage
; 213: 116725, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32173412
3.
Design and synthesis of water soluble ß-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors.
Bioorg Med Chem Lett
; 26(23): 5836-5841, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27836402
4.
MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.
J Pharmacol Exp Ther
; 355(3): 397-409, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26407721
5.
Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors.
Bioorg Med Chem Lett
; 23(3): 844-9, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23265892
6.
Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor.
Bioorg Med Chem Lett
; 22(7): 2444-9, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22390835
7.
Pharmacological BACE Inhibition Improves Axonal Regeneration in Nerve Injury and Disease Models.
Neurotherapeutics
; 17(3): 973-988, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32236823
8.
Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability.
Bioorg Med Chem Lett
; 19(21): 6032-7, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19800786
9.
Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 18(1): 215-9, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17988864
10.
Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators.
ACS Med Chem Lett
; 8(10): 1002-1006, 2017 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29057041
11.
Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AßPPswe Mice Without Inducing Microhemorrhage.
J Alzheimers Dis
; 59(4): 1393-1413, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28800329
12.
Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.
J Med Chem
; 60(7): 2983-2992, 2017 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28245354
13.
The BACE1 inhibitor verubecestat (MK-8931) reduces CNS ß-amyloid in animal models and in Alzheimer's disease patients.
Sci Transl Med
; 8(363): 363ra150, 2016 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27807285
14.
Structure-Based Design of an Iminoheterocyclic ß-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aß in Nonhuman Primates.
J Med Chem
; 59(7): 3231-48, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26937601
15.
Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A ß-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.
J Med Chem
; 59(23): 10435-10450, 2016 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27933948
16.
Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice.
Behav Brain Res
; 160(2): 344-55, 2005 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-15863231
17.
Spatial and nonspatial Morris maze learning: impaired behavioral flexibility in mice with ectopias located in the prefrontal cortex.
Behav Brain Res
; 133(2): 247-59, 2002 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-12110458
18.
Differential learning strategies in spatial and nonspatial versions of the Morris water maze in the C57BL/6J inbred mouse strain.
Behav Brain Res
; 133(2): 261-70, 2002 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-12110459
19.
Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer's disease.
Brain Res
; 945(1): 26-30, 2002 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-12113948
20.
Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein.
Brain Res
; 994(1): 99-106, 2003 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-14642453